A Comparative Analysis of CT Imaging Features in Xp11.2 Translocation/TFE Gene Fusion-Associated Renal Carcinoma versus Papillary Renal Cell Carcinoma
Main Article Content
Keywords
Renal cell carcinoma, Xp11.2 translocation/TFE gene fusion, Papillary renal cell carcinoma, Computed tomography, Imaging features, Multan.
Abstract
Renal cell carcinoma (RCC) presents with diverse morphological and genetic features, with Xp11.2 translocation/TFE gene fusion RCC and papillary RCC being two distinct subtypes. Understanding the computed tomography (CT) appearances of those subtypes is crucial for accurate diagnosis and treatment planning.
Aim: The current research aimed to compare the CT appearances of renal carcinoma associated with Xp11.2 translocation/TFE gene fusion and papillary renal cell carcinoma (PRCC).
Methods: A retrospective analysis was led at Chaudhry Pervaiz Elahi Institute of Cardiology, Multan, spanning six months and involving 100 patients diagnosed with renal carcinoma. CT images of patients with confirmed Xp11.2 translocation/TFE gene fusion RCC and PRCC were reviewed and compared. Various CT features including tumor size, enhancement pattern, necrosis, calcifications, and presence of lymphadenopathy were evaluated.
Results: The study identified distinct CT characteristics for Xp11.2 translocation/TFE gene fusion RCC and PRCC. Xp11.2 translocation/TFE gene fusion RCC commonly presented with larger tumor size, heterogeneous enhancement, and frequent necrosis. In contrast, PRCC exhibited smaller tumor size, peripheral enhancement, and less frequent necrosis. Additionally, calcifications were more frequently observed in PRCC cases. Lymphadenopathy was more commonly related with Xp11.2 translocation/TFE gene fusion RCC.
Conclusion: CT imaging plays a crucial role in differentiating between Xp11.2 translocation/TFE gene fusion RCC and PRCC. Recognition of distinct CT features can aid in exact diagnosis and guide appropriate management strategies for patients with renal carcinoma.
References
2. Wei S, Tian F, Xia Q, Huang P, Zhang Y, Xia Z, Wu M, Yang B. Contrast-enhanced ultrasound findings of adult renal cell carcinoma associated with Xp11. 2 translocation/TFE3 gene fusion: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. Cancer Imaging. 2020 Dec;20:1-0.
3. Huang W, Peng Y, Zhang Y, Qiu Y, Liu Y, Wang A, Kang L. Multimodality imaging of Xp11. 2 translocation/TFE3 gene fusion associated with renal cell carcinoma: a case report. Frontiers in Medicine. 2023 Sep 19;10:1266630.
4. Wu Y, Chen S, Zhang M, Liu K, Jing J, Pan K, Zhang L, Xu B, Lu X, Chen M. Factors Associated with Survival From Xp11. 2 Translocation Renal Cell Carcinoma Diagnosis—A Systematic Review and Pooled Analysis. Pathology and Oncology Research. 2021;27:610360.
5. Gan W, Dong X, Guo W, Zhou P, Pan J, Guo H. MED15-TFE3 Renal Cell Carcinoma: a Xp11 Translocation Renal Cell Carcinoma Subtype With Distinct Clinicopathological Features and Superior Prognosis.
6. Kmeid M, Akgul M. TFE3 Rearrangement and expression in renal cell carcinoma. International Journal of Surgical Pathology. 2023 Aug;31(5):509-20.
7. Yang H, Dong X, Pan X, Ma W, Pan J, Guo H, Gan W. A safe and effective treatment combination of neoadjuvant therapy and surgical resection for metastatic TFE3-rearranged renal cell carcinoma: a case report. Frontiers in Oncology. 2023;13.
8. van der Beek JN, Geller JI, de Krijger RR, Graf N, Pritchard-Jones K, Drost J, Verschuur AC, Murphy D, Ray S, Spreafico F, Dzhuma K. Characteristics and outcome of children with renal cell carcinoma: a narrative review. Cancers. 2020 Jul 3;12(7):1776.
9. Beek JN, Krijger RR, Nievelstein RA, Bex A, Klijn AJ, Heuvel-Eibrink MM, Littooij AS. MRI characteristics of pediatric and young-adult renal cell carcinoma: a single-center retrospective study and literature review. Cancers. 2023 Feb 22;15(5):1401.
10. Ayaz E, Ozcan HN, Oguz B, Haliloglu M. Beyond Wilms tumor: imaging findings and outcomes of rare renal tumors in children. Pediatric Radiology. 2022 Dec;52(13):2557-67.
11. Abdelmegeed SA, Farok HM, Refaat MM, Eldiasty TA. Role of multidetector ct in quantitative enhancement-washout analysis of solid renal masses. Egyptian Journal of Radiology and Nuclear Medicine. 2021 Dec;52:1-1.
12. Aganovic L, Nörenberg D. Benign and Malignant Renal Disease. InDiseases of the Abdomen and Pelvis 2023-2026: Diagnostic Imaging 2023 Mar 17 (pp. 153-168). Cham: Springer International Publishing.
13. van der Beek JN, Artunduaga M, Schenk JP, Eklund MJ, Smith EA, Lederman HM, Warwick AB, Littooij AS, Khanna G. Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration. Pediatric Blood & Cancer. 2023 May;70:e30080.
14. 谢尚桓, 徐志鹏, 陈聪, 綦黄鹏, 王建宁. Xp11. 2 易位/TFE3 基因融合相关性肾癌成人病例 1 例. Advances in Clinical Medicine. 2023 May 6;13:8014.
15. Aganovic L, Nörenberg D. Benign and Malignant Renal Disease. InDiseases of the Abdomen and Pelvis 2023-2026: Diagnostic Imaging 2023 Mar 17 (pp. 153-168). Cham: Springer International Publishing.
16. Zielli T, Gnetti L, Buti S. Activity of lenvatinib plus everolimus combination in a heavily pretreated patient with papillary renal cell carcinoma: a case report. Tumori Journal. 2020 Dec;106(6):NP79-83.
17. van der Beek JN, Artunduaga M, Schenk JP, Eklund MJ, Smith EA, Lederman HM, Warwick AB, Littooij AS, Khanna G. Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration. Pediatric Blood & Cancer. 2023 May;70:e30080.
18. van der Beek JN, Artunduaga M, Schenk JP, Eklund MJ, Smith EA, Lederman HM, Warwick AB, Littooij AS, Khanna G. Similarities and controversies in imaging of pediatric renal tumors: A SIOP‐RTSG and COG collaboration. Pediatric Blood & Cancer. 2023 May;70:e30080.
19. Herrscher H, Boilève A, Lindner V, Barthélémy P, Hutt É, Pierard L, Kurtz JE, Rioux-Leclercq N, Lang H, Malouf GG. Les carcinomes du rein à translocation de la famille MiT: histoire naturelle, caractéristiques moléculaire et prise en charge multidisciplinaire. Bulletin du Cancer. 2020 Feb 1;107(2):272-80.
20. Singh AC, Pal M, Kapoor A, Menon N, Prabhash K, Noronha V, Bakshi G, Prakash G, Menon S, Sable N, Kalra D. Study of Treatment Outcome in Adults with TFE-Related RCC. South Asian Journal of Cancer. 2021 Apr;10(02):92-6.
21. Sun H, Wei X, Zeng C. Autophagy in Xp11 translocation renal cell carcinoma: from bench to bedside. Molecular and Cellular Biochemistry. 2021 Dec;476(12):4231-44.
22. Yang H, Dong X, Pan X, Ma W, Pan J, Guo H, Gan W. A safe and effective treatment combination of neoadjuvant therapy and surgical resection for metastatic TFE3-rearranged renal cell carcinoma: a case report. Frontiers in Oncology. 2023;13.
23. Filler T, Verkarre V, Peyrottes A, Poinard F, Lupo A, Dariane C, Hurel S, Timsit MO, Mejean A, Audenet F. Clinical and pathological characteristics of renal cell carcinomas with MiTF translocation. The French Journal of Urology. 2024 Mar 1;34(2):102569.
24. van der Beek JN, Geller JI, de Krijger RR, Graf N, Pritchard-Jones K, Drost J, Verschuur AC, Murphy D, Ray S, Spreafico F, Dzhuma K. Characteristics and outcome of children with renal cell carcinoma: a narrative review. Cancers. 2020 Jul 3;12(7):1776.
25. Beek JN, Krijger RR, Nievelstein RA, Bex A, Klijn AJ, Heuvel-Eibrink MM, Littooij AS. MRI characteristics of pediatric and young-adult renal cell carcinoma: a single-center retrospective study and literature review. Cancers. 2023 Feb 22;15(5):1401.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.