COMPARATIVE ANALYSIS OF DEXMEDETOMIDINE AND PROPOFOL: HEMODYNAMIC AND SEDATIVE EFFECTS IN PROCEDURAL SEDATION
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Keywords
Procedural Sedation, Dexmedetomidine, Propofol, Hemodynamic Stability, Sedation Depth, Bispectral Index
Abstract
Abstract:
Background: Procedural sedation is essential for various medical procedures. This study compares the hemodynamic and sedative effects of dexmedetomidine and propofol during procedural sedation.
Materials and Methods: A randomized controlled trial was conducted on 100 participants undergoing elective procedures. They were divided into two groups receiving either dexmedetomidine or propofol. Hemodynamic parameters including heart rate, systolic and diastolic blood pressure, mean arterial pressure, and sedation depth measured by Bispectral Index (BIS) were recorded at baseline and at various time intervals. Statistical analysis was performed using t-tests with significance set at p < 0.05.
Results: Dexmedetomidine showed a significant reduction in heart rate (p < 0.001), systolic blood pressure (p = 0.075), diastolic blood pressure (p < 0.001), and mean arterial pressure (p < 0.001) compared to propofol. BIS scores were lower in the dexmedetomidine group throughout the study (p < 0.001).
Conclusion: Dexmedetomidine demonstrates superior hemodynamic stability and sedation depth compared to propofol during procedural sedation.
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S DHIVAKAR
Assistant surgeon, Manamadurai Government Hospital, Sivagangai , Tamilnadu, India
SRI HARI VIGNESH R
Assistant professor , Department of Anaesthesia , Palakkad institute of medical sciences, Walayar, Palakkad, Kerala, India
Dr Vivekanandhan.N
Assistant professor , Department of Anaesthesia , Palakkad institute of medical sciences, Walayar, Palakkad, Kerala, India
Dr S.Syed Mohammed Jazeel
Assistant surgeon, Koodankulam Government Hospital, Tirunelveli , Tamilnadu, India