BACTERIOLOGICAL PROFILE AND ITS ANTIMICROBIAL SUSCEPTIBILITY OF NEONATAL SEPSIS IN NEONATAL INTENSIVE CARE UNIT OF A TERTIARY HOSPITAL
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Keywords
Neonatal sepsis, Neonatal intensive care unit, Bacteriological profile, Antimicrobial susceptibility
Abstract
Abstract
Background: Neonatal sepsis, described as a systemic infection occurring inside the first month of life, remains a main cause of morbidity and mortality in neonatal intensive care units (NICUs) globally, posing extensive challenges to healthcare professionals and families.
Objective: This study aimed to investigate the bacteriological profile and antimicrobial susceptibility patterns of neonatal sepsis in the NICU of Combine Military Hospital (CMH), analyzing data from 105 patients.
Study Design: A retrospective study.
Duration and Place of a Study: This study was conducted at the Neonatal Intensive Care Unit (NICU) of Combine Military Hospital (CMH), Quetta, between February 2022 to February 2023.
Material and Methods: The study population comprised neonates admitted to the NICU for the study period who met the inclusion standards for suspected neonatal sepsis. Neonates with clinical symptoms suggestive of sepsis, including temperature instability, respiratory distress, feeding difficulties, lethargy, or abnormal laboratory parameters, were included in the study. Clinical and demographic data, which provides for gestational age, birth weight, mode of delivery, prenatal history, postnatal course, laboratory results, and antibiotic therapy, were retrieved from electronic clinical records and patient charts.
Results: The study included 105 neonates with suspected sepsis. The majority of the neonates were male (52.4%) and were born between 33-36 weeks of gestation (33.3%). The most common birth weight range turned into 1501-2500 grams (38.1%). Vaginal delivery was the most common mode of delivery (47.6%), followed by means of cesarean section (42.9%).
Conclusion: This study provides precious insights into the demographic and clinical characteristics of neonates with suspected sepsis.
References
2. Oumer M, Abebaw D, Tazebew A. Time to recovery of neonatal sepsis and determinant factors among neonates admitted in Public Hospitals of Central Gondar Zone, Northwest Ethiopia, 2021. PloS one. 2022 Jul 28;17(7):e0271997.
3. Flannery DD, Chiotos K, Gerber JS, Puopolo KM. Neonatal multidrug-resistant gram-negative infection: epidemiology, mechanisms of resistance, and management. Pediatric research. 2022 Jan;91(2):380-91.
4. Baltimore RS. Neonatal sepsis: epidemiology and management. Pediatric Drugs. 2003 Nov;5:723-40.
5. Russell AR. Neonatal sepsis. Paediatrics and Child Health. 2015 Jun 1;25(6):271-5.
6. Rallis D, Giapros V, Serbis A, Kosmeri C, Baltogianni M. Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis. Antibiotics. 2023 Mar 3;12(3):508.
7. Romandini A, Pani A, Schenardi PA, Pattarino GA, De Giacomo C, Scaglione F. Antibiotic resistance in pediatric infections: global emerging threats, predicting the near future. Antibiotics. 2021 Apr 6;10(4):393.
8. Winters C, Gelband H. Multidrug-Resistant Infections in Low-Resource Health Care Settings. Antibiotic Policies: Controlling Hospital Acquired Infection. 2012:141-62.
9. Oladokun RE, Alao MA, Ogunbosi BO, Bello OE, Ude I, Obasi A, Ayede AI, Tongo OO. Trends in Identification, Etiology, and Resistance Profiles of Bacterial Isolates and Appropriate Therapy for Neonatal Sepsis in Low-and Middle-Income Countries: a Narrative Review. Current Pediatrics Reports. 2023 Dec;11(4):214-21.
10. Sturrock S, Sadoo S, Nanyunja C, Le Doare K. Improving the Treatment of Neonatal Sepsis in Resource-Limited Settings: Gaps and Recommendations. Research and reports in tropical medicine. 2023 Dec 31:121-34.
11. Lim WH, Lien R, Huang YC, Chiang MC, Fu RH, Chu SM, Hsu JF, Yang PH. Prevalence and pathogen distribution of neonatal sepsis among very-low-birth-weight infants. Pediatrics & Neonatology. 2012 Aug 1;53(4):228-34.
12. Griffin MP, Lake DE, O'Shea TM, Moorman JR. Heart rate characteristics and clinical signs in neonatal sepsis. Pediatric research. 2007 Feb;61(2):222-7.
13. Tsai MH, Hsu JF, Chu SM, Lien R, Huang HR, Chiang MC, Fu RH, Lee CW, Huang YC. Incidence, clinical characteristics and risk factors for adverse outcome in neonates with late-onset sepsis. The Pediatric Infectious Disease Journal. 2014 Jan 1;33(1):e7-13.
14. Machado GP, Silva RC, Guimarães FF, Salina A, Langoni H. Detection of Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli in Brazilian mastitic milk goats by multiplex-PCR. Pesquisa Veterinária Brasileira. 2018;38:1358-64.
15. Hassuna NA, AbdelAziz RA, Zakaria A, Abdelhakeem M. Extensively-drug resistant Klebsiella pneumoniae recovered from neonatal sepsis cases from a major NICU in Egypt. Frontiers in microbiology. 2020 Jun 19;11:1375.
16. Mukherjee S, Mitra S, Dutta S, Basu S. Neonatal sepsis: the impact of carbapenem-resistant and hypervirulent Klebsiella pneumonia. Frontiers in Medicine. 2021 Jun 11;8:634349.
17. Kateete DP, Edolu M, Kigozi E, Kisukye J, Baluku H, Mwiine FN, Najjuka CF. Species, antibiotic susceptibility profiles and van gene frequencies among enterococci isolated from patients at Mulago National Referral Hospital in Kampala, Uganda. BMC infectious diseases. 2019 Dec;19(1):1-9.
18. Zavaryani SM, Mirnejad R, Piranfar V, Moghaddam MM, Sajjadi N, Saeedi S. Assessment of susceptibility to five common antibiotics and their resistance pattern in clinical Enterococcus isolates. Iranian journal of pathology. 2020;15(2):96.
19. Pol M, Ruegg PL. Relationship between antimicrobial drug usage and antimicrobial susceptibility of gram-positive mastitis pathogens. Journal of dairy science. 2007 Jan 1;90(1):262-73.
20. Vega S, Dowzicky MJ. Antimicrobial susceptibility among Gram-positive and Gram-negative organisms collected from the Latin American region between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial. Annals of clinical microbiology and antimicrobials. 2017 Dec;16:1-6.
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Arif Kibzai
Senior Register Pediatrics Department Sandeman Provincial Hospital, Quetta
Mehvish Mandokhail
PGR, FCPS, Pediatrics Department CMH, Quetta - Pakistan
Sanaullah Jamali
PGR Pediatrics Department, Sandeman Provincial Hospital, Quetta - Pakistan
Zulfiqar Mandokhail
Final Year MBBS Student in QIMS (Quetta Institute of Medical Sciences), - Pakistan
Sara Mandokhel
PGR, FCPS Neurology, Quetta - Pakistan
Ubaid Ullah
FCPS PGR Pediatrics Department, Bolan Medical College/ Hospital, Quetta - Pakistan
Mubina Aziz
Md House Officer, Qazi Hussain Ahmad Medical Complex, Nowshera - Pakistan