EFFICACY OF RACECADOTRIL IN CHILDREN (LESS THAN FIVE YEARS OF AGE) WITH ACUTE WATERY DIARRHEA AT TERTIARY CARE HOSPITAL
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Keywords
Acute diarrhea, Racecadotril, ORS and Zinc Sulphate
Abstract
Introduction: Acute diarrhea in children is a serious public health concern. In both industrialized and developing countries, it considerably raises morbidity in infants and early children despite advancements in oral rehydration therapy and recently introduced immunizations. Acidosis and dehydration due to excessive fluid and electrolyte losses are the main causes of acute watery diarrhea-related fatalities. In order to treat acute gastroenteritis in children, this study assessed the efficacy of oral rehydration solution alone versus racecadotril, an adjuvant to it and zinc Sulphate.
Objective: - The aim of this research was to assess the effectiveness of Racecadotril in treating acute diarrhea in children in a tertiary care hospital in comparison to oral rehydration solution alone.
Study design: Randomized controlled trial
Place and Duration: Pediatric Department of University Hospital, from 12 March 2021 to 12 September 2021
Methodology: A total of 252 children were assigned at random. Overall 126 patients in group B (the treatment group) received Racecadotril in addition to ORS and Zinc Sulphate, while 126 patients in group A (the placebo group) received only ORS and Zinc Sulphate. The frequency of stools during the first 72 hours following admission served as the main efficacy criterion. The length of time it took for diarrhoea to go away after starting Racecadotril was the main outcome indicator. Every piece of data was kept in a pre-made proforma.
Results: The children ranged in age from 23.31±14.05 months. Group B was found to be substantially more effective than Group A in treating acute diarrhoea in children (97.6% vs.
81.7%; p=0.0005).
Conclusion: In this trial, Racecadotril considerably outperformed the control group in terms of effectiveness in treating acute diarrhoea. In infants and children with acute diarrhoea, it demonstrated that Racecadotril is an efficient, well-tolerated supplement to oral rehydration therapy.
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Ayesha Almas
MBBS, FCPS, Woman medical officer, Department of pediatrics, Liaquat University Hospital Hyderabad. 03352447783
Kausar Keerio
MBBS, FCPS, senior registrar, pediatric department, Liaquat University of Medical and Health Sciences Jamshoro. 03313681574
Mameeta Kumari
MBBS (FCPS trainee), pediatric department, Liaquat University of Medical and Health Sciences Jamshoro. 03363073017
Fiza Syed Shah
MBBS, MPH (UK), FCPS, Woman medical officer, Department of pediatrics, Liaquat University Hospital Hyderabad. O3453532474
Muhammad Touseef
MBBS, FCPS, senior registrar, pediatric department, Liaquat University of Medical and Health Sciences Jamshoro. 03332614213
Faiza
MBBS, DCH, MD (Pediatrics), Woman Medical Officer, Department of Pediatrics, Sindh Government Hospital, Hyderabad. 03332684705