STUDY TO ASSESS THE EFFICACY AND TOLERABILITY OF HIGH PROTEIN ALBUMIN FORMULA (ALBUWISE) IN INDOOR PATIENTS WITH HYPOALBUMINEMIA: A RETROSPECTIVE ANALYSIS (INDI ALB-PHASE 2)
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Keywords
High Protein Albumin Formula (Albuwise), Hypoalbuminemia, Malnutrition, SGA score
Abstract
Background: Hypoalbuminemia is a common problem seen in hospitalized patients. Albumin is a major component of plasma protein and plays an important physiological role in the body. Serum albumin levels are frequently monitored in sick and malnourished individuals. Adequate protein supplementation in acutely sick patients can lower mortality and enhance quality of life. Protein supplementation formula derived from Egg and egg white protein could be an effective for supplementation in patients with hypoalbuminemia. Albuwise (High Protein, Albumin Formula), derived from egg. This study was conducted to assess the safety and efficacy of oral administration of this product in hospitalized patients with hypoalbuminemia.
Materials and Methods: This multicentric, retrospective, prescription event monitoring study included adult hospitalized patients with low serum albumin levels (<3.0 g/dl). Data was collected from data record files. The dosage of high protein Albumin Formula (Albu-wise) supplementation was determined by the dietitian and supplemented by oral route after conventional nutritional counseling. The dosages were divided or increased as per patient’s nutritional requirements and dietitian’s nutritional intervention. All the enrolled patients were monitored till 45 days for biochemical parameters, dietary intake and nutrition score from baseline and post intervention. Safety parameters were monitored as complaints of feeding intolerance, vomiting and stool consistency.
Results: Total study participants were 15(100%). At baseline mild- moderate malnourishment was in 60 %, food intolerance was absent in 66.7% and nausea & vomiting was present in 26.7%. Statistically significant and consistent improvement seen in all the component of components of serum protein, Calorie and protein intake. While supplementation dose of high protein Albumin Formula was reduced from 30 gm (10.00)/per day at baseline and 28 gm (10.82)/per days on 45th day. Subjective Global Assessment Scoring System was changed to grade A in 6 (40%) patients. Food intolerance was improved in 3 (20%), On the 45th day stool consistency was normal and nausea & vomiting was absent in all patients 15(100%).
Conclusion: High Protein Albumin Formula (Albuwise) is found to be safe and effective in improving serum albumin level among hospitalized patients with low serum albumin levels.
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Nidhi Singh
Clinical Nutritionist, Nucgnex Lifesciences, Pune, India
Anam Golandaz
Senior Clinical Dietician, Masina Hospital, Mumbai, India
Dr. Aritra Khan
Chief Dietitian Samaritan Medical Surgical & Critical Care, Kolkata