ASSOCIATION OF HYPERURICEMIA WITH PREECLAMPSIA IN SECOND TRIMESTER OF PREGNANCY

Main Article Content

Dr. Soniya Ilyas
Dr. Faiza Nawaz Khan
Dr. Amna Halima
Dr. Farhat Rehman
Dr. Zarka Sarwar
Dr. Atifullah Dawar

Keywords

Preeclampsia, serum uric acid, blood pressure, proteinuria, second trimester

Abstract

Background: Hypertension during pregnancy is a worldwide problem having serious consequences for the mother as well as the fetus. Uric acid is the end product of purine metabolism catalyzed by enzyme xanthine dehydrogenase/oxidase through several stimuli including ischemia. It is potent mediator of inflammation and through stimulation of inflammatory cytokines cause endothelial injury. Serum uric acid levels are proportional in women with pre-eclampsia.


Objective: To determine mean serum uric acid levels among pre-eclamptic women in the second trimester of pregnancy.


Material and methods:


Study Design: Descriptive cross-sectional


Setting: Pakistan Atomic Energy General Hospital Islamabad


Duration: 6 months from approval of synopsis i.e. 31-5-2018 to 1-12-2018


Data Collection Procedure: 100 indoor patients were included in the study. Data was collected using Performa which includes personal data of patients. 5ml of venous sample was taken from patients for quantification of serum uric acid level. Data was analyzed using version 21.0 of SPSS.


Results: The mean age of patients was 32.20±4.89years. The mean BMI of patients was 23.99±3.24kg/m2. The mean gestational age of patients was 22.11±1.46weeks. The mean blood pressure of patients was 150.40±7.34mmHg. The mean uric acid level was 7.25± 1.64mg/dl.


Conclusion: The average uric acid was high in females with preeclampsia and more than half of females had above-normal level of serum uric acid.

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