ASSOCIATION OF HYPERURICEMIA WITH PREECLAMPSIA IN SECOND TRIMESTER OF PREGNANCY
Main Article Content
Keywords
Preeclampsia, serum uric acid, blood pressure, proteinuria, second trimester
Abstract
Background: Hypertension during pregnancy is a worldwide problem having serious consequences for the mother as well as the fetus. Uric acid is the end product of purine metabolism catalyzed by enzyme xanthine dehydrogenase/oxidase through several stimuli including ischemia. It is potent mediator of inflammation and through stimulation of inflammatory cytokines cause endothelial injury. Serum uric acid levels are proportional in women with pre-eclampsia.
Objective: To determine mean serum uric acid levels among pre-eclamptic women in the second trimester of pregnancy.
Material and methods:
Study Design: Descriptive cross-sectional
Setting: Pakistan Atomic Energy General Hospital Islamabad
Duration: 6 months from approval of synopsis i.e. 31-5-2018 to 1-12-2018
Data Collection Procedure: 100 indoor patients were included in the study. Data was collected using Performa which includes personal data of patients. 5ml of venous sample was taken from patients for quantification of serum uric acid level. Data was analyzed using version 21.0 of SPSS.
Results: The mean age of patients was 32.20±4.89years. The mean BMI of patients was 23.99±3.24kg/m2. The mean gestational age of patients was 22.11±1.46weeks. The mean blood pressure of patients was 150.40±7.34mmHg. The mean uric acid level was 7.25± 1.64mg/dl.
Conclusion: The average uric acid was high in females with preeclampsia and more than half of females had above-normal level of serum uric acid.
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Dr. Soniya Ilyas
Senior Registrar Cantonment General Hospital, Rawalpindi – Pakistan
Dr. Faiza Nawaz Khan
Consultant Gynecologist, District Headquarters Hospital, Hunza - Pakistan
Dr. Amna Halima
Assistant Professor Anatomy, Bacha Khan Medical College, Mardan - Pakistan
Dr. Farhat Rehman
Associate Professor Physiology, Bacha Khan Medical College, Mardan - Pakistan
Dr. Zarka Sarwar
Assistant Professor Physiology Department, Bacha Khan Medical College, Mardan – Pakistan
Dr. Atifullah Dawar
Assistant Professor Physiology. Bacha Khan Medical College, Mardan – Pakistan