A STUDY OF FUNGAL SINUSITIS IN A TERTIARY CARE HOSPITAL IN MUMBAI
Main Article Content
Keywords
fungal sinusitis, Rhinosinusitis, fungal rhinosinusitis.
Abstract
Introduction: A fungal infection known as allergic sinusitis has a high risk of being infectious and aggressive. It is essential to understand and know the accurate prognosis of the disease in order to improve the quality of patient’s life. Fungal sinusitis has not been investigated in India yet due to a lack of research. A gap in the literature exists regarding clinical and histological representations of fungal infection, which encouraged us to conduct this present research.
Objective: To identify and isolate the etiological agent from clinically suspected cases of fungal sinusitis.
Material and methods: The biopsy samples from patients clinically suspected cases of fungal sinusitis over a period of one year were processed as per standard mycological procedures.
Results: Total 31samples suspected of fungal sinusitis were received. Out of them, 11 were positive. The isolated fungi include isolates of Rhizopus spp (5),Aspergillus flavus (2),Aspergillus spp (1),Syncephalostrum spp (1),Paecilomyces spp (1) each and a case of mixed infection by Aspergillus spp and Rhizopus spp. All patients had a common predisposing factor as diabetes mellitus. One of the cases proved to be fatal and the rest of all the patients were debrided surgically and started on antifungal agents Amphotericin B or itraconazole. On follow up, most of the cases were improving and some underwent plastic surgery.
Conclusion: Fungal sinusitis proves fatal unless treated effectively. Hence, it becomes necessary to include fungal sinusitis as differential diagnosis in patients presenting with paranasal sinus involvement.
References
2. Lanza DC, Dhong HJ, Tantilipikorn P, Tanabodee J, Nadel DM, et al. Fungus and chronic rhinosinusitis: From bench to clinical understanding. Ann OtolRhinolLaryngol2006; 196:27-34.
3. International Rhinosinusitis Advisory Board. Infectious rhinosinusitis in adults: classification, etiology and management. Ear Nose Throat J 1997;76:5-22
4. Schwartz S, Theil E. CNS- Aspergillosis: Are there new treatment options? Mycoses 2003; 46:8-14.
5. Joshi RR, Bhandary S, Khanal B, Singh RK. Fungal maxillary sinusitis: A perspective study in a tertiary care hospital in eastern Nepal. Kathmandu University Medical Journal 2007; 5:195-198.
6. de Shazo RD, Chapin K, Swain R. Fungal sinusitis. New Engl J Med 1997; 337:254 -259.
7. Gillespie MB, Bert WO, Harward WF. An approach to fulminant invasive fungal rhinosinusitis in the immunocompetent host. Arch Otolaryngol Head Neck Surg.1998; 124:520-526.
8. Larone DH. Medically Important Fungi‑ A guidance to Identification. 4thedition. Washington: American Society for Microbiology 2002; 293-348.
9. Chakrabarti A, Sharma SC. Paranasal sinus mycoses. Indian J Chest Dis Allied Sci 2000; 42:293‑304.
10. Das A, Bal A, Chakrabarti A, Panda NK, Joshi K. Spectrum of fungalrhinosinusitis; Histopathologist’s perspective. Histopathology 2009; 54:854‑859.
11. Prateek S, Banerjee G, Gupta P, Singh M, Goel MM, Verma V. Fungal rhinosinusitis: A prospective study in a University hospital of Uttar Pradesh. Indian J Med Microbiol 2013; 31:266-269.
12. Giri S, Kindo AJ, Rao S, Kumar AR. Unusual causes of fungal rhinosinusitis: A study from a tertiary care centre in South India. Indian J Med Microbiol. 2013; 31:379-384.
13. Michael RC, Michael JS, Ashbee RH, Mathews MS. Mycological profile of fungal sinusitis: An audit of specimens over a 7-year period in a tertiary care hospital in Tamil Nadu. Indian J Pathol Microbiol 2008; 51:493-496.
14. Tilak R, Kumar V, Nigam C, Gupta MK, Kumar R, Jain RK. Clinicomycological spectrum of fungal rhino-sinusitis from University Hospital, North India. J Clin. Diagnostic Research. 2012,6(4): 656-659
15. Kartikeyan P, Coumare VN. Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis. Indian J Otolaryngol Head Neck Surg. 2010; 62(4):381–385
16. V.P.Baradkar, M.Mathur, M.Panda, S.Kumar. Sino-orbital infection due to Syncephalastrum racemosum in chronic hepatorenal disease. – J Oral Maxillofacial Pathol 2008;12:45-47
17. R Gucalp, P Carlisle, P Gialanella, S Mitsudo, J McKitrick, J Dutcher. PaecilomycesSinusitis in an Immunocompromised Adult Patient: Case Rep Rev Clin Infect Dis 1996; 23:391-393.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Prachi Jawale
Junior resident department of Microbiology, Seth G.S.Medical college Mumbai
Dr. Vasant Purushottamrao Baradkar
Dept. of Microbiology, Seth G.S.Medical college Mumbai