SHORT COURSE VS PROLONGED RIFAXIMIN THERAPY FOR POST INFECTIOUS IRRITABLE BOWEL SYNDROME
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Keywords
celiac disease, ulcerative colitis
Abstract
BACKGROUND: The treatment of irritable bowel syndrome has evolved over the last so many years ranging from simple conservative measures to medications such as rifaximin.1
OBJECTIVE: To compare the effectiveness of short course vs prolonged rifaximin for post infectious irritable bowel syndrome.
MATERIAL AND METHODS: This study was conducted in MMC General Hospital Peshawar after the scrutiny and proper approval of the proposal from the ethical review of the committee of the hospital. The patients of IBS diagnosed according to the modified Rome criteria were in the inclusion criteria and patients having diarrhea die to other causes such as celiac disease, crohns diseases, ulcerative colitis was excluded from the study. A sample size of 50 was taken and method used was non-probability convenient sampling. The responses of the participants were recorded through a validated questionnaire comparing the symptoms with short course and long course of Rifaximin. The data was analyzed by SPSS version 22. Descriptive statistics were applied and the frequencies and percentages were applied were applied for categorical data whereas Mean and SD were applied for quantitative data. Results: The mean age of the patients was 32 years with males affected more as compared to females .The mean differences for stool frequency of stools was 0.4800 ,standard error of mean 0.164 ,confidence ranging from 0.811 to 0.148 and a very statistically significant value of 0.005 .Similarly for stool consistency and flatulence the mean differences 0.34 and 0.38 ,confidence interval ranging from 0.95 to 0.48 and 0.50 to 0.16 and highly statistically significant p values of 0.020 and 0.025 respectively.
CONCLUSION: So the long term rifaxmin therapy has better results for various symptoms of IBS.
References
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Henna Salman
Associate Professor Department of Physiology Khyber Medical College Peshawar.
Sajid Razaq
Department of Endocrinology, Hayatabad Medical Complex Peshawar.
Ayesha Qaisar
Assistant Professor Department of Physiology Khyber Medical College Peshawar.
Shafaq Naz
Professor of Medicine, Department of Medicine Kabir Medical College Peshawar.
Abdullah Khan
House officer Department of Medicine MMC General Hospital Peshawar.
Jibran Umar Ayub Khan
Associate Professor Gastroenterology, Department of Medicine Kabir Medical College Peshawar