LOW SYSTEMIC GANCICLOVIR EXPOSURE AND PREEMPTIVE TREATMENT FAILURE OF CYTOMEGALOVIRUS REACTIVATION IN A TRANSPLANTED CHILD

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Julie Autmizguine
Yves Théôret
Elise Launay
Michel Duval
Céline Rousseau
Bruce Tapiéro
Guy Boivin
Philippe Ovetchkine

Keywords

Cytomegalovirus, pediatric, pharmacokinetic, ganciclovir, resistance

Abstract

Prevention of cytomegalovirus (CMV) disease with ganciclovir has led to decrease morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. In the present report, we describe a case of ganciclovir treatment failure in a HSCT child who presented a refractory CMV infection despite harbouring a susceptible strain. The failure was partly attributed to sub-therapeutic plasma ganciclovir levels. Our experience emphasizes the importance of drug monitoring in immunocompromised patients.

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References

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