FORMULATION AND CHARACTERIZATION OF ETORICOXIB MICROCAPSULES VIA SOLVENT EVAPORATION FOR EMULGEL

Abstract

This research investigated the formulation and characterization of microcapsules containing a nonsteroidal anti-inflammatory drug (NSAID) through solvent evaporation methods. Microcapsules are widely used in various industries for encapsulating active ingredients, protecting sensitive materials, and controlling release kinetics. This study focused on the preparation and characterization of microcapsules using a solvent evaporation method. Different formulations were investigated, varying in the ratio of core material (NSAID) to shell material (polymers concentration). The influence of these parameters on the morphology, size distribution, and encapsulation efficiency of the microcapsules was systematically studied. Results indicated that formulations with higher polymer concentrations exhibited spherical shapes and higher entrapment efficiencies compared to those with lower concentrations. Optical microscopy was employed to analyze the size distribution of microcapsules, revealing sizes ranging from 50 to 500 µm. Furthermore, the impact of mixing speed during preparation emerged as a critical factor affecting microcapsule shape and size, with slower speeds resulting in potentially less spherical microcapsules. This comprehensive investigation provided valuable insights into the optimization of microcapsule preparation techniques for various applications in drug delivery, cosmetics, and food industries.