STRESS RESPONSES RELATED TO THE EFFECTS OF ANESTHETICS"

Gazi Matar S Aldhafeeri; Abdulrhman Saud Alrasheedi; Turki Matar Ali Alharbi; Jadaan Muhna Alshammari; Fahad Farhan Alharbi; Bandar Mubarak Almutairi; Nawaf Mofareh Alanazi; Mohammad Shetaiwi Alshammari; Abdulrahman Ghunaim Alanazi; Adel Khalid Alharbi; Nasser Khedhran Alghamdi

doi:10.53555/jptcp.v30i2.4704

Gazi Matar S Aldhafeeri
Abdulrhman Saud Alrasheedi
Turki Matar Ali Alharbi
Jadaan Muhna Alshammari
Fahad Farhan Alharbi
Bandar Mubarak Almutairi
Nawaf Mofareh Alanazi
Mohammad Shetaiwi Alshammari
Abdulrahman Ghunaim Alanazi
Adel Khalid Alharbi
Nasser Khedhran Alghamdi

Keywords

.

Abstract

This study investigates the differential impacts of Propofol, Sevoflurane, and Desflurane on stress responses in 150 elective surgery patients, emphasizing the importance of anesthetic choice in patient care. Utilizing a prospective observational design at a tertiary care center, we measured physiological stress markers (cortisol levels, heart rate, blood pressure) and psychological stress (via the State-Trait Anxiety Inventory) before and after anesthesia administration. Results highlighted Propofol's superior efficacy in significantly reducing both physiological and psychological stress markers compared to Sevoflurane and Desflurane. This suggests that Propofol not only ensures patient comfort during surgeries but also enhances postoperative recovery by mitigating stress responses. Our findings advocate for a strategic selection of anesthetics to optimize patient outcomes and satisfaction, positioning Propofol as a preferred choice for minimizing stress in surgical settings. This research underscores the nuanced role of anesthetics in stress modulation, contributing valuable insights into anesthetic practices aimed at improving surgical experiences and patient well-being.

Abstract 174 | pdf Downloads 22

References

1. Deiner, S., Silverstein, J.H., "Postoperative delirium and cognitive dysfunction," British Journal of Anaesthesia 103, suppl 1 (i41-i46). 2009.
2. Lepousé, C., Lautner, C.A., Liu, L., Gomis, P., Leon, A., "Emergence delirium in adults in the post-anaesthesia care unit," British Journal of Anaesthesia 96, no. 6 (747-753). 2006.
3. Stollings, J.L., Diedrich, D.A., Oyen, L.J., Brown, D.R., "Rapid-sequence intubation: A review of the process and considerations when choosing medications," Annals of Pharmacotherapy 50, no. 1 (62-76). 2016.
4. Apfelbaum, J.L., Chen, C., Mehta, S.S., Gan, T.J., "Postoperative pain experience: Results from a national survey suggest postoperative pain continues to be undermanaged," Anesthesia & Analgesia 97, no. 2 (534-540). 2013.
5. Vasileiou, I., Xanthos, T., Koudouna, E., et al., "Propofol: A review of its non-anaesthetic effects," European Journal of Pharmacology 605, nos. 1-3 (1-8). 2009.
6. Tan, T., Waxman, K., "Propofol: An update on its clinical use," Anesthesiology Research and Practice, 2012: 868179. 2012.
7. Moustafa, H.A.A., N.M. Aziz, M.M. Ragy, et al. "Ameliorative Effects of Ketamine Administration in Experimental Model of Chronic Unpredictable Mild Stress." Minia Journal of Medical Research. 2024.
8. Wei, X., Z. Liu, C. Liu, S. Li, J. An, and Z. Wang. "The Effect of Scalp Nerve Block on Postoperative Analgesia and Stress Response in Patients Undergoing Craniotomy: A Meta-Analysis." Alternative Therapies in Health and Medicine. 2024.
9. Yang, Y., J. Wu, S. Feng, H. Yu, C. Liu, and S. Wang. "Notoginsenoside R1 Attenuates Bupivacaine Induced Neurotoxicity by Activating Jak1/Stat3/Mcl1 Pathway." Toxicology. Elsevier. 2024.
10. Zhang, J., and J. Chen. "Stress Response and Safety of Lidocaine Combined with Dexmedetomidine in Patients Undergoing Laparoscopic Hysterectomy." Tropical Journal of Pharmaceutical Research. 2024.
11. Zheng, L., T. Fang, W. Zhang, X. Zhang, et al. "Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A …" Drug Design, Development and Therapy. Taylor & Francis. 2024.
12. Orak, Y., Fİ Tolun, M. Bakacak, and A. Yaylalı. 2021. "Effects of Propofol Versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients." Pain Research and Management. https://www.hindawi.com/journals/prm/2021/5517150/.
13. Erbas, M., Y. Demiraran, H.A. Yildirim, and G. Sezen. 2015. "Comparison of Effects on the Oxidant/Antioxidant System of Sevoflurane, Desflurane, and Propofol Infusion During General Anesthesia." Revista Brasileira de Anestesiologia. https://www.scielo.br/j/rba/a/6TFQyZ4bVZZNQ4yd8zsvRCm/?format=html&lang=en.
14. Yang, L., Z. Chen, and D. Xiang. 2022. "Anesthesia with Sevoflurane Combined with Propofol on Intraoperative Hemodynamics, Postoperative Stress Disorder, and Cognitive Function in Elderly Patients." Pakistan Journal of Medical Sciences. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9532675/.
15. Bhardwaj, A., H. Bhagat, V.K. Grover, N.B. Panda, and others. 2018. "Comparison of Propofol and Desflurane for Postanaesthetic Morbidity in Patients Undergoing Surgery for Aneurysmal SAH: A Randomized Clinical Trial." Journal of Anesthesia. https://link.springer.com/article/10.1007/s00540-018-2474-z.
16. Cusack, B., and D.J. Buggy. 2020. "Anaesthesia, Analgesia, and the Surgical Stress Response." BJA Education. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807970/.
17. Alhayyan, A., S. McSorley, C. Roxburgh, R. Kearns, and others. “The Effect of Anesthesia on the Postoperative Systemic Inflammatory Response in Patients Undergoing Surgery: A Systematic Review and Meta-Analysis.” Surgery Open Science (2020). https://www.sciencedirect.com/science/article/pii/S2589845019300156.
18. Ryu, KH., JA. Kim, DC. Ko, SH. Lee, WJ. Choi. “Desflurane Reduces Intraoperative Remifentanil Requirements More than Sevoflurane: Comparison Using Surgical Pleth Index-Guided Analgesia.” British Journal of Anaesthesia (2018). https://www.sciencedirect.com/science/article/pii/S000709121830494X.
19. Acar, D., EK. Erkılıç, T. Gümüş, D. Şahin, and others. “The Effects of Different Anaesthetic Techniques on Surgical Stress Response During Inguinal Hernia Operations.” Turkish Journal of Medical Sciences (2015). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917164/.
20. Perry, N.J.S., Buggy, D., & Ma, D. "Can anesthesia influence Cancer outcomes after surgery?" JAMA Surg (2019) 154(4): 279-280

pdf

Published

Feb 17, 2023

DOI https://doi.org/10.53555/jptcp.v30i2.4704

How to Cite

Gazi Matar S Aldhafeeri, Abdulrhman Saud Alrasheedi, Turki Matar Ali Alharbi, Jadaan Muhna Alshammari, Fahad Farhan Alharbi, Bandar Mubarak Almutairi, Nawaf Mofareh Alanazi, Mohammad Shetaiwi Alshammari, Abdulrahman Ghunaim Alanazi, Adel Khalid Alharbi, & Nasser Khedhran Alghamdi. (2023). STRESS RESPONSES RELATED TO THE EFFECTS OF ANESTHETICS". Journal of Population Therapeutics and Clinical Pharmacology, 30(2), 656–660. https://doi.org/10.53555/jptcp.v30i2.4704

Issue

Vol. 30 No. 2 (2023): JPTCP

Section

Articles

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.

Author Biographies