EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF PHYLLANTHUS ACIDUS IN WISTAR RATS
Main Article Content
Keywords
Hepatoprotective, Ethanol, Phyllanthus Acidus, Silymarin, In vivo.
Abstract
Objectives: The research set out to examine whether or not an ethanolic root extract of Phyllanthus Acidus (PA-E) might protect rats' livers against alcohol-induced damage.
Approach: Albino Wistar rats were given a 40 percent ethanol solution orally (2 milliliters per 100 grams of body weight) in order to cause hepatotoxicity. Oral doses of 100 mg/kg and 200 mg/kg of PA-E root extract were given for a duration of 21 days. Blood samples were taken from the retro orbital plexus on day 22 to assess the following biochemical parameters: total protein, albumin, triglycerides, total cholesterol, total bilirubin, creatinine, AST, ALP, urea, and total bilirubin. The animals were killed via cervical dislocation, and then their livers and kidneys were examined histopathologically.
The results showed that ethanol significantly raised liver weight, plasma ALT, AST, ALP, bilirubin creatinine, urea, triglycerides, and total cholesterol in comparison to the control group, but PA-E extract effectively prevented a significant decline in total protein and albumin concentration. Hepato protection was confirmed by histological findings, which corroborated the biochemical results.
Results suggest that PA-E root extract protects hepatocytes from ethanol-induced liver injury through its anti-oxidative effect. Phyllanthus acidus roots have strong hepatoprotective effects, according to the current study.
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Gorentala Shruthi
Research scholar, Department of Pharmaceutical Sciences, Monad University, Hapur, Uttar Pradesh
Ajith Kiran Karur
Assistant Professor, Department Of Pharmaceutical Sciences, Monad University, Hapur, Uttar Pradesh