SERUM LEVELS OF ADIPOCYTOKINES IN PEDIATRIC PATIENTS WITH FEBRILE SEIZURES AT SOHAG UNIVERSITY HOSPITAL.
Main Article Content
Keywords
Febrile seizure, Febrile convulsion, Adipokines, Adiponectin, Leptin
Abstract
Background: Febrile seizure (FS) is the most common cause of convulsion in Pediatric under the age of five, has not been fully evaluated regarding the pathogenesis.
Objective: This study aimed to evaluate serum levels of adipocytokines specifically, adiponectin and leptin in children with FS.
Patients and methods: A case-control study was conducted at the Departments of Pediatric department and Clinical Pathology unit of Sohag University Hospital,and 3 groups were included in this study with 30 children per group: Febrile seizures cases , healthy controls and febrile controls (FC) . Human enzyme-linked immunosorbent assay was used to measure the adiponectin and leptin serum levels during acute illness phase. Analysis of The independent factors associated with FS were done by A multivariate logistic regression tests.
Results: Both the FS and FC groups had comparable serum leptin level respectively (86 [56-99] vs. 78.5 [44-111], p 0.779) and adiponectin serum level respectively (median 43.5 [IQR 40-63] vs. 44 [39-83] μg/L, p 0.756), but both groups had significantly higher adiponectin (p 0.003, 0.004) and lower leptin (p 0.007, 0.004) levels in comparison to the HC group. The FS group had significantly higher body temperature on admission, creatinine, WBCs and CRP, but lower hemoglobin levels. However, in the multivariate logistic regression model, only higher body temperature on admission retained statistical significance (p 0.007).
Conclusion: There is no significant associations between Serum adiponectin and leptin levels with FS, but other comprehensive studies must be conducted on larger samples to confirm the results.
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Elsayed Abdelkreem
Departments of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt
Hager A. Mohamed
Departments of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt
Abdelrahim A. Sadek
Departments of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt
Abdelhady R. Abdel-Gawad
Departments Clinical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt
Amr A. Othman
Departments of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt