MYCOBACTERIUM TUBERCULOSIS AND DNA FINGERPRINTING: A VITAL TOOL FOR TRACKING OUTBREAKS
Main Article Content
Keywords
DNA Fingerprinting, Multi Drug Resistance, Genes, Strains
Abstract
Abstract: Genetic fingerprinting has been incorporated into epidemiological research to investigate TB micro-epidemics. TB control aims to pinpoint areas of transmission to halt the spread of the disease. accurate diagnosis of TB infection is essential to prevent disease progression. Traditional epidemiological studies, which relied on identifying plausible opportunities for transmission based on shared environments, have been greatly enhanced by the introduction of genetic techniques. The ability to characterize infecting organisms through DNA fingerprints has provided invaluable insights into the transmission dynamics of tuberculosis. By integrating these genetic data with traditional clinical, epidemiological, and public health information, we have gained a more comprehensive understanding of how tuberculosis spreads within populations. Moving forward, the continued use and refinement of tuberculosis DNA fingerprinting techniques will be crucial in identifying transmission links, guiding targeted interventions, and ultimately, reducing the burden of tuberculosis worldwide..This powerful tool holds the potential to revolutionize tuberculosis control strategies and bring us closer to achieving the goal of eliminating this disease as a global health threat
References
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16. Shafer RW, Singh SP, Larkin C, Small PM. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in an immunocompetent patient. Tuber Lung Dis. 1995;76(6):575-7. doi: 10.1016/0962-8479(95)90537-5, PMID 8593382.
17. Yeh RW, Hopewell PC, Daley CL. Simultaneous infection with two strains of Mycobacterium tuberculosis identified by restriction fragment length polymorphism analysis. Int J Tuberc Lung Dis. 1999;3(6):537-9. PMID 10383069.
18. Barnes PF, El-Hajj H, Preston-Martin S. Transmission of tuberculosis among urban homeless. JAMA. 1996;275:305-7.
19. Genewein A, Telenti A, Bernasconi C, Mordasini C, Weiss S, Maurer AM, et al. Molecular approach to identifying route of transmission of tuberculosis in the community. Lancet. 1993;342(8875):841-4. doi: 10.1016/0140-6736(93)92698-s, PMID 8104275.
20. Small PM, Hopewell PC, Singh SP, Paz A, Parsonnet J, Ruston DC, et al. The epidemiology of tuberculosis in San Francisco. A population-based study using conventional and molecular methods. N Engl J Med. 1994;330(24):1703-9. doi: 10.1056/NEJM199406163302402, PMID 7910661.
21. Alland D, Kalkut GE, Moss AR, McAdam RA, Hahn JA, Bosworth W, et al. Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods. N Engl J Med. 1994;330(24):1710-6. doi: 10.1056/NEJM199406163302403, PMID 7993412.
22. Chin DP, DeRiemer K, Small PM, de Leon AP, Steinhart R, Schecter GF, et al. Difference in contributing factors to tuberculosis incidence in U.S.-born and foreign-born persons. Am J Respir Crit Care Med. 1998;158(6):1797-803. doi: 10.1164/ajrccm.158.6.9804029, PMID 9847270.
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May 10, 2023
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Akanksha Verma, Shraddha Singh, Abhijeet Kashyap, Rakesh Saini, Ritik Dogra, Anirudh Sharma, Ankita Singh, Narotam Sharma, & Vijay Kumar. (2023). MYCOBACTERIUM TUBERCULOSIS AND DNA FINGERPRINTING: A VITAL TOOL FOR TRACKING OUTBREAKS. Journal of Population Therapeutics and Clinical Pharmacology, 30(11), 509–520. https://doi.org/10.53555/jptcp.v30i11.4539
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Author Biographies
Akanksha Verma
DNA Labs- A Centre for Applied Sciences, Dehardun, UK
Shraddha Singh
DNA Labs- A Centre for Applied Sciences, Dehardun, UK
Abhijeet Kashyap
Uttaranchal University, Dehradun, UK
Rakesh Saini
Uttaranchal University, Dehradun, UK
Ritik Dogra
Himachal Pradesh University, Summer Hills, Shimla, HP
Anirudh Sharma
Himachal Pradesh University, Summer Hills, Shimla, HP
Ankita Singh
DNA Labs- A Centre for Applied Sciences, Dehardun, UK
Narotam Sharma
Himachal Pradesh University, Summer Hills, Shimla, HP
Vijay Kumar
DNA Labs- A Centre for Applied Sciences, Dehardun, UK