EVALUATION OF DRUG-RELATED PROBLEMS (DRPS) IN THERAPEUTIC REGIMENS AT DIFFERENT MEDICINE WARDS OF LIAQUAT UNIVERSITY HOSPITAL JAMSHORO

Abstract

Introduction: Drug-related problems (DRPs) pose significant challenges in healthcare, often leading to ineffective medication use and adverse outcomes. This study aimed to assess the incidence and types of DRPs at a teaching hospital in Pakistan while evaluating the acceptance of pharmaceutical interventions by the medical team. Factors contributing to DRPs include polypharmacy, chronic diseases, and medication errors, with DRPs associated with increased morbidity, mortality, and healthcare costs.

Methodology: A cross-sectional study was conducted at Liaquat University Hospital, Jamshoro, Pakistan, between January and August 2023. Patients admitted for more than 24 hours were eligible, and DRPs were identified by trained clinical pharmacists using the PCNE V9.1 classification. Data sources included prescriptions, medical records, and lab tests. Pharmacist recommendations were documented, but due to limitations, interventions were not implemented.

Results: Out of 363 patients, 79.1% were found to have DRPs, with patient-related factors being the leading cause. Treatment effectiveness issues were the most common type of DRP, followed by safety concerns and other issues like unnecessary medication use. Causes of DRPs included inappropriate drug selection, dose selection, and dispensing errors. Medication reconciliation problems and lack of treatment outcome monitoring also contributed to DRPs.

Conclusion: Addressing systemic challenges is essential to enhance pharmacist roles in DRP management and ensure patient safety. Creating a supportive working environment for pharmacists is crucial for optimizing medication management and improving healthcare outcomes.