IN DEPTH ANALYSIS OF BRAIN STRUCTURE OF MULTIPLE SCLEROSIS PATIENT THROUGH MAGNETIC RESONANCE IMAGING
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Keywords
Multiple sclerosis, magnetic resonance imaging, brain structure, demyelinating lesions, clinical manifestations
Abstract
Introduction: Multiple sclerosis (MS) is a complex neurological disorder characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (CNS). Magnetic resonance imaging (MRI) has emerged as a valuable tool for assessing structural changes in the brains of MS patients. This study aims to provide a comprehensive analysis of brain structure in MS patients using qualitative analysis of MRI reports. By exploring the dynamic nature of demyelinating lesions and their correlation with clinical manifestations, this research contributes to a deeper understanding of MS pathophysiology and informs personalized treatment strategies.
Objective: This study aims to conduct an in-depth analysis of brain structure in multiple sclerosis (MS) patients using magnetic resonance imaging (MRI) techniques, exploring the dynamic nature of demyelinating lesions and their relationship with clinical manifestations.
Methods: Fourteen MS patients underwent MRI scans, and their reports were analyzed using qualitative methods. Thematic analysis was employed to identify common patterns and themes in structural brain changes. Demographic data were also collected and analyzed.
Results: MRI reports revealed characteristic T2 and FLAIR hyperintense signal abnormalities in periventricular and subcortical white matter regions in all patients. The absence of acute pathologies and the dynamic nature of demyelinating lesions were notable findings. Subtle non-specific signal abnormalities and chronic microvascular ischemic changes were also observed. Limitations include a small sample size and cross-sectional design, necessitating caution in generalizing the findings.
Conclusion: Despite limitations, this study provides valuable insights into structural brain alterations in MS patients, emphasizing the need for comprehensive diagnostic approaches and longitudinal studies. Future research should focus on larger cohorts, advanced imaging modalities, and clinical correlation to further elucidate MS pathophysiology and improve patient care strategies.
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Dr Rohail Azhar
Shifa College of Medicine Islamabad Pakistan
Dr Muneeb Hassan Khera
Shifa International Hospital Islamabad Pakistan
Muhammad Umer Yasir
Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Dr Hareem Khalid
Lahore medical and dental college, Lahore.
Dr Arham Yahya Rizwan Khan
Shifa College of Medicine Islamabad Pakistan
Dr ieman Zahid
CMH Medical College Lahore
Dr Rana Anees ur Rehman
Shifa International Hospital Islamabad Pakistan