Impact of Parenteral Amino Acid Intake on Electrolytes Levels Among Preterm Infants: A Retrospective Study

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Abdurahman Alatawi , Ibrahim Alatwi , Mashari M Alrayees , Fatimah A. Alharthi , Khaled R. A. Abdellatif


Parenteral amino acid, Preterm infants, Electrolytes level


Parenteral nutrition (PN) is recommended for premature babies weighing less than 1500 g. The administration of high doses of amino acids (AA) immediately after birth is recommended to maintain adequate premature growth and development. However, some studies have suggested that such high AA doses can cause electrolyte imbalance. Therefore, the aim of this study is to identify the correlation between daily AA intake and relative serum electrolyte levels. A retrospective cross-sectional study was conducted comparing two groups of preterm infants born before 34 weeks gestation with birth weights of less than 1500 g managed with PN. 214 infants’ records were included in the study: 121 were administered with less than 3 g/kg/day of AA (low-intake group) and 93 were administered at least 3 g/kg/day (high-intake group) throughout seven consecutive days. Serum sodium level was found to be normal in both groups; however, the mean value of patients received ≥ 3 g AA was higher than the patients receiving < 3g AA and this difference was statistically significant (p=0.011). The mean values of serum chloride, phosphate, potassium, magnesium, and calcium have no statistically significant difference between the two groups. Hyperchloremia and hypophosphatemia were observed in both groups. Hypermagnesemia and hypercalcemia were observed in patients receiving < 3 g AA. Thus, there was no association between electrolyte imbalance and the AA dose delivered by PN in the high-intake group of preterm infants.

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