Effect of intravenous dexmedetomidine on characteristics of spinal anaesthesia with hyperbaric bupivacaine: a prospective study.
Main Article Content
Keywords
Bupivacaine, Spinal Anaesthesia, Dexmedetomidine
Abstract
Context and Objectives: Dexmedetomidine cause sedation without respiratory depression, decrease stress response and cause prolongation of spinal anesthesia when given IV because of its actions on the substantia gelatinosa and locus coeruleus. So the present study was aimed to evaluate the effect of IV Dexmedetomidine on spinal anaesthesia with 0.5% of hyperbaric bupivacaine.
Material and Methods: Double-blind, randomized study involves 60 ASA-I/ASA-II patients’ undergone lower abdominal surgeries. Out of 60, 30 patients of Group-D were received IV Dexmedetomidine 0.5µg/kg diluted to 10ml with NS, infused over 10mins and 30 patients of Group-C received 10ml of NS infused over 10mins. Immediately after loading dose, spinal anaesthesia was performed in lateral position at L3–L4 space, using 25G Quincke spinal needle with 15mg of hyperbaric Bupivacaine. After SAB Group-D patients were received maintenance infusion of Dexmedetomidine at the rate of 0.5µg/kg/h IV and Group-C patients were received maintenance infusion of NS at the rate of 0.5µg/kg/h IV throughout surgery. Time of onset and duration of sensory and motor blockade, maximum level of sensory block achieved, duration of analgesia, heart rate and blood pressure profile were observed.
Statistical analysis used: Data was collected, tabulation formed and statistical analysis of continuous data was done by unpaired t-test and Chi-square test was applied for discrete data. Results were considered significant with p-value<0.05 and highly significant with p-value<0.001.
Results: IV Dexmedetomidine fastens the onset and duration of sensory block and motor blockade, also increases duration of analgesia. It decreases heart rate and blood pressure without respiratory depression throughout surgery.
Conclusions: IV Dexmedetomidine significantly improves characteristics of spinal anaesthesia with longer duration of analgesia and arousable sedation.
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Dr Purvi D. Thakkar
MBBS, MD (Senior resident, Department of Anaesthesiology) Department of Anaesthesiology, Narendra modi medical college, Ahmedabad
Dr Dhara R. Patel
MBBS, MD (Associate Professor, Department of Anaesthesiology) Department of Anaesthesiology, GMERS Medical college, Gandhinagar
Dr Ushma D. Shah
MBBS, DA, DNB (Assistant Professor, Department of Anaesthesiology) Department of Anaesthesiology, GMERS Medical college, Gandhinagar
Dr Shobhana Gupta
MBBS, MD (Professor and Head of Department of Anaesthesiology) Department of Anaesthesiology, GMERS Medical college, Gandhinagar
Dr Rajkumar Dudhani
MBBS (Second year resident, Department of Anaesthesiology) Department of Anaesthesiology, GMERS Medical college, Gandhinagar
Dr Barkha Mirchandani
MBBS (First year Resident, Department of Anaesthesiology) Department of Anaesthesiology, GMERS Medical college, Gandhinagar