DESIGN OPTIMIZATION AND EVALUATION OPHTHALMIC NANOEMULSION

Main Article Content

Madhavi Ruchake
Dr. Amol Tagalpallewar
Yashwant Nakhate
Pranali Kalambe

Keywords

Olapatadine, Opthalmic Nanoemulsion

Abstract

Nanoparticulate ophthalmic drug delivery systems  enhances the bioavailability of poorly water soluble drugs. It is an isotropic mixture of Oil, Surfactant, Cosurfactant (Smix), water and drug. Nanoemulsion, particularly, oil/water nanoemulsions have been investigated as a potential drug delivery system. Nanoemulsion possesses unique physicochemical properties namely, high solubilizing capacity for various drugs as well as acting as penetration enhancers to facilitate corneal drug delivery. Furthermore, the low surface tension of nanoemulsion would also guarantee a good spreading effect on the cornea and a proper mixing with the precorneal film constituents, thus would possibly improve the contact between the drug and corneal epithelium. Nanoemulsionhave good tissue permeability because of small size of micelles and the presence of surfactant among the components.

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