INFERTILITY AND OBESITY IN YOUNG ADULT WOMEN
Main Article Content
Keywords
anovulation, infertility, obesity
Abstract
Introduction: obesity has become a disease of concern worldwide, predominantly in women, due to the hormonal and environmental predisposition to which they are subjected during their childbearing age, therefore, being a multifactorial disease, it has an impact on the state of fertility in women, since it produces alterations in the menstrual cycle. These irregularities in the menstrual cycle secondary to the excess of adipose tissue also influence the development of other pathologies, so preventing obesity will allow us to counteract infertility in young adult women.
Methodology: A narrative literature review was carried out, the process of which includes informative material obtained from books and journals. Literature was excluded from reports, theses to obtain academic degrees or when access to them did not provide the full text, and review articles and clinical trials in English and Spanish, whose publication has been carried out in the last 5 years, obtained in databases: Scopus, Springer, Elsevier, Web of Science, PubMed, and Cochrane
Expected results: From the articles obtained on the subject, it was possible to know the epidemiological impact of obesity on infertility in young women, and the pathophysiological mechanisms determining infertility. Hence, women with abdominal obesity or higher body mass index have greater difficulty getting pregnant, both spontaneously and through assisted reproduction techniques.
Conclusion: obesity is a disease that causes several complications in women, due to its relationship with alterations in the menstrual cycle, ovarian and uterine failure, which result in problems in women's sexual function, mainly infertility. Therefore, taking preventive or corrective measures to control weight is advisable before trying to conceive spontaneously.
References
1. Andreu A, Casals G, Vinagre I, Flores L. Obesity management in women of reproductive age. Journal of Endocrinology, Diabetes and Nutrition [Internet]. April 27, 2023; 70(1):85–94. Available in: https://doi.org/10.1016/j.endinu.2022.04.007
2. Pereira J, Pereira Y, Quirós L. Infertility and factors that favor its appearance. Synergy Medical Journal. April 01, 2020; 5(5):485–95. Available in: https://doi.org/10.31434/rms.v5i5.485
3. Enríquez R. Obesity: an epidemic of the 21st century and its relation to fertility. Revista Médica Clínica Las Condes. 2021; 32(2):161–5. Available in: https://doi.org/10.1016/j.rmclc.2020.11.006
4. Quintero Y, Bastardo G, Angarita C, Rivas J, Suarez C, Uzcategui A. The study of obesity from different disciplines: Multiple approaches to the same vision. Venezuelan Journal of Endocrinology and Metabolism. 2020; 18(3):95–106. Available in: https://190.168.5.17/handle/123456789/47225/browse?type=dateissued
5. Vinueza A, Tapia E, Tapia G, Nicolalde T, Carpio T. Nutritional status of Ecuadorian adults and their distribution according to sociodemographic characteristics. Hospital Nutrition Magazine. 2023; 40(1):102–8. Available in: http://dx.doi.org/10.20960/nh.4083
6. Roman A, Pereira A, Garmendia M. Association between obesity with pattern and length of menstrual cycle: The role of metabolic and hormonal markers. Revista European Journal of Obstetrics and Gynecology and Reproductive Biology. 2021; 260:225–31. Available in: https://doi.org/10.1016/j.ejogrb.2021.02.021
7. Lim S, Harrison C, Callander E, Walker R, Teede H, Moran L. Addressing Obesity in Preconception, Pregnancy, and Postpartum: A Review of the Literature. Current Obesity Reports. November 01, 2022; 11(4):405–14. Available in: https://doi.org/10.1007/s13679-022-00485-x
8. Ramírez A, Ruiz L, Mora S, Saldarriaga S. Obesity in the female vital cycle, and its association with monthly disorders. Journal of Internal Medicine of Mexico. 2022; 38(2):344–54. Available in: https://doi.org/10.24245/mim.v38i2.3799
9. Lomba A, Camargo C, Villamil C, Díaz D, Guevara C, Hernández E, et al. Recommendations of the Colombian Association of Endocrinology, Diabetes and Metabolism for the management of obesity. 2023; 3:1–177. Available in: www.ebookmedico.com
10. Chaves B, Bermúdez D, Calderón M, Monge O. Metabolic syndrome and female fertility: clinical, endocrinological, and metabolic implications. Medical Journal of the University of Costa Rica. April 2021; 15(2): 15-33. Available in: https://orcid.org/0000-0002-5316-1196
11. Tan HS, Habib AS. Obesity in women: Anaesthetic implications for peri-operative and peripartum management. Anaesthesia. 2021; 76(4):108–17. Available in: 16 https://associationofanaesthetistspublications.onlinelibrary.wiley.com/doi/10.1111/an ae.15403
12. Quintana A, Rivas E, González J. Characterization of women with endocrine infertility. Finlay Magazine. 2019; 9(4):246–56. Available in: https://revfinlay.sld.cu/index.php/finlay/article/view/735
13. Lemamsha H, Randhawa G, Papadopoulos C. Prevalence of overweight and obesity among Libyan men and women. BioMed Research International. 2019; 19:1–16. Available in: https://doi.org/10.1155/2019/8531360
14. Sinchiguano B, Sinchiguano Y, Vera E, Peña S. Prevalence and risk factors of overweight and obesity in Ecuador. Scientific Journal of Research: Update of the World of Science. October 2022; 6(4):75–87. Available in: https://reciamuc.com/index.php/RECIAMUC/article/view/971
15. Balcázar M, Cañizares S, Caicedo A, León A, Zambrano K. Protocol for diagnosis and multidisciplinary management of overweight and obese adult patients in the outpatient clinic. Revista Bitácora Académica – USFQ. 2021; 9:1–67. Available in: https://revistas.usfq.edu.ec/index.php/bitacora/issue/download/182/134
16. Durrer D, Busetto L, Dicker D, Farpour N, Pryke R, Toplak H, et al. European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care. Obes Facts. 2019; 12(1):40–66. Available in: https://10.1159/000496183
17. Torres M, Ortiz Y, Pérez M, Torres M. Main causes of infertility in couples treated in municipal consultations. Eugenio Espejo Magazine. 2020; 15(1):30–42. Available in: https://eugenioespejo.unach.edu.ec/index.php/EE/article/view/140
18. Villanueva D, Conde D, Ojeda M, Ruiz N, Zambrano J. Anthropometric evaluation of body adiposity and cardiovascular risk in the adult population of Neiva, Colombia. Journal of Clinical Nutrition and Metabolism. 2023; 6(1):15–29. Available at: https://revistanutricionclinicametabolismo.org/index.php/nutricionclinicametabolismo /article/view/449
19. Vinueza A, Vallejo K, Revelo K, Yupa M, Riofrìo C. Prevalence of overweight and obesity in adults in the Ecuadorian highlands: Results of the ENSANUT-2018 survey. Rev Science at the Service of Health and Nutrition. 2021; 12(2):58–66.
20. Costa R, Gutiérrez A, Valdivieso D, Carpio L, Cuadrado F, Núñez J, et al. ESTEPS Ecuador Surveys: Surveillance of Noncommunicable Diseases and Risk Factors. Ministry of Public Health. Available in: https://www.salud.gob.ec/wp-content/uploads/2020/10/INFORME-STEPS.pdf
21. EQD Equity & Development Consultants. Country profile according to gender equality. 1 ed. Ecuador: United Nations System – Ecuador ;2022.
22. Imterat M, Agarwal A, Esteves SC, Meyer J, Harlev A. Impact of Body Mass Index on female fertility and ART outcomes. Panminerva Medica. 2019; 61(1): 58– 67. Available in: https://pubmed.ncbi.nlm.nih.gov/29962181/
23. Cena H, Chiovato L, Nappi R. Obesity, polycystic ovary syndrome and infertility: a new avenue for GLP-1 receptor agonists. Clin Endocrinol Metab Journal. 2020; 105(8): 2695-2709. Available in: 10.1210/clinem/dgaa285
24. Sanchez E. Update on the management of polycystic ovary syndrome. Synergy Medical Magazine. 2019; 4(12):322–32. Available in: https://doi.org/10.31434/rms.v4i12.322
25. Pasquali R, Oriolo C. Obesity and Androgens in Women. Front Horm Res. 2019; 53:120-34. Available in: https://pubmed.ncbi.nlm.nih.gov/31499497/
26. Snider AP, Wood JR. Obesity induces ovarian inflammation and reduces oocyte quality. Society for Reproduction and Fertility. 2019; 158(3):79–90. Available in: https://doi.org/10.1155/2019/8531360
27. Miguel Soca P, Feria G, González S, Leyva M. Obesity, inflammation and pregnancy, a dangerous triad. Cuban Journal of Obstetrics and Gynecology. 2020; 46(4): 1-17. Available in: https://revginecobstetricia.sld.cu/index.php/gin/article/view/605
28. Cozzolino M, García J, Meseguer M, Pellicer A, Bellver J. Female obesity increases the risk of miscarriage of euploid embryos. Fertil Steril. 2021; 115(6):1495– 502. Available in: https://doi.org/10.1016/j.fertnstert.2020.09.139
29. Martínez L, Pérez S. Obesity: Mechanisms, pathophysiology and comprehensive treatment. Science and Health Journal: Integrating Knowledge. 2022; 6(1):71–80. Available in: https://doi.org/10.34192/cienciaysalud.v6i1.395
30. Navarro M, Jáuregui I. Pharmacological treatment of obesity. Rev Endocrinology and Nutrition. 2020; 5(12):1464–9. Available in: https://www.elsevier.es/es-revista-endocrinologia-nutricion-12-articulotratamientofarmacologico-obesidad-9266
31. Rubio M, Fernández J, Corio R., Santos C, Urieta J. Pharmacological treatment of obesity for Primary Care physicians. They emerge. 2019; 45(8): 559–65. Available in: https://pubmed.ncbi.nlm.nih.gov/31350172/
32. Eisenberg D, Shikora S, Aarts E, Aminiam A, Angrisani L, Cohen R, et al. Indications for Bariatric and Metabolic Surgery. Spanish Society of Obesity Surgery. 2022: 3-7. Available in: https://www.seco.org/files/portalmenus/27/documentos/GUIDELINES-SECO.pdf
33. Kaufer M, Perez J. Obesity: pathophysiological and clinical aspects. INTER DISCIPLINA Magazine. 2021; 10(26): 147. Available in: https://doi.org/10.22201/ceiich.24485705e.2022.26.80973
34. Reyna N, Mejía J, Reyna E. Obesity, pregnancy complications, and long-term women's health. Revista Obstetricia Ginecología de Venezuela. 2021; 81(2): 162–9. Available in: https://doi.org/10.51288/00810210
35. Frigolet M, Dong K, Canizales S, Gutiérrez R. Obesity, adipose tissue, and bariatric surgery. Medical Bulletin of the Children's Hospital of Mexico. 2020; 77(1): 3–14. Available at: 10.24875/BMHIM.19000115