FORMULATION AND EVALUATION OF PHYTOSOMES OF PANAX GINSENG, NYMPHAEA STELLATA, MUCUNA PRURIENS, SYZYGIUM CUMINI AND AEGLE MARMELOS

Abstract

Since the turn of the century, numerous studies have been carried out to ensure the successful distribution of these plant-derived goods. Phytosomes possess a broad range of applications and attributes such as pharmacokinetics and pharmacodynamics. By considering the medicinal uses of Panax ginseng, Nymphaea stellata, Mucuna pruriens, Syzygium cumini and Aegle marmelos. This study deals with formulation, evaluation of polyherbal phytoosme to increase the phytoconstituents bioavailability. The preparation & characterization were performed by standard methods. Results showed that the Polyherbal phytosomes size and entrapment efficiency 215.65nm and 74.45%.  The polyherbal phytosomal formulation was observed to have λ_max of 276nm. Further the In vitro drug release study data suggested that in 12 hours 97.85% and 98.78% drug release occur in PGF2 and NSF 3.  In case of MPF3, SCF3, and AMF3 about  97.65 %, 98.12% 97.14% drug release occurred in 12 hours. In case of polyherbal phytosome about 96.65% drug is released. Acoording to Regression analysis data the R² value for PGF2 was found to be highest for Higuchi which is 0.995.  NSF3 was also found to follow Higuchi model with R² value of 0.990.  In case of MPF3, SCF3, AMF3 the R² value was estimated to be 0.987, 0.975, 0.983 which is highest and found to follow Korsmeyer Peppas model.  For polyherbal phytosomal gel Higuchi was observed to be followed with R² value of 0.979.  Thus, it can be concluded that it is crucial to remember that a number of variables, such as dietary lipid consumption, can have a substantial impact on the pace, degree, and total bioavailability of medications via these systems