FORMULATION AND EVALUATION OF PHYTOSOMES OF PANAX GINSENG, NYMPHAEA STELLATA, MUCUNA PRURIENS, SYZYGIUM CUMINI AND AEGLE MARMELOS

Main Article Content

Suresh Singh
Dr. Namrata Singh

Keywords

Phytososme, Panax ginseng, Nymphaea stellata, Mucuna pruriens, Syzygium cumini and Aegle marmelos, polyherbal

Abstract

Since the turn of the century, numerous studies have been carried out to ensure the successful distribution of these plant-derived goods. Phytosomes possess a broad range of applications and attributes such as pharmacokinetics and pharmacodynamics. By considering the medicinal uses of Panax ginseng, Nymphaea stellata, Mucuna pruriens, Syzygium cumini and Aegle marmelos. This study deals with formulation, evaluation of polyherbal phytoosme to increase the phytoconstituents bioavailability. The preparation & characterization were performed by standard methods. Results showed that the Polyherbal phytosomes size and entrapment efficiency 215.65nm and 74.45%.  The polyherbal phytosomal formulation was observed to have λmax of 276nm. Further the In vitro drug release study data suggested that in 12 hours 97.85% and 98.78% drug release occur in PGF2 and NSF 3.  In case of MPF3, SCF3, and AMF3 about  97.65 %, 98.12% 97.14% drug release occurred in 12 hours. In case of polyherbal phytosome about 96.65% drug is released. Acoording to Regression analysis data the R² value for PGF2 was found to be highest for Higuchi which is 0.995.  NSF3 was also found to follow Higuchi model with R² value of 0.990.  In case of MPF3, SCF3, AMF3 the R² value was estimated to be 0.987, 0.975, 0.983 which is highest and found to follow Korsmeyer Peppas model.  For polyherbal phytosomal gel Higuchi was observed to be followed with R² value of 0.979.  Thus, it can be concluded that it is crucial to remember that a number of variables, such as dietary lipid consumption, can have a substantial impact on the pace, degree, and total bioavailability of medications via these systems

Abstract 39 | pdf Downloads 27

References

1. Poddar S, Sarkar T, Choudhury S, Chatterjee S, Ghosh P. Indian traditional medicinal plants: A concise review. International Journal of Botany Studies. 2020;5(5):174-90.
2. Rungsung W, Dutta S, Das D, Hazra J. A brief review on the botanical aspects and therapeutic potentials of important Indian medicinal plants. International Journal of Herbal Medicine. 2013;1(3):38-45.
3. Devi VK, Jain N, Valli KS. Importance of novel drug delivery systems in herbal medicines. Pharmacognosy reviews. 2010 Jan;4(7):27.
4. Date AA, Naik B, Nagarsenker MS. Novel drug delivery systems: potential in improving topical delivery of antiacne agents. Skin pharmacology and physiology. 2005 Dec 7;19(1):2-16.
5. Tripathy S, Patel DK, Barob L, Naira SK. A review on phytosomes, their characterization, advancement & potential for transdermal application. Journal of Drug Delivery and Therapeutics. 2013 May 13;3(3):147-52.
6. Awasthi R, Kulkarni GT, Pawar VK. Phytosomes: an approach to increase the bioavailability of plant extracts. Int J Pharm Pharm Sci. 2011;3(2):1-3.
7. Kumar A, Kumar B, Singh SK, Kaur B, Singh S. A review on phytosomes: novel approach for herbal phytochemicals. Asian J Pharm Clin Res. 2017;10(10):41-7.
8. Kiefer D, Pantuso T. Panax ginseng. American family physician. 2003 Oct 15;68(8):1539-42.
9. Coleman CI, Hebert JH, Reddy P. The effects of Panax ginseng on quality of life. Journal of clinical pharmacy and therapeutics. 2003 Feb;28(1):5-15.
10. Das DR, Sachan AK, Mohd S, Gangwar SS. Nymphaea stellata: a potential herb and its medicinal importance. Journal of Drug Delivery and Therapeutics. 2012 May 14;2(3).4
11. Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The magic velvet bean of Mucuna pruriens. Journal of traditional and complementary medicine. 2012 Oct 1;2(4):331-9.
12. Srivastava S, Chandra D. Pharmacological potentials of Syzygium cumini: a review. Journal of the Science of Food and Agriculture. 2013 Jul;93(9):2084-93.
13. Sabu MC, Kuttan R. Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian Journal of physiology and pharmacology. 2004 Jan 1;48(1):81-8.
14. Gnananath K, Nataraj KS, Rao BG. Phospholipid complex technique for superior bioavailability of phytoconstituents. Advanced pharmaceutical bulletin. 2017 Apr;7(1):35.
15. Deleanu M, Toma L, Sanda GM, Barbălată T, Niculescu LŞ, Sima AV, Deleanu C, Săcărescu L, Suciu A, Alexandru G, Crişan I. Formulation of Phytosomes with Extracts of Ginger Rhizomes and Rosehips with Improved Bioavailability, Antioxidant and Anti-Inflammatory Effects In Vivo. Pharmaceutics. 2023 Mar 25;15(4):1066.
16. Clogston JD, Patri AK. Characterization of nanoparticles intended for drug delivery. Methods in Molecular Biology. 2011;697.
17. Froiio F, Gagliardi A, Fresta M, Cosco D, Paolino D. Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application. Novel Drug Delivery Systems for Phytoconstituents; Gupta, M., Chauhan, DN, Vikas, S., Nagendra, SC, Eds. 2019 Jul 23:105-19.
18. Kalita B, Das MK, Sharma AK. Novel phytosome formulations in making herbal extracts more effective. Research Journal of pharmacy and technology. 2013;6(11):1295-301