COMPARATIVE STUDY ON WOUND HEALING WITH BETADINE, SILVER SULPHADIAZINE, SOFRAMYCIN AND PHENYTOIN AS DRESSING AGENTS IN DIABETIC FOOT ULCERS
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Abstract
Background: Diabetic foot ulcer is a major global concern accounting for huge chunk of global healthcare attention and patient suffering. Dressing agents like betadine, silver sulphadiazine, soframycin and phenytoin show promising results with reducing duration of diabetic foot ulcers and its complications. The intention of this particular study is to compare efficacy of each of the four mentioned dressings and compare their rate of granulation and epithelization in diabetic foot ulcers.
Methods: Diabetic patients presented with foot ulcers were divided into 4 groups of 50 in each group.In Group 1 , Betadine is used as Dressing agent. In Group 2, Silver sulphadiazine is used as dressing agent.In Group 3 , Soframycin is used as dressing agent. In Group 4 ,Phenytoin is used as dressing agent.
Study design – A Prospective interventional study in a Tertiary care hospital
Duration of the study – 12 months from institutional scientific committee and institutional ethical committee approval
The wound surface areas are measured using Graph paper – Tracing method. The wound surface areas were measured initially at the beginning of the study and one again at the 21st day.
Results: The reduction in ulcer surface area is expressed as percentage points in comparision to ulcer surface area at the start of the study to the ulcer surface area at the end of 21 days . Group 1 (Betadine) showed a reduction in ulcer surface area at 57.59±14.456% , Group 2 (silver sulphadiazine) showed a reduction in ulcer surface area at 56.74 ± 12.710 % , Group 3 (Soframycin) showed a reduction in ulcer surface area at 54.16 ± 15.512% with and Group 4(Phenytoin) showed a reduction of ulcer surface area at 61.46 ± 8.938%
Conclusion: The diabetic foot ulcers in Topical phenytoin dressing group contracted more than those in patients with Betadine, Silver sulphadiazine and Soframycin groups (61.46% as compared to 57.59%, 56.74% and 54.16% with statistical significance), which indicates that the Topical Phenytoin dressing therapy is one of the effective modality to aid the reduction of wound surface area in patients suffering from diabetic ulcer.
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Dr. Bodagala Venkata Radha Krishna Teja
Resident in Department of Urology, Gandhi medical college, Secunderabad .Mobile No.7093393070
Dr. Budamala Sarada
Associate Professor, Department of General Surgery, S.V.Medical college, Tirupati. Mobile No. 9989781075
Dr. M Pradeep
Assistant Professor of General Surgery, SVRRGGH, Tirupati. Mobile No. 9440443791
Dr. Padala Adithya
Post graduate, Department of General Surgery, S.V.Medical college, Tirupati. Mobile No. 9550666923
Dr. Aluvala Vamshi Krishna
Post graduate, Department of General Surgery, S.V Medical College, Tirupati. Mobile No.7386682645
Dr. Bukke Ramanjineyulu Naik
Post Graduate, Department of General Surgery, S.V.Medical college, Tirupati. Mobile No. 8790787548