ANTICONVULSANT ACTIVITY OF WOODFORDIA FRUTICOSA (L.) KURZ FLOWERS IN ANIMAL SCREENING MODELS
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Keywords
Epilepsy, Woodfordia fruticosa (L.) Kurz flowers extract, MES, PTZ model
Abstract
The purpose of this study was to investigate the anti-seizure activities of an ethanolic extract obtained from Woodfordia fruticosa (L.) Kurz flowers in mouse models with convulsions. The ethanolic extract of Woodfordia fruticosa (L.) Kurz flowers (EWF) was made in a continuous manner using a Soxhlet device. EWF was given orally to albino mice at doses of 100 and 200 mg/kg body weight, coupled with phenytoin. The anti-epileptic activity was evaluated using maximum electroshock (MES) and pentylenetetrazol (PTZ)-induced seizure models. In comparison to the control group, protection against convulsions was determined by eliminating the tonic hind limb extension phase and increasing seizure latency period. EWF, at doses of 100 and 200 mg/kg body weight, had considerable anti-epileptic activity in both MES and PTZ-induced seizure models. Notably, the MES model eliminated the tonic hind limb extension phase, whereas the PTZ-induced seizure model increased the seizure latency period significantly. The results indicate that the ethanolic extract obtained from Woodfordia fruticosa (L.) Kurz flowers has significant anti-epileptic effect. Further research is required to discover its active ingredients and determine its antiepileptic mode of action.
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Parameshwari K
Associate Professor St Peter's Medical college Hospital and Research Institute Hosur- 635109, Tamilnadu, India.
Nandini T
Professor and Head, Department of Pharmacology, Sri Siddhartha Medical College Tumkur-572105Karnataka,India
Naveen Chandra
Department of Obstetrics and Gynaecology, Chamarajanagar Institute of Medical Sciences, Chamarajanagar-571313, Karnataka, India
Sangeetha R Gore
Assistant Professor, Department of Pharmacology, Chamarajanagar Institute of Medical Sciences Chamarajanagar- 571313, Karnataka, India.