PRECURSOR LESIONS AND ORAL CANCER TUMORIGENESIS: A PATHOGENETIC MODEL OF SURVIVIN-DEPENDENT MOLECULAR SIGNALLING PATHWAYS

Main Article Content

Nimra Noreen
Zoya Quddus
Muhammad Masood Ahmad
Haroon Amin
Muhammad Hassan Sadiq

Keywords

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Abstract

Introduction: The p53 tumor suppressor gene regulates cellular growth in response to DNA damage by inducing G1 arrest and apoptosis. Survivin, an apoptosis inhibitor, inhibits caspases and modulates the cell cycle, primarily found in minimal amounts in mature tissues. The aberrant expression of p53 and survivin has been explored in various carcinomas.


Objectives: The basic aim of the study is to investigate the co-expression of p53 and survivin in tissue samples from Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCCs).


Methodology: The study utilized 50 tissue samples each from OPMDs and OSCCs obtained from department archives. Immunohistochemistry was employed to assess the expression of p53 and survivin in the study groups, alongside the evaluation of their co-expression.


Results: The oral epithelium of patients with OSCCs exhibited significantly higher expression levels of p53 and survivin compared to patients with OPMDs (P value ≤0.05).


Conclusion: It is concluded that altered co-expression of survivin and p53, indicating significant immune expression. These markers could serve as valuable indicators for cell proliferation and the apoptotic pathway.

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