OXYBUTYNIN IN THE MANAGEMENT OF OVERACTIVE BLADDER IN ADULT WOMEN: A SYSTEMATIC REVIEW

Main Article Content

Leslye Tatiana Vélez Medina
Viviana Matilde Rodríguez Vintimilla
Freddy Rosendo Cárdenas Heredia

Keywords

Oxybutynin, Overactive bladder, women

Abstract

Overactive bladder is a significant issue affecting many adult women, leading to considerable morbidity and a decrease in quality of life. In Ecuador, oxybutynin is frequently prescribed to address this syndrome. However, it is unclear whether its efficacy is consistent when administered individually or in combination with non-pharmacological approaches, and the lack of clinical guidelines exacerbates the situation. This study aims to analyze the efficacy of managing overactive bladder in adult women through the administration of oxybutynin by conducting a systematic review. To achieve this, a thorough search was conducted in electronic databases, such as Pubmed, Medline, Cochrane, Elsevier, and ScienceDirect, with the aim of identifying relevant scientific articles and management guidelines published in the last five years in English and Spanish. The selection of articles will be made by reviewing inclusion criteria, titles, and abstracts, and will be documented through a detailed flowchart. The selected articles will be examined in their entirety, and the relevant information will be included in the results. This detailed study will provide an updated review of the effectiveness of oxybutynin, whether used alone or in conjunction with non-medicinal methods, in adult women suffering from overactive bladder. In addition, appropriate management protocols will be highlighted. The results of this review will be of great interest to physicians, patients, and policymakers, providing key information for making informed decisions about the most effective management of this syndrome in the population most prone to experiencing it, namely, adult women.

Abstract 97 | PDF Downloads 57

References

1. Ministry of Public Health of Ecuador. Clinical Practice Guidelines [Internet]. 2019 [cited 2023 Apr 14]. Available from: https://www.salud.gob.ec/guias-de-practica-clinica-2019/
2. Roosen A, Chapple CR, Dmochowski RR, Fowler CJ, Gratzke C, Roehrborn CG, et al. A Refocus on the Bladder as the Originator of Storage Lower Urinary Tract Symptoms: A Systematic Review of the Latest Literature. Vol. 56, European Urology. 2009. p. 810–20.
3. Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, et al. Prevalence and burden of overactive bladder in the United States. Vol. 20, World Journal of Urology. 2003. p. 327–36.
4. D.E. Irwin, I. Milsom, S. Hunskaar, K. Reilly, Z. Kopp, S. Herschorn. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Results of the EPIC study. Eur Urol., 50 (2006), pp. 1306-1314 http://dx.doi.org/10.1016/j.eururo.2006.09.019 | Medline
5. Castro D, Espuña M, Prieto M, Badia X. Prevalence of overactive bladder in Spain: Population-based study. Arch Esp Urol. 2005; 58(2):131–8.
6. Jirschele K, Sand PK. Oxybutynin: Past, present, and future. Int Urogynecol J Pelvic Floor Dysfunct. 2013; 24(4):595–604.
7. Boaretto J, Mesquita C, Lima A, Prearo L, Girão M, Sartori M. Comparison of oxybutynin, electrostimulation of the posterior tibial nerve and perineal exercises in the treatment of overactive bladder syndrome. In org/10.1590/1809-2950/17020026022019 h/, editor..; 2019.
8. Arruda R, Sousa G, Castro R, Sartori M, Baracat E, Girão M. Detrusor hypertherapy: comparison between oxybutynin, functional electrostimulation of the pelvic assoalho and perineais exercises. In Randomized Study. Revista Brasileira de Ginecologia e Obstetrícia 244ho17, editor..; 2007.
9. Hu J, Pierre E. Urinary incontinence in women: evaluation and management. American Family Physician, 100(6), 339-348. In https://www.aafp.org/pubs/afp/issues/2019/0915/p339.html , editor..; 2019.
10. Álvarez L, Gutiérrez A, García D, Pérez R, Guillen A. Kegel exercise efficiency evaluated through urodynamic study in patients with urinary incontinence. Mexican Journal of Urology, 79(2). In.; 2019.
11. Carvajal D, Navarro A. Effectiveness of Kegel exercises in reducing urinary incontinence in menopausal women: an integrative review. In https://hdl.handle.net/10669/83158 , editor..; 2020.
12. Gonzalez S. Efficacy of Kegel exercises vs. Kegel exercises combined with other treatments for the control of urinary incontinence. Systematic review. In
https://uvadoc.uva.es/handle/10324/59997 , editor..; 2023.
13. Merino S. Maintenance of efficacy in the area of application of the oxybutynin patch for the treatment of overactive bladder syndrome: a study of four cases. Spanish Archives of Urology. 2018; 71(5): p. 502-505.
14. Rodriguez A. The use of Kegel exercises to strengthen the pelvic floor in female patients with pain-related urinary incontinence and the impact obtained on their quality of life: a review of the literature. Yearbook2020, 1. In
http://anuarioinvestigacion.um.edu.mx/index.php/a2020/article/view/76 , editor..; 2020.
15. López L, De La Torre A, Morales C, Díaz A, Peragón M, Almazán A. Effects of a Kegel exercise program for urinary incontinence in women over 65 years of age. Digital Auditorium, 1-3. In 27/11/2023] hc[, editor..; 2019.
16. Méndez A. Analysis of the results of Kegel exercises in the treatment of urinary incontinence in female patients aged 40 to 75 years at the Zabdi clinic in the years 2018 to 2021. In http://repositorio.puce.edu.ec/handle/22000/21984 , editor..; 2022.
17. Vozmediano R, Blanca M, Blasco P. Efficacy of transdermal oxybutynin in the treatment of overactive bladder syndrome: does it make sense to use it in 2017? Adv Urol. 2018;
18. Abu A, Nasr E. Kegel Exercise Training Program among Women with Urinary Incontinence. In Healthcare (Vol. 10, No. 12, p. 2359). MDPI. In https://doi.org/10.3390%2Fhealthcare10122359 , editor..; 2022.
19. Grijalva E, Zambrano D. Kegel exercises versus Pelvic Floor Rehabilitation Program in women with urinary incontinence at the Hipólito Unanue National Hospital, 2020. In https://hdl.handle.net/20.500.14095/1759 , editor..; 2022.
20. Dmochowski RR, Nitti V, Staskin D, Luber K, Appell R, Davila GW. Transdermal oxybutynin in the treatment of adults with overactive bladder: Combined results oftwo randomized clinicaltrials. World J Urol. 2005; 23:263---70. https://link.springer.com/article/10.1007/s00345-005-0012-8