ASSESSMENT OF PREDICTING SUCCESS FACTORS OF MICROVASCULAR COMPOSITE FIBULA FLAP IN RECONSTRUCTION OF HARD AND SOFT TISSUE DEFECTS IN MAXILLOFACIAL AND ORAL CAVITY DUE TO PREVIOUS BALLISTIC TRAUMA

Main Article Content

Elahe Tahmasebi
Reza Tabrizi
Mohsen Yazdanian
Shervin Shafiei
Hamidreza Moslemi
Mohammad Hosein Kalantar Motamedi
Fateme Mozaffari
Arman Torabizadeh

Keywords

Vascular anastomosis, traumatic defects, reconstruction, confounding factors

Abstract

Background and objective


Reconstruction with fibula free-flap is one of the routine treatments in head and neck surgeries. The present research was done to determine the predictor factors of success of vascular anastomosis in composite free fibula microvascular flaps or fibula free flaps used in the reconstruction of traumatic/ballistic oral and maxillofacial defects among the patients referring to Taleghani hospital in Tehran in 2022 and 2023.


Materials and methods


The present research was done via a prospective cohort method on 14 patients. The demographic information, characteristics related to trauma surgery, characteristics associated with the treatment outcomes including success of the flap, incidence of infection, hematoma, and thrombosis at the transplantation site, as well as the site of arterial and venous anastomosis were recorded. Comparison of the quantitative variables was done using independent t-test and Mann-Whitney U test, with the results of qualitative variables judged via chi-square test.


Results


The success of flap was observed in 78.6% (n=11) subjects. Bleeding was seen in two cases (14.3%), surgical site infection in five patients (35.7%), hematoma in one patient (7.1%), and thrombosis in five patients (35.7%). Considering the site of venous and arterial anastomosis, 13 cases (92,9%) were in the form of end to end, and one case (7.1%) was in the form of end to side. No significant difference was observed in terms of frequency of the cases of flap success, infection, hematoma, thrombosis per the transplant and site of arterial anastomosis, type of artery, and anastomosis vein at the recipient site, location of defects, gender, and time between trauma and surgery. Nevertheless, the values of systolic blood pressure (p<0.001), diastolic blood pressure (p<0.001), as well as oxygen saturation percentage (p=0.001) were significantly higher in successful flap cases. Furthermore, smoking tobacco had caused significant reduction in flap success (p=0.02).


Conclusion


Overall, transplantation of composite microvascular flap or fibular free flap has been associated with successes in reconstruction of oral and maxillofacial traumatic defects. However, there are some concerns about the role of some variables such as systolic blood pressure, diastolic blood pressure, as well as oxygen saturation percentage, and smoking tobacco in this regard.


 

Abstract 194 | pdf Downloads 67

References

Patel SY, Kim DD, Ghali GE. Maxillofacial Reconstruction Using Vascularized Fibula Free Flaps and Endosseous Implants. Oral Maxillofac Surg Clin North Am 2019;31:259-84.
2. Kim SY, Kim YG, Kim PT, Ihn JC, Cho BC, Koo KH. Vascularized compared with nonvascularized fibular grafts for large osteonecrotic lesions of the femoral head. J Bone Joint Surg Am 2005;87:2012-8.
3. Marciniak D, Furey C, Shaffer JW. Osteonecrosis of the femoral head. A study of 101 hips treated with vascularized fibular grafting. J Bone Joint Surg Am 2005;87:742-7.
4. Urbaniak JR, Coogan PG, Gunneson EB, Nunley JA. Treatment of osteonecrosis of the femoral head with free vascularized fibular grafting. A long-term follow-up study of one hundred and three hips. J Bone Joint Surg Am 1995;77:681-94.
5. Harris JR, Seikaly H, Calhoun K, Daugherty E. Effect of diameter of microvascular interposition vein grafts on vessel patency and free flap survival in the rat model. J Otolaryngol 1999;28:152-7.
6. Mücke T, Borgmann A, Wagenpfeil S, Günzinger R, Nöbauer C, Lange R, et al. Autonomization of epigastric flaps in rats. Microsurgery 2011;31:472-8.
7. Hölzle F, Rau A, Loeffelbein DJ, Mücke T, Kesting MR, Wolff KD. Results of monitoring fasciocutaneous, myocutaneous, osteocutaneous and perforator flaps: 4-year experience with 166 cases. Int J Oral Maxillofac Surg 2010;39:21-8.
8. Jones BM, Mayou BJ. The Laser Doppler flowmeter for microvascular monitoring: a preliminary report. Br J Plast Surg 1982;35:147-9.
9. Knobloch K, Gohritz A, Vogt PM. Noninvasive monitoring of microcirculatory perfusion and oxygenation in subcutaneous microsurgical flaps. J Reconstr Microsurg 2008;24:69.
10. Moolenburgh SE, van Huizum MA, Hofer SO. DIEP-flap failure after pedicle division three years following transfer. Br J Plast Surg 2005;58:1000-3.
11. Lodders JN, Leusink FKJ, Ridwan-Pramana A, Winters HAH, Karagozoglu KH, Dekker H, et al. Long-term outcomes of implant-based dental rehabilitation in head and neck cancer patients after reconstruction with the free vascularized fibula flap. J Craniomaxillofac Surg 2021;49:845-54.
12. Corbitt C, Skoracki RJ, Yu P, Hanasono MM. Free flap failure in head and neck reconstruction. Head Neck 2014;36:1440-5.
13. Goker F, Baj A, Bolzoni AR, Maiorana C, Giannì AB, Del Fabbro M. Dental implant-based oral rehabilitation in patients reconstructed with free fibula flaps: Clinical study with a follow-up 3 to 6 years. Clin Implant Dent Relat Res 2020;22:514-22.
14. Goker F, Baj A, Bolzoni AR, Maiorana C, Racco P, Taschieri S, et al. Effectiveness of dental implants placed into microvascular free flaps. Oral Dis 2020;26:1532-6.
15. Attia S, Wiltfang J, Pons-Kühnemann J, Wilbrand JF, Streckbein P, Kähling C, et al. Survival of dental implants placed in vascularised fibula free flaps after jaw reconstruction. J Craniomaxillofac Surg 2018;46:1205-10.
16. Parbo N, Murra NT, Andersen K, Buhl J, Kiil B, Nørholt SE. Outcome of partial mandibular reconstruction with fibula grafts and implant-supported prostheses. Int J Oral Maxillofac Surg 2013;42:1403-8.
17. Hidalgo DA, Rekow A. A review of 60 consecutive fibula free flap mandible reconstructions. Plast Reconstr Surg 1995;96:585-96; discussion 97-602.
18. González-García R, Naval-Gías L, Rodríguez-Campo FJ, Muñoz-Guerra MF, Sastre-Pérez J. Vascularized free fibular flap for the reconstruction of mandibular defects: clinical experience in 42 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:191-202.
19. De Santis G, Nocini PF, Chiarini L, Bedogni A. Functional rehabilitation of the atrophic mandible and maxilla with fibula flaps and implant-supported prosthesis. Plast Reconstr Surg 2004;113:88-98; discussion 9-100.
20. Chang EI. Impact of venous outflow tract on survival of osteocutaneous free fibula flaps for mandibular reconstruction: A 14-year review. Head Neck 2017;39:1454-8.
21. Chiapasco M, Biglioli F, Autelitano L, Romeo E, Brusati R. Clinical outcome of dental implants placed in fibula-free flaps used for the reconstruction of maxillo-mandibular defects following ablation for tumors or osteoradionecrosis. Clin Oral Implants Res 2006;17:220-8.
22. Pompa G, Saccucci M, Di Carlo G, Brauner E, Valentini V, Di Carlo S, et al. Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study. BMC Oral Health 2015;15:5.
23. Mücke T, Rau A, Weitz J, Ljubic A, Rohleder N, Wolff KD, et al. Influence of irradiation and oncologic surgery on head and neck microsurgical reconstructions. Oral Oncol 2012;48:367-71.
24. Mücke T, Wolff KD, Wagenpfeil S, Mitchell DA, Hölzle F. Immediate microsurgical reconstruction after tumor ablation predicts survival among patients with head and neck carcinoma. Ann Surg Oncol 2010;17:287-95.
25. Anavekar NS, Lim E, Johnston A, Findlay M, Hunter-Smith DJ. Minimally invasive late free flap salvage: indications, efficacy and implications for reconstructive microsurgeons. J Plast Reconstr Aesthet Surg 2011;64:1517-20.
26. Wolff KD, Hölzle F, Wysluch A, Mücke T, Kesting M. Incidence and time of intraoperative vascular complications in head and neck microsurgery. Microsurgery 2008;28:143-6.
27. Bui DT, Cordeiro PG, Hu QY, Disa JJ, Pusic A, Mehrara BJ. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps. Plast Reconstr Surg 2007;119:2092-100.
28. Taylor GI, Miller GD, Ham FJ. The free vascularized bone graft. A clinical extension of microvascular techniques. Plast Reconstr Surg 1975;55:533-44.
29. Hidalgo DA. Fibula free flap: a new method of mandible reconstruction. Plast Reconstr Surg 1989;84:71-9.
30. Chang EI, Zhang H, Liu J, Yu P, Skoracki RJ, Hanasono MM. Analysis of risk factors for flap loss and salvage in free flap head and neck reconstruction. Head Neck 2016;38 Suppl 1:E771-5.
31. Patel SA, Abdollahi H, Ridge JA, Chang EI, Lango MN, Topham NS. Asymptomatic Deep Peroneal Vein Thrombosis During Free Fibula Flap Harvest: A Review of the Literature, Strategies for Preoperative Assessment, and an Algorithm for Reconstruction. Ann Plast Surg 2016;76:468-71.
32. Wu CC, Lin PY, Chew KY, Kuo YR. Free tissue transfers in head and neck reconstruction: complications, outcomes and strategies for management of flap failure: analysis of 2019 flaps in single institute. Microsurgery 2014;34:339-44.
33. Suh JD, Sercarz JA, Abemayor E, Calcaterra TC, Rawnsley JD, Alam D, et al. Analysis of outcome and complications in 400 cases of microvascular head and neck reconstruction. Arch Otolaryngol Head Neck Surg 2004;130:962-6.
34. Burgess M, Leung M, Chellapah A, Clark JR, Batstone MD. Osseointegrated implants into a variety of composite free flaps: A comparative analysis. Head Neck 2017;39:443-7.
35. Khadembaschi D, Russell P, Beech N, Batstone MD. Osseointegrated implant survival, success and prosthodontic outcomes in composite free flaps: A 10-year retrospective cohort study. Clin Oral Implants Res 2021;32:1251-61.
36. Eisenschenk A, Lautenbach M, Rohlmann A. [Free vascularized bone transplantation in the extremities]. Orthopade 1998;27:491-500.
37. Guo F. Fibular blood supply. Chin Med J (Engl) 1981;94:396-400.
38. Samaha FJ, Oliva A, Buncke GM, Buncke HJ, Siko PP. A clinical study of end-to-end versus end-to-side techniques for microvascular anastomosis. Plast Reconstr Surg 1997;99:1109-11.
39. Pourali G, Ahmadzade AM, Arastonejad M, Pourali R, Kazemi D, Ghasemirad H, Khazaei M, Fiuji H, Nassiri M, Hassanian SM, Ferns GA. The circadian clock as a potential biomarker and therapeutic target in pancreatic cancer. Molecular and Cellular Biochemistry. 2023 Jul 5:1-3.
40. Basmenj ER, Arastonejad M, Mamizadeh M, Alem M, KhalatbariLimaki M, Ghiabi S, Khamesipour A, Majidiani H, Shams M, Irannejad H. Engineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis. Scientific Reports. 2023 Nov 8;13(1):19421.
41. Darban M, Ghahremanfard F, Razmjoyi S, Bagheri B. Investigating neutrophil to lymphocyte ratio associated with the prognostic factors in women with breast cancer. Journal of Advanced Pharmacy Education & Research, 2019, 9(S2):140-144
42. Lima B, Razmjouei S, Bajwa MT, Shahzad Z, Shoewu OA, Ijaz O, Mange P, Khanal S, Gebregiorgis T. Polypharmacy, Gender Disparities, and Ethnic and Racial Predispositions in Long QT Syndrome: An In-Depth Review. Cureus. 2023 Sep 26;15(9).
43. Borhani A, Afyouni S, Attari MM, Mohseni A, Catalano O, Kamel IR. PET/MR enterography in inflammatory bowel disease: A review of applications and technical considerations. European Journal of Radiology. 2023 Apr 25:110846.
44. Mollazadeh M, Azizian H, Fakhrioliaei A, Iraji A, Avizheh L, Valizadeh Y, Zomorodian K, Elahi F, Moazzam A, Kazemzadeh H, Amanlou M. Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic simulations. Medicinal Chemistry Research. 2023 May;32(5):930-43.
45. Safapoor S, Halimi M, Ghomi MK, Noori M, Dastyafteh N, Javanshir S, Hosseini S, Mojtabavi S, Faramarzi MA, Nasli-Esfahani E, Larijani B. Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides. RSC Advances. 2023;13(28):19243-56.
46. Ghalehbandi M, Khosravifar S, Aloosh O, Rahimi‐Golkhandan A, Abounoori M, Aloosh A, Afshar H, Khosravifar S. The association between sleep quality, health status and disability due to breathlessness in chronic obstructive pulmonary disease patients. The Clinical Respiratory Journal. 2021 Nov;15(11):1168-74.
47. Omranifard V, Abounoori M, Babakhanian M, Ebrahimi A, Akouchekian S, Shafiei K, Khosravifar S. Translation and psychometric properties of the Persian version of the Health of the Nation Outcome Scales for Elderly People (HoNOS65+). Aging Medicine. 2021 Jun;4(2):135-45.
48. Zhang L, Pakmehr SA, Shahhosseini R, Hariri M, Fakhrioliaei A, Karkon Shayan F, Xiang W, Karkon Shayan S. Oncolytic viruses improve cancer immunotherapy by reprogramming solid tumor microenvironment. Medical Oncology. 2023 Dec 8;41(1):8
49. Shayan SK, Nasrollahi E, Bahramvand Y, Zarei M, Atarodi A, Farsi Y, Tavakolizadeh M, Shirvaliloo M, Abbasifard M, Jamialahmadi T, Banach M. Percutaneous Coronary Intervention Associated with a Higher Risk of Hypoxemia and COVID-19 Severity. Current Medicinal Chemistry. 2023.
50. Karkon-Shayan S, Aliashrafzadeh H, Dianat-Moghadam H, Rastegar-Pouyani N, Majidi M, Zarei M, Bahramvand Y, Babaniamansour S, Jafarzadeh E. Resveratrol as an antitumor agent for glioblastoma multiforme: Targeting resistance and promoting apoptotic cell deaths. Acta Histochemica. 2023 Aug 1;125(6):152058.
51. Shayan SK, Nasrollahi E, Bahramvand Y, Zarei M, Atarodi A, Farsi Y, Tavakolizadeh M, Shirvaliloo M, Abbasifard M, Jamialahmadi T, Banach M. Percutaneous Coronary Intervention Associated with a Higher Risk of Hypoxemia and COVID-19 Severity. Current Medicinal Chemistry. 2024.
52. Shayan SK, Aliashrafzadeh H, Rezayitalab F, Sobhani M, Zarei M. Comparison of the Outcome of Altplas Administration after Acute Ischemic Stroke in Patients Over 80 Years and Under 80 Years Admitted. Journal of Pharmaceutical Negative Results. 2022 Sep 22:684-8.
53. Mollazadeh, M., Azizian, H., Fakhrioliaei, A. et al. Different barbiturate derivatives linked to aryl hydrazone moieties as urease inhibitors; design, synthesis, urease inhibitory evaluations, and molecular dynamic simulations. Med Chem Res 32, 930–943 (2023). https://doi.org/10.1007/s00044-023-03050-w

54. Doraghi F, Pegah Aledavoud S, Fakhrioliaei A, Larijani B, Mahdavi M. Ring‐Opening Cross‐Coupling/Cyclization Reaction of Cyclopropanols with Organic Compounds. ChemistrySelect. 2023 Aug 31;8(32):e202301438.

55. Safapoor S, Halimi M, Ghomi MK, Noori M, Dastyafteh N, Javanshir S, Hosseini S, Mojtabavi S, Faramarzi MA, Nasli-Esfahani E, Larijani B. Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides. RSC Advances. 2023;13(28):19243-56.
56. Omranifard V, Abounoori M, Babakhanian M, Ebrahimi A, Akouchekian S, Shafiei K, Khosravifar S. Translation and psychometric properties of the Persian version of the Health of the Nation Outcome Scales for Elderly People (HoNOS65+). Aging Medicine. 2021 Jun;4(2):135-45.
57. Ghamari N, Ghaderpanah R, Sadrian SH, Fallah N. Effect of a visual dual task on postural stability—a comparative study using linear and nonlinear methods. Health Sci Rep. 2023; 6:e1437.
58. Tahmasbi F, Mosaddeghi-Heris R, Soleimanzadeh F, Ghaderpanah R, Sadrian S, Hajebrahimi S, Salehi-Pourmehr H. Effects of Posterior Tibial Nerve Stimulation on Fecal Incontinence: An Umbrella Review. Neuromodulation: Technology at the Neural Interface. 2023 Jul 16.
59. Tahmasbi F, Ghaderpanah R, Sadrian S, Heris RM, Salehi-Pourmehr H. Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Chronic Pain in Older Adults: a Systematic Review and Meta-Analysis. Current Physical Medicine and Rehabilitation Reports. 2023 Apr 21:1-2.
60. Ghaderpanah R, Farpour HR, Seifi P, Sadrian S. The Upper Limb Disorders among Schoolteachers Involved in E-learning during the Pandemic of COVID-19: A Cross-Sectional Study. Journal of Biomedical Physics & Engineering. 2023 Apr 2;13.
61. Baghdadi, Taghi MDa; Zafari, Hamidreza MDa; Ghaderpanah, Rezvan MDb; Moharrami, Alireza MDa; Rafati, Amir Ali MDa; Nabian, Mohammad Hossein MDc; Ebrahiminasab, Mehdi MDa; Zargarbashi, Ramin MDd. Clinical and radiological outcomes of lateral column lengthening (LCL) surgery in pediatrics: a cohort study. Annals of Medicine & Surgery ():10.1097/MS9.0000000000000708, July 24, 2023.

Most read articles by the same author(s)