ANTIMICROBIAL ACTIVITY, PHYSIOCHEMICAL AND SPECTRAL CHARACTERIZATION OF RARE EARTH METAL CHELATES BASED ON THIOCARBOHYDRAZIDE DERIVATIVES

Main Article Content

Dr. Sharad Sankhe1
Mr. Shashank Parab

Keywords

Antimicrobial activity, biologically active molecule, Molar conductivity, Lanthanide complexes, Mononuclear

Abstract

The physiologically active N”-[(Z)-(4-Fluorophenyl)methylidene]-N”-[(1E,2E)-[hydroxylamine-1,2-diphenylidene]thiocarbohydrazide (HBMToFB) ligand was prepared by condensation reaction between α-benzilmonoximethiocarbohydrazide and o-fluorobenzaldehyde in the presence of the catalytic amount of HCl. This ligand is used to synthesize lanthanide metal complexes. The kind of trinuclear lanthanide complexes [Ln(BMToFB)3]comprises ten different compounds. In this case, the functional groups of the synthesized Ln = La(III), Lu(III), Ce(III), Sm(III), Nd(III), Ho(III), Yb(III), Dy(III) Pr(III), and Gd(III) were shown in detail through UV-visible and infrared spectroscopy, PMR spectroscopy, elemental analysis (C, H, N, S analysis), magnetic susceptibility, and molar conductivity. Using powder XRD characteristics of the complexes were examined. N”-[(Z)-(4-Fluorophenyl)methylidene]-N”-[(1E,2E)-[hydroxylamine-1,2-diphenylidene] thiocarbohydrazide acted as a tridentate, monobasic ligand, and its two oxygen, two sulfur, and nitrogen atoms formed a structure that could interact with metal ions, according to infrared spectroscopy. The antibacterial activity of the synthesized metal complexes was successfully tested.

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