ANTIMICROBIAL ACTIVITY, PHYSIOCHEMICAL AND SPECTRAL CHARACTERIZATION OF RARE EARTH METAL CHELATES BASED ON THIOCARBOHYDRAZIDE DERIVATIVES

Abstract

The physiologically active N”-[(Z)-(4-Fluorophenyl)methylidene]-N”-[(1E,2E)-[hydroxylamine-1,2-diphenylidene]thiocarbohydrazide (HBMToFB) ligand was prepared by condensation reaction between α-benzilmonoximethiocarbohydrazide and o-fluorobenzaldehyde in the presence of the catalytic amount of HCl. This ligand is used to synthesize lanthanide metal complexes. The kind of trinuclear lanthanide complexes [Ln(BMToFB)₃]comprises ten different compounds. In this case, the functional groups of the synthesized Ln = La(III), Lu(III), Ce(III), Sm(III), Nd(III), Ho(III), Yb(III), Dy(III) Pr(III), and Gd(III) were shown in detail through UV-visible and infrared spectroscopy, PMR spectroscopy, elemental analysis (C, H, N, S analysis), magnetic susceptibility, and molar conductivity. Using powder XRD characteristics of the complexes were examined. N”-[(Z)-(4-Fluorophenyl)methylidene]-N”-[(1E,2E)-[hydroxylamine-1,2-diphenylidene] thiocarbohydrazide acted as a tridentate, monobasic ligand, and its two oxygen, two sulfur, and nitrogen atoms formed a structure that could interact with metal ions, according to infrared spectroscopy. The antibacterial activity of the synthesized metal complexes was successfully tested.