MICROSPONGE BASED DRUG DELIVERY SYSTEM: A FUTURISTIC APPROACH IN DISEASE DIAGNOSING AND MANAGEMENT
Main Article Content
Keywords
Drug delivery, Controlled release, Stability, Biodegradable, Non-toxicity
Abstract
A medication delivery technology called a microsponge has the adaptability to load a variety of active chemicals because of its huge surface area. It lowers systemic exposure and negative effects and enables the regulated release of active substances. Microsponges are polymeric sponges with flexible, porous structures made of interconnected gaps. With fewer negative effects, microsponge administration systems offer increased product stability, safety, formulation flexibility, effectiveness, and aesthetic appeal. Due to minimal bacterial contamination and the lack of preservatives in the recipe, it is regarded as safe. As a result, it is utilised in several sterile formulations, including ophthalmic and parenteral. This study gives a general overview of the microsponge technology, including its technique, mechanism, programmed release, characterisation, and latest information on formulations that have been commercially successful, their uses, and a list of patents. It also evaluates and applies microsponges in diverse contexts. Although lately utilised for oral applications as well, microsponge is frequently employed for topical applications.
References
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55. BorawakePayal D, KauslyaArumugam, ShindeJitendra V, ChavanRajashree S; Microsponge as an Emerging Technique in Novel Drug Delivery System, Journal of Drug Delivery and Therapeutics. 2021,11(1):171-
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3. Franz TJ. Percutaneous absorption. On the relevance of in vitro date. J Invest Dermatol 1975;45:498-503.
4. Yazici E, Kas HS, Hincal AA. Microsponges, FarmasotikBilimlerDergisi (Turkey). 1994;19:121-8.
5. Wester R, Patel R, Natch S, Leyden J, Melendres J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. J Am AcadDerm 1991;24:720-6.
6. D'souza JI, Saboji JK, Killedar SG, More NH. Design and Evaluation of Benzoyl Peroxide Microsponges to Enhance Therapeutic Efficacy in Acne Treatment. 20th FAPA Congress, Bangkok, Thailand: FAPA Congress; Nov 30 - Dec 3, 2004.
7. D'souza JI. In-vitro Antibacterial and Skin Irritation Studies of Microsponges of Benzoyl Peroxide. Indian Drugs 2001;38:23.
8. Fincham JE, Karnik KA. Patient Counseling and Derm Therapy. US Pharm 1994;19:56-57, 61-2, 66, 71-2, 74, 77-8, 81-2.
9. D’souza JI, Masvekar RR, Pattekari PP, Pudi SR, More HN. Microspongic Delivery of Fluconazole For Topical Application, 1st Indo-Japanese International Conference On Advances In Pharmaceutical Research And Technology. Mumbai, India: Pharmaceutical Research And Technology; 2005. p. 25-9.
10. Grimes PE. A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and post-inflammatory hyperpigmentation. Cutis 2004;74:362-8.
11. Embil VP. OTC External analgesic cream/topical analgesic-antiinflammatory, counterirritant utilizing the Microsponge Delivery System (MDS) for controlled release of actives. Patent Application No: 0101058.6. UK: 2000.
12. Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by changing their Intraparticle Density. Chem Pharm Bull 1992;40:196-201.
13. Aritomi H, Yamasaki Y, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. J Pharm Sci Tech 1996;56:49-56.
14. OrluM, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 2006;318:103-17.
15. Chen G, Ushida T, Tateishi T. A Biodegradable Hybrid Sponge Nested With Collagen Microsponges. J Biomed Mater Res 2000;51:273-9.
16. Kanematsu A, Marui A, Yamamoto S, Ozeki M, Hirano Y, Yamamoto M, et al. Type I collagen can function as a reservoir of basic fibroblast growth factor. J Control Release 2004;94:281-92.
17. Iwai S, Sawa Y, Ichikawa H, Taketani S, Uchimura E, Chen G, et al. Biodegradable polymer with collagen microsponge serves as a new bioengineered cardiovascular prosthesis. J ThoracCardiovascSurg 2004;128:472-9.
18. Chen G, Sato T, Ohgushi H, Ushida T, Tateishi T, Tanaka J. Culturing of skin fibroblasts in a thin PLGA–collagen hybrid mesh. Biomaterials 2005;26:2559-66.
19. Iwai S, Sawa Y, Taketani S, Torikai K, Hirakawa K, Matsuda H. Novel Tissue-Engineered Biodegradable Material for Reconstruction of Vascular Wall. Ann ThoracSurg 2005; 80:1821-7.
20. Grimee PE, Meraz M. A new microentrapped 4% hydroquinone formulation for treatment of hyperpigmentation. 60th Annual meeting of American Academy of Dermatology. La Poeter 519. New Orleane: Feb 22-27, 2002.
21. Atmaram P, Pawar, Aditya P, Gholap, Ashwin B, Kuchekar C et al. Formulation and evaluation of optimized oxybenzonemicrosponge gel for topical delivery. J of drug delivery. 2015;[7]:12-48.
22. Won R. Two step method for preparation of controlled release formulation. United States patent number. US5145675; 1992.
23. Jelvehgari MR, Siahi-Shadbad S, Azarmi GP, et al. The microsponge delivery system of benzoyl peroxide: preparation, characterization and release studies. Int J Pharm 2006;[308]:124- 32.
24. Maiti S, Kaity S, Ray S, et al. Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium. Acta Pharm 2011;[61]:257-70.
25. ZakiRizkalla CM, Latif Aziz R, Soliman II. In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. AAPS PharmSciTech 2011;12[3]:989-1001.
26. Bae SE, Son JS, Park K, et al. Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery and regenerative medicine. J Control Release 2009;[133]:37-43.
27. Liu LS, Liu SQ, Ng SY, et al. Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres. J Control Release 1997;[43]:65-74.
28. Lopez GP, Buranda T, Gopalaraju VRR, et al. Biologically functionalized porous microspheres. US2004005352; 2004.
29. Sha-Sha Li, Guo-Feng Li, Li Liu, Xias Jiang, Bin Zhang, Zhi-Gang Liu et al. Evaluation of paeonol skin-target delivery from its microsponge formulation: In vitro Skin Permeation and In vivo Microdialysis, Plosone. 2013; [8]:789-98.
30. Pushpa, Kumari, ShashiKiran Mishra. A comprehensive review on novel microsponges drug delivery approach. Asian, J. Pharm. Cli. Res. 2016; [9]:25-30.
31. Vyas SP, Khar RK. Targeted and Controlled Drug Delivery-Novel Carrier System: New Delhi: CBS Publication, First edition; 2002:453.
32. A.P. Pharma, Inc. Microsponge Technology, Topical Technology December 2001. Available at: http://www.appharma.com/PDFs/topic alsht.pdf.
33. D’souza JI, Harinath NM. Topical Anti-Inflammatory Gels of FluocinoloneAcetonide Entrapped in Eudragit Based Microsponge Delivery System. Research J. Pharm. and Tech 2008;1(4):502-506.
34. Amrutiya N, Bajaj A, Madan M. Development of Microsponges for Topical Delivery of Mupirocin. AAPS PharmSciTech 2009;10(2):402-408.
35. Jelvehgari M, Siahi-Shadbad MR, Azarmi S, Gary P, Martin, Nokhodchi A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. International Journal of Pharmaceutics 2006;308:124-132.
36. Shah VP. Determination of In-vitro Release from Hydrocortisone Creams. International Journal of Pharmaceutics 1989;53:53-59.
37. Khopade AJ, Jain S, Jain NK. The Microsponge. Eastern Pharmacist 1996:49-53.
38. Yazici E, Kas HS, Hincal AA. Microsponges. FarmasotikBilimlerDergisi (Turkey) 1994;19(3):121-128.
39. Wester R, Patel R, Natch S, Leyden J, Melendres J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. 1991; 24: 720-726.
40. D'souza JI, Jagdish K, Saboji, Suresh G, Killedar, Harinath N. Design and Evaluation of Benzoyl Peroxide Microsponges to Enhance Therapeutic Efficacy in Acne Treatment, Accepted for presentation in 20th FAPA Congress, Bangkok , Thailand 2004.
41. D'souza JI et al. In-vitro Antibacterial and Skin Irritation Studies of Microsponges of Benzoyl Peroxide. Indian Drugs 2001; 38(7): 104-109.
42. Kilicarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of Verapamil HCl loaded microspheres; International Journal of Pharmaceutics 2003;252:99-109.
43. D’souza JI, Masvekar RR, Pattekari PP, Pudi SR, More HN. Microspongic Delivery of Fluconazole for Topical Application, 1st Indo-Japanese International Conference On Advances In Pharmaceutical Research And Technology, Mumbai, India 2005:25-29.
44. Grimes PE. A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and post-inflammatory hyperpigmentation 2004;74(6):362- 368.
45. James J, Leyden , Alan S, Diane T, Kenneth W,Guy W. Topical Retinoids in Inflammatory Acne: A Retrospective, Investigator-Blinded, Vehicle-Controlled, Photographic Assessment, Clinical Therapeutics 2005;27:216-224.
46. Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by changing their Density 1992;40(1):196-201.
47. Aritomi H, Yamasaki Y, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. Journal of Pharmaceutical Sciences and Technology 1996;56(1):49-56.
48. Nacht S, Kantz M. The Microsponge: A Novel Topical Programmable Delivery System. 1992;42:299-325.
49. Mine O, Erdal C, Ahmet A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. International Journal of Pharmaceutics 2006;318:103-117.
50. Ashwini S Bansode, Vaishnavi B Kute, Komal S Vethekar, Priyanka S Kote, Monika K Varhadi, Ajit S Bansode, Suresh L Jadhav, Nitin V Devhadrao; Formulation, development and evaluation of Microsponge loaded Topical Gel of Nystatin, Journal of Drug Delivery and Therapeutics. 2019,9(2):451-461
51. PawarVitthal, SalunkheAnuradh; a review on microsponges drug delivery system; -2020,1(7):961-974
52. N.H. Aloorkar, A.S. Kulkarni, D.J. Ingale and R.A. Patil; Microsponges as Innovative Drug Delivery Systems, International journal of pharmaceutical science and nanotechnology. 2012,5(1):1597-1606
53. Yeteng He, Khadija Majid, MaimoonaMaqbool, Talib Hussain, AbidMehmoodYousaf, IkramUllah Khan, YasirMehmood, AmbreenAleem, Muhammad Sohail Arshad, Adnan Younus, Jorabar Singh Nirwan, Muhammad Usman Ghori, Syed A.A. Rizvi, Yasser Shahzad, Formulation and characterization of lornoxicam-loaded cellulosic microsponge gel for possible applications in arthritis; Saudi Pharmaceutical Journal. 2020,(28):994-1003
54. Jyoti and Kumar Sandeep, innovative and novel strategy: microsponges for topical drug delivery, Journal of Drug Delivery and Therapeutic.2018,8(5):28-34
55. BorawakePayal D, KauslyaArumugam, ShindeJitendra V, ChavanRajashree S; Microsponge as an Emerging Technique in Novel Drug Delivery System, Journal of Drug Delivery and Therapeutics. 2021,11(1):171-
56. Mishra SK, Kumari P, A comprehensive review on novel microsponge drug delivery approach, Asian Journal of Pharmaceutical and Clinical Research. 2016, 9(1):25-30.
57. Charde MS, Ghanawat PB, Welankiwar AS, Kumar J, Chakole RD, Microsponge a novel new drug delivery system: a review, International Journal of Advances in Pharmaceutics. 2013, 2(6):63-70. [9] Tiwari A, Mishra MK, Shukla A, Yadav SK, Microsponge: an augmented drug delivery system, American Journal of PharmTech Research. 2016, 6(6):80-95.
58. Gandhi KJ, Deshmane SV, Biyani KR, Polymers in pharmaceutical drug delivery system: a review, International Journal of Pharmaceutical Sciences Review and Research. 2012, 14(2):57-66
59. SantanuKaity, SabyasachiMaiti, Ashoke Kumar Ghosh1, Dilipkumar Pal, Animesh Ghosh, Subham Banerjee; Microsponges: A novel strategy for drug delivery system. 2010,3(1):283-290
60. Parikh B.N, Gothi G.D., Patel T.D, Chavda H.V., and Patel C.N.; microsponge as novel topical drug delivery system, Journal of Global Pharma Technology. 2010; 2(1): 17-29.
61. Pankaj Singh Khanka, Kashif Hussain; Formulation and Evaluation of Antifungal Microsponge Loaded Gel, International Journal of Research in Engineering, Science and Management Volume-2, Issue-12, December-2019
62. Radwa M. A. Abd-Elala, Ghada H. Elosailya, El-Sayed Khafagyc, Yasser Mostafae, ShadeedGadc; records of pharmaceutical and biomedical sciences; Drug Delivery from Microsponges. 2021,5(3):21-27
63. PatilShital S., DandekarVaishali, Kale Asawari, BarhateDr. S. D., Microsponge Drug Delivery System: An Overview European Journal of pharmaceutical and Medical Research. 2016,3(8):212-221
64. Kumar S, Tyagi LK, Singh D, Microsponge delivery system (MDS): a unique technology for delivery of active ingredients, International Journal of Pharmaceutical Sciences and Research. 2011, 2(12):3069-3080.
65. Monika, DuaJagdeep Singh, Prasad D.N., Hans Mansi, Kumari Satish; Preparation and Characterization of Itraconazole Microsponges using Eudragit RSPO and Study the Effect of Stirring on the Formation of Microsponges, Journal of Drug Delivery and Therapeutics. 2019,9(3):451-458.
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Jun 16, 2022
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Deepesh Rajput, Dr. Dharmendra Rajput, & Dr. Pankaj Masih. (2022). MICROSPONGE BASED DRUG DELIVERY SYSTEM: A FUTURISTIC APPROACH IN DISEASE DIAGNOSING AND MANAGEMENT. Journal of Population Therapeutics and Clinical Pharmacology, 29(02), 284–303. https://doi.org/10.53555/jptcp.v29i02.4054
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Author Biographies
Deepesh Rajput
Research Scholar(PhD*)Faculty of Pharmacy, Madhyanchal Professional University, Bhopal(462044),Madhya Pradesh, India
Cont. No:-+91-8871460577
Dr. Dharmendra Rajput
Professor, Madhyanchal Professional University, Bhopal(462044),Madhya Pradesh, India
Dr. Pankaj Masih
Professor, Madhyanchal Professional University, Bhopal(462044),Madhya Pradesh, India