Main Article Content

Andi Ayu Lestari
Junaedi Sirajuddin
Halimah Pagarra


graves’ ophthalmopathy, opthalmology, Vitamin D, Treatment, Eye disease


Background: Graves' Ophthalmopathy (GO) poses unique challenges in its management, prompting an exploration into potential interventions to address both systemic and ocular manifestations. This systematic review aims to assess the impact of oral vitamin D supplementation on critical parameters in GO, including serum vitamin D levels, disease activity, and tear film dynamics. 

Methods: A systematic review was performed by searching relevant studies until Desember 2023 using the PubMed, MEDLINE, and EMBASE databases. Studies involving individuals with GO and has oral vitamin D supplementation were included in this review.

Results: The synthesized findings reveal a consistent positive correlation between oral vitamin D supplementation and elevated serum vitamin D levels in individuals with GO. Notably, this correlation suggests a potential link influencing the autoimmune processes underlying GO. Moreover, our analysis highlights promising effects on disease activity markers and tear film parameters, indicating the multifaceted impact of vitamin D in this complex autoimmune disorder. While acknowledging some study heterogeneity, these results provide valuable insights into the potential therapeutic role of vitamin D in GO.

Conclusion: In conclusion, this systematic review underscores the potential significance of oral vitamin D supplementation in the management of Graves' Ophthalmopathy. Elevated serum vitamin D levels, observed improvements in disease activity, and effects on tear film parameters collectively suggest a promising avenue for future therapeutic interventions.

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