NOVEL APPLICATIONS OF PRECIPITATED CALCIUM CARBONATE IN FOOD, PHARMACEUTICAL, AND COSMETIC INDUSTRY

Main Article Content

Sohail Noor
Amin ur Rehman
Dr. Shahid Iqbal
Dr. Mahmood Iqbal
Engineer Waheed Ur Rehman

Keywords

Precipitated calcium carbonate, Food grade calcium carbonate, Ground calcium carbonate, food, pharmaceutical

Abstract

Globally, different types of industries have been using precipitated calcium carbonate (PCC) from decades. Yet some recent studies have shown that there are some novel uses/applications of PCC in food, pharmaceutical, and cosmetic industries beyond traditional applications. It can be used in old materials which have already been prepared with variations or in the development of new materials. This paper critically summarizes the basic production methods, uses/applications, recent development and ongoing activities, specifications, and regulations for the use of food-grade PCC materials. The review would allow academics, researchers and industrialists to learn about the material and innovations that have occurred in the last few years. Moreover, this paper provides an update of the most recent and relevant findings about the selected material application in different types of industries. The review paper also focuses the future research needs and provides new insights and directions for the application of PCC in related industries.

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References

1. JP (2006) Japanese Pharmacopeia, Precipitated Calcium Carbonate, vol. XV, The Ministry of Health, Labour and Welfare, Japan.
2. Ph. Eur (2015) European Pharmacopeia, Calcium Carbonate, eighth ed., European Directorate for the Quality of Medicines, Strasbourg, France.
3. USP (2015) The United States Pharmacopeia Convention, The United States Pharmacopeia: 38/National Formulary 33 (USP 38/NF 33), Calcium Carbonate, vol. 2, USP Convention Inc., Maryland.
4. USP (2015) The United States Pharmacopeia Convention, The United States Pharmacopeia: 38/National Formulary 33 (USP 38/NF 33), Description and Solubility, vol. 1, USP Convention Inc., Maryland.
5. Afzal, F., Mueen-ud-Din, G., Nadeem, M., Murtaza, M. A., and Mahmood, S. (2020). Effect of eggshell powder fortification on the physicochemical and organoleptic characteristics of muffins. Pure and Applied Biology (PAB), 9(2), 1488-1496. doi:10.19045/bspab.2020.90154.
6. Akkan, T., Dagdeviren, M., Koca, A., Ertugrul, D., & Altay, M. (2020). Alternate-day calcium dosing may be an effective treatment option for chronic hypoparathyroidism. Journal of Endocrinological Investigation, 1-6. doi:10.1007/s40618-019-01173-9.
7. Allen, T. M., & Cullis, P. R. (2004). Drug delivery systems: entering the mainstream. Science, 303(5665), 1818-1822. doi:10.1126/science.1095833
8. Anisja, D., Indrani, D., & Herda, E. (2017). The effect of brushing with nano calcium carbonate and calcium carbonate toothpaste on the surface roughness of nano-ionomer. Paper presented at the Journal of Physics: Conference Series.
9. Avaro, J. T., Ruiz-Agudo, C., Landwehr, E., Hauser, K., & Gebauer, D. (2019). Impurity-free amorphous calcium carbonate, a preferential material for pharmaceutical and medical applications. European Journal of Mineralogy, 31(2), 231-236. doi:10.1127/ejm/2019/0031-2831.
10. Bani-Jaber, A., & Abdullah, S. (2020). Development and characterization of novel ambroxol sustained-release oral suspensions based on drug-polymeric complexation and polymeric raft formation. Pharmaceutical Development and Technology, 1-10.
doi:10.1080/10837450.2020.1729799.
11. Barreto, F. C., Barreto, D. V., Massy, Z. A., & Drueke, T. B. (2019). Strategies for phosphate control in patients with chronic kidney disease. Kidney international reports.
doi:10.1016/j.ekir.2019.06.002.
12. Basria, R., Mydin, S.M.N., Nadhirah, I., Zahidi, M., Nadiah, N., I., Shaida, N., Nik., S., G., Moshawih, S., Siddiquee, S. (2018). Potential of Calcium Carbonate Nanoparticles for Therapeutic Applications. Malaysian Journal of Medicine and Health Sciences, 14(SUPP1), 201-206.
13. Bisht, S., & Maitra, A. (2009). Dextran-doxorubicin/chitosan nanoparticles for solid tumor therapy. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 1(4), 415-425. doi:10.1002/wnan.43.
14. Bolland, M., Grey, A., Avenell, A., Gamble, G., & Reid, I. (2011). Calcium/vitamin D supplements and cardiovascular events: a re-analysis of the Women’s Health Initiative limited-access dataset, and meta-analysis of calcium with or without vitamin D. BMJ, 342, d2040. doi:10.1136/bmj.d2040.
15. Boyjoo, Y., Pareek, V. K., & Liu, J. (2014). Synthesis of micro and nano-sized calcium carbonate particles and their applications. Journal of Materials Chemistry A, 2(35), 14270-14288. doi:10.1039/c4ta02070g.
16. Calcium Carbonates, Fine-Ground and Precipitated, Chemical Economics Handbook. (2018). Retrieved from https://ihsmarkit.com/products/fine-ground-and-precipitated-chemical-economics-handbook.html.
17. CCA-Europe, (2011). Calcium Carbonate Association. Retrieved from https://www.ima-europe.eu/about-ima-europe/associations/cca-europe.
18. Chae, M., Jang, J., & Park, K. (2019). Association between dietary calcium intake and the risk of cardiovascular disease among Korean adults. European journal of clinical nutrition, 1-8. doi:10.1038/s41430-019-0525-7.
19. Chen, J., & Xiang, L. (2009). Controllable synthesis of calcium carbonate polymorphs at different temperatures. Powder technology, 189(1), 64-69. doi:10.1016/j.powtec.2008.06.004.
20. Codex Alimentarius, (2019). Joint FAO/WHO Food Standards Programme Codex Committee on food additives or food additive groups. Retrieved from
http://www.fao.org/gsfaonline/additives/index.html?showSynonyms=1.
21. Commission Directive 2001/15/EC, (2001). on substances that may be added for specific nutritional purposes in foods for particular nutritional uses, Official Journal L 052 , P. 0019 – 0025.
22. Commission Regulation 2019/681/EU, (2019). on amending Annex II to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. Official Journal L 115/5, P. 59.
23. Commission Regulation 231/2012, (2012). on laying down specification for food additives listed in Annexes II and III to the regulation (EC) No 1333/2008 of the European Parliament of the Council. Official Journal L 83, p. 1–295.
24. Cosman, F., de Beur, S. J., LeBoff, M., Lewiecki, E., Tanner, B., Randall, S., & Lindsay, R. (2014). Clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis international, 25(10), 2359-2381. doi:10.1007/s00198-014-2794-2.
25. Council Directive 2002/46/EC, (2002). on the approximation of the laws of the Member States relating to food supplements. Official Journal, L 183, p. 51–57.
26. Council Directive 2006/52/EC, (2006). on food additives other than colours and sweeteners and Directive 94/35/EC on sweeteners for use in foodstuffs. Official Journal, L 204, p. 10–22.
27. Council Directive 94/36/EC, (1994). on colours for use in foodstuffs, Official Journal, L 237, p. 13–29.
28. Council Regulation 108/2008, (2008). on the addition of vitamins and minerals and of certain other substances to foods. Official Journal, L 39, p. 11–13.
29. Council Regulation 1907/2006, (2006). concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals, Official Journal, L 396, p.1.
30. d’Amora, M., Liendo, F., Deorsola, F. A., Bensaid, S., & Giordani, S. (2020). Toxicological profile of calcium carbonate nanoparticles for industrial applications. Colloids and Surfaces B: Biointerfaces, 110947. doi:10.1016/j.colsurfb.2020.110947.
31. Darwish, M. K., Abu El-Enin, A. S., & Mohammed, K. H. (2019). Formulation, optimization, and evaluation of raft-forming formulations containing Nizatidine. Drug development and industrial pharmacy, 45(4), 651-663. doi:10.1080/03639045.2019.1569033.
32. Dent, J., El-Serag, H., Wallander, M. A., & Johansson, S. (2005). Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut, 54(5), 710-717.
doi:10.1136/gut.2004.051821.
33. Dudefoi, W., Terrisse, H., Popa, A. F., Gautron, E., Humbert, B., & Ropers, M.-H. (2018). Evaluation of the content of TiO2 nanoparticles in the coatings of chewing gums. Food Additives & Contaminants: Part A, 35(2), 211-221. doi:10.1080/19440049.2017.1384576.
34. Duesberg, P., Li, R., Sachs, R., Fabarius, A., Upender, M. B., & Hehlmann, R. (2007). Cancer drug resistance: the central role of the karyotype. Drug Resistance Updates, 10(1-2), 51-58. doi:10.1016/j.drup.2007.02.003.
35. Eda Y, T. A., Yano Y. (2019). Effects of the toothpaste containing granule‑shaped cleaning agents on daily dental hygiene. J Jan Soc Dent Hygiene, 13, 32-42.
36. EFSA, (2011). EFSA Panel on Food Additives Nutrient Sources added to Food Scientific Opinion on re‐evaluation of calcium carbonate (E 170) as a food additive. EFSA Journal, 9(7), 2318. doi:10.2903/j.efsa.2011.2318.
37. Elbaz, N. M., Owen, A., Rannard, S., & McDonald, T. O. (2020). Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery. International journal of pharmaceutics, 574, 118866.
doi:10.1016/j.ijpharm.2019.118866.
38. Eloneva, S. (2010). Reduction of CO2 emissions by mineral carbonation: steelmaking slags as rawmaterial with a pure calcium carbonate end product. (PhD thesis). Aalto University, Helsinki.
39. Endoh M, T. A., Fuiiseki M, Eda Y, Itano M, Yano Y. (2019). Effects of Toothpaste containing granular calcium carbonate on oral health. Journal of International Oral Health, 11, 249-255.
40. Erdogan, N., & Eken, H. A. (2017). Precipitated calcium carbonate production, synthesis and properties. Physicochemical Problems of Mineral Processing, 53, 57-68.
doi:10.5277/ppmp170105. 599.
41. Erfanian, A., Rasti, B., & Manap, Y. (2017). Comparing the calcium bioavailability from two types of nano-sized enriched milk using in-vivo assay. Food chemistry, 214, 606-613.
doi:10.1016/j.foodchem.2016.07.116.
42. Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., . . . Bray, F. (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer, 136(5), E359-E386. doi:10.1002/ijc.29210.
43. Ferraro, P. M., Bargagli, M., Trinchieri, A., & Gambaro, G. (2020). Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian–Vegan Diets. Nutrients, 12(3), 779. doi:10.3390/nu12030779.
44. Gallocchio, F., Belluco, S., & Ricci, A. (2015). Nanotechnology and food: Brief overview of the current scenario. Procedia food science, 5, 85-88. doi:10.1016/j.profoo.2015.09.022.
45. Hagemeyer, R. (1983). “Pigment Coating,” in Pulp and Paper: Chemistry and Chemical Technology (J. Casey Ed. 3rd ed. Vol. 4). Newyork: John Wiley & Sons.
46. Hanzlik, R. P., Fowler, S. C., & Fisher, D. H. (2005). Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate. Journal of Pharmacology and Experimental Therapeutics, 313(3), 1217-1222. doi:10.1124/jpet.104.081893.
47. Hosokawa, M. N., K.; Naito, M.; Yokoyama, T. (2008). Nanoparticle Technology Handbook (1st ed.). Amsterdam, The Netherlands: Elsevier.
48. Huwald, E. (2001). Calcium carbonate-pigment and filler, calcium carbonate. Berlin: Springer.
49. Indu, S., Kumar, P., Rao, S., & Jayaram, H. (2019). Ayurvedic Perspective of Calcium Supplementation-A Review. . Vitam Miner, 8(3), 185-189.
50. Janve, M., & Singhal, R. S. (2018). Fortification of puffed rice extrudates and rice noodles with different calcium salts: Physicochemical properties and calcium bioaccessibility. LWT, 97, 67-75. doi:10.1016/j.lwt.2018.06.030.
51. Jayakumar, A., Padmini, H., Haritha, A., & Reddy, K. P. (2010). Role of dentifrice in plaque removal: a clinical trial. Indian Journal of Dental Research, 21(2), 213. doi:10.4103/0970-9290.66629.
52. JECFA, (2006). Compendium of Food Additive and Flavouring Agents Specifications. Retrieved from http://www.fao.org/ag/agn/jecfa-additives/details.html?id=75.
53. Katsube, T., Wajima, T., Fukuhara, T., & Kano, T. (2019). Effects of food and calcium carbonate on the pharmacokinetics of lusutrombopag, a novel thrombopoietin receptor agonist. Clinical therapeutics, 41(9), 1747-1754. e1742. doi:10.1016/j.clinthera.2019.06.004.
54. Kim, M.-K., Lee, J.-A., Jo, M.-R., Kim, M.-K., Kim, H.-M., Oh, J.-M., . . . Choi, S.-J. (2015). Cytotoxicity, uptake behaviors, and oral absorption of food grade calcium carbonate nanomaterials. Nanomaterials, 5(4), 1938-1954. doi:10.3390/nano5041938.
55. Knijnenburg, J. T., Posavec, L., & Teleki, A. (2019). Nanostructured minerals and vitamins for food fortification and food supplementation. In Nanomaterials for Food Applications (pp. 63-98): Elsevier.
56. Kumssa, D. B., Joy, E. J., Ander, E. L., Watts, M. J., Young, S. D., Walker, S., & Broadley, M. R. (2015). Dietary calcium and zinc deficiency risks are decreasing but remain prevalent. Scientific reports, 5, 10974. doi:10.1038/srep10974.
57. Lailiyah Q., B., M., and Darminto, D. . (2012). Effect of temperature and flow rate of CO2 gas on synthesis of calcium carbonate precipitate by bubbling method. Journal of Science and Arts ITS, 1(69), 6-10. doi:10.12962/j23373520.v1i1.287.
58. Li, L., Yang, Y., Lv, Y., Yin, P., & Lei, T. (2020). Porous calcite CaCO3 microspheres: Preparation, characterization and release behavior as doxorubicin carrier. Colloids and Surfaces B: Biointerfaces, 186, 110720. doi:10.1016/j.colsurfb.2019.110720.
59. Long, Y., Song, K., York, D., Zhang, Z., & Preece, J. A. (2013). Engineering the mechanical and physical properties of organic–inorganic composite microcapsules. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 433, 30-36. doi:10.1016/j.colsurfa.2013.04.055.
60. Mallya, P. L., Acharya, S., Ballal, V., Ginjupalli, K., Kundabala, M., & Thomas, M. (2013). Profilometric study to compare the effectiveness of various finishing and polishing techniques on different restorative glass ionomer cements. Journal of Interdisciplinary Dentistry, 3(2), 86. doi:10.4103/2229-5194.126867.
61. Mantilaka, M., Pitawala, H., Rajapakse, R., Karunaratne, D., & Wijayantha, K. U. (2014). Formation of hollow bone-like morphology of calcium carbonate on surfactant/polymer templates. Journal of crystal growth, 392, 52-59. doi:10.1016/j.jcrysgro.2014.02.007.
62. Matei, C., Berger, D., Dumbrava, A., Radu, M. D., & Gheorghe, E. (2020). Calcium carbonate as silver carrier in composite materials obtained in green seaweed extract with topical applications. Journal of Sol-Gel Science and Technology, 93(2), 315-323. doi:10.1007/s10971-019-05145-6.
63. Medicines. M.H.R.A. Healthcare products Regulatory Agency (2015). UK Public Assessment Report for Adcal-D3 Caplets, 750 mg/200 I.U., film-coated tablets (calcium carbonate, vitamin D3) PL16508/0039.
64. Moyer, V. A. (2013). Vitamin D and calcium supplementation to prevent fractures in adults: US Preventive Services Task Force recommendation statement. Annals of internal medicine, 158(9), 691-696. doi:10.7326/0003-4819-158-9-201305070-00603.
65. Nicholson, K. J., Smith, K. J., McCoy, K. L., Carty, S. E., & Yip, L. (2020). A comparative cost-utility analysis of postoperative calcium supplementation strategies used in the current management of hypocalcemia. Surgery, 167(1), 137-143. doi:10.1016/j.surg.2019.05.077.
66. Nishigawa, M., Nishi, K., Kawano, R., Yamamoto, K., Kobayashi, Y., Yuka, H., & Watanabe, T. (1992). Plaque removal effect of the dentifrice containing granulated zeolite. JOURNAL OF DENTAL HEALTH, 42(5), 682-688. doi:10.5834/jdh.42.682..
67. Paraskevas, S., Rosema, N., Versteeg, P., Timmerman, M. F., Van der Velden, U., & Van der Weijden, G. (2007). The additional effect of a dentifrice on the instant efficacy of toothbrushing: a crossover study. Journal of periodontology, 78(6), 1011-1016. doi:10.1902/jop.2007.060339.
68. Peters, R. J., Bouwmeester, H., Gottardo, S., Amenta, V., Arena, M., Brandhoff, P., . . . Pesudo, L. Q. (2016). Nanomaterials for products and application in agriculture, feed and food. Trends in Food Science & Technology, 54, 155-164. doi:10.1016/j.tifs.2016.06.008.
69. Prentice, R., Pettinger, M., Jackson, R., Wactawski-Wende, J., Lacroix, A., Anderson, G., . . . Vitolins, M. (2013). Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study. Osteoporosis international, 24(2), 567-580. doi:10.1007/s00198-012-2224-2.
70. Rahardjo, A., Gracia, E., Riska, G., Adiatman, M., & Maharani, D. A. (2015). Potential side effects of whitening toothpaste on enamel roughness and micro hardness. Int J Clin Prev Dent, 11(4), 239-242. doi:10.15236/ijcpd.2015.11.4.239.
71. Reginster, J.-Y., & Burlet, N. (2006). Osteoporosis: a still increasing prevalence. Bone, 38(2), 4-9. doi:10.1016/j.bone.2005.11.024.
72. Reid, I. R., & Bolland, M. J. (2012). Calcium supplements: bad for the heart? In: BMJ Publishing Group Ltd and British Cardiovascular Society.
73. Riggs, B. L., & Melton Iii, L. (1995). The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone, 17(5), S505-S511. doi:10.1016/8756-3282(95)00258-4.
74. Roark, R., Sydor, M., Chatila, A. T., Umar, S., De La Guerra, R., Bilal, M., & Guturu, P. (2020). Management of gastroesophageal reflux disease. Disease-a-Month, 66(1), 100849. doi:10.1016/j.disamonth.2019.02.002.
75. Roskill, (2005). The Economics of Precipitated Calcium Carbonate: Roskill Reports on Metals and Minerals, 6th ed., Roskill Informatics Services Ltd., ISBN 978 0 86214 509 5, London, UK.
76. Roskill. (2012). "Ground and Precipitated Calcium Carbonate: Global Industry Market and Outlook". Retrieved from http://www.roskill.com/reports/industrial-minerals/ground-and-precipitated-calcium-carbonate-1.
77. Saveleva, M., Ivanov, A., Kurtukova, M., Atkin, V., Ivanova, A., Lyubun, G., . . . Fedonnikov, A. (2018). Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules: Synthesis, loading and in vivo applications. Materials Science and Engineering: C, 85, 57-67. doi:10.1016/j.msec.2017.12.019.
78. Senchukova, M., Tomchuk, O., Shurygina, E., Letuta, S., Alidzhanov, E., Nikiyan, H., & Razdobreev, D. (2019). Calcium Carbonate Nanoparticles Can Activate the Epithelial–Mesenchymal Transition in an Experimental Gastric Cancer Model. Biomedicines, 7(1), 21. doi:10.3390/biomedicines7010021.
79. Seo, K.-S., Han, C., Wee, J.-H., Park, J.-K., & Ahn, J.-W. (2005). Synthesis of calcium carbonate in a pure ethanol and aqueous ethanol solution as the solvent. Journal of crystal growth, 276(3-4), 680-687. doi:10.1016/j.jcrysgro.2004.11.416.
80. Shete, R. B., Muniswamy, V. J., Pandit, A. P., & Khandelwal, K. R. (2015). Formulation of eco-friendly medicated chewing gum to prevent motion sickness. AAPS PharmSciTech, 16(5), 1041-1050. doi:10.1208/s12249-015-0296-y.
81. Sontag, S. (1990). The medical management of reflux esophagitis. Role of antacids and acid inhibition. Gastroenterology Clinics of North America, 19(3), 683-712..
82. Stark, W. J., Stoessel, P. R., Wohlleben, W., & Hafner, A. (2015). Industrial applications of nanoparticles. Chemical Society Reviews, 44(16), 5793-5805. doi:10.1039/c4cs00362d.
83. Taylor, C., Yaktine, A., & Del Valle, H. (2011). Institute of Medicine (US) committee to review dietary reference intakes for vitamin D and calcium. In Overview of vitamin D.
84. Thélin, C. S., & Richter, J. E. (2020). the management of heartburn during pregnancy and lactation. Alimentary Pharmacology & Therapeutics, 51(4), 421-434. doi:10.1111/apt.15611.
85. Thenepalli, T., Jun, A. Y., Han, C., Ramakrishna, C., & Ahn, J. W. (2015). A strategy of precipitated calcium carbonate (CaCO3) fillers for enhancing the mechanical properties of polypropylene polymers. Korean Journal of Chemical Engineering, 32(6), 1009-1022. doi:10.1007/s11814-015-0057-3.
86. Guo, Y., Wang, F., Zhang, J., Yang, L., Shi, X., Fang, Q., & Ma, X. (2013). Biomimetic synthesis of calcium carbonate with different morphologies under the direction of different amino acids. Research on Chemical Intermediates, 39(6), 2407-2415. doi:10.1007/s11164-012-0767-7.
87. Torne, S., Sheela, A., & Sarada, N. (2020). Investigation of the Role of the Alkalizing Agent in Sodium Alginate Liquid Anti-reflux Suspension. Current Drug Therapy, 15(1), 53-60. doi:10.2174/1574885514666190103140951.
88. Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015). Global cancer statistics, 2012. CA: a cancer journal for clinicians, 65(2), 87-108.
doi:10.3322/caac.21262.
89. Trailokya, A., Srivastava, A., Bhole, M., & Zalte, N. (2017). Calcium and calcium salts. Journal of The Association of Physicians of India, 65(2), 100-103.
90. US Food and Drug Administration, (2017). Rules and Regulations, Department of Health and Human Services, 21 CFR Part 73, Docket No. FDA–2016–C–2767.
91. Valkenburg, C., Slot, D. E., Bakker, E. W., & Van der Weijden, F. A. (2016). Does dentifrice use help to remove plaque? A systematic review. Journal of clinical periodontology, 43(12), 1050-1058. doi:10.1111/jcpe.12615.
92. Vance, M. E., Kuiken, T., Vejerano, E. P., McGinnis, S. P., Hochella Jr, M. F., Rejeski, D., & Hull, M. S. (2015). Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory. Beilstein journal of nanotechnology, 6(1), 1769-1780.
doi:10.3762/bjnano.6.181.
93. Vidallon, M. L. P., Douek, A. M., Quek, A., McLiesh, H., Kaslin, J., Tabor, R. F., . . . Teo, B. M. (2020). Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging. Particle & Particle Systems Characterization, 37(2), 1900471. doi:10.1002/ppsc.201900471.
94. Waheed, M., Butt, M. S., Shehzad, A., Adzahan, N. M., Shabbir, M. A., Suleria, H. A. R., & Aadil, R. M. (2019). Eggshell calcium: A cheap alternative to expensive supplements. Trends in Food Science & Technology, 91, 219-230. doi:10.1016/j.tifs.2019.07.021.
95. Wang, C., Li, Z., Cao, D., Zhao, Y. L., Gaines, J. W., Bozdemir, O. A., . . . Zink, J. I. (2012). Stimulated release of size‐selected cargos in succession from mesoporous silica nanoparticles. Angewandte Chemie International Edition, 51(22), 5460-5465. doi:10.1002/anie.201107960.
96. Wei, S., Gao, J., Zhang, M., Dou, Z., Li, W., & Zhao, L. (2020). Dual delivery nanoscale device for miR-451 and adriamycin co-delivery to combat multidrug resistant in bladder cancer. Biomedicine & Pharmacotherapy, 122, 109473. doi:10.1016/j.biopha.2019.109473.
97. Wiley, D., & Nee, C. N. Y. (2020). Food ingredients. In Food and Society (pp. 377-391): Elsevier.
98. Xing, J., Cai, Y., Wang, Y., Zheng, H., & Liu, Y. (2020). Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release. Advances in Polymer Technology, 2020. doi:10.1155/2020/8749238.
99. Yamagishi, A., Yoshida, H., Maeda, K., Tsujita, S., Eguchi Y. (1990). Research for plaque on the interproximal surface. JOURNAL OF DENTAL HEALTH, 40(4), 506-507.
100. Zhao, D., Liu, C.-J., Zhuo, R.-X., & Cheng, S.-X. (2012). Alginate/CaCO3 hybrid nanoparticles for efficient codelivery of antitumor gene and drug. Molecular pharmaceutics, 9(10), 2887-2893. doi:10.1021/mp3002123.
101. Zhao, Y., Lu, Y., Hu, Y., Li, J. P., Dong, L., Lin, L. N., & Yu, S. H. (2010). Synthesis of superparamagnetic CaCO3 mesocrystals for multistage delivery in cancer therapy. Small, 6(21), 2436-2442. doi:10.1002/smll.201000903.
102. Zhu, B., He, H., Guo, D., Zhao, M., & Hou, T. (2020). Two novel calcium delivery systems fabricated by casein phosphopeptides and chitosan oligosaccharides: Preparation, characterization, and bioactive studies. Food Hydrocolloids, 102, 105567.
doi:10.1016/j.foodhyd.2019.105567.
103. Zhu, D., Wen, H.-M., Li, W., Cui, X.-B., Ma, L., & Kang, A. (2014). pH-responsive drug release from porous zinc sulfide nanospheres based on coordination bonding. RSC Advances, 4(63), 33391-33398. doi:10.1039/c4ra05277c.