FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FLURBIPROFEN UTILIZING VARIOUS SUPERDISINTEGRANTS

Abstract

This study aimed to develop mouth dissolving tablets of Flurbiprofen, a non-selective COX inhibitor commonly used to treat rheumatoid arthritis and osteoarthritis. The objective was to improve patient compliance by providing a convenient dosage form, particularly for pediatric and geriatric patients or those who have difficulty swallowing conventional tablets or capsules. Different formulations of oral dispersible tablets of Flurbiprofen were prepared using various superdisintegrants (sodium starch glycolate, crospovidone, croscarmellose sodium, and L-hydroxy propyl cellulose) through the direct compression method. The tablets underwent thorough evaluation for hardness, thickness, friability, weight variation, uniformity of content, wetting time, disintegration time, and dissolution behavior. In vitro dissolution studies revealed that the release rate followed the order of superdisintegrants: croscarmellose sodium > crospovidone > L-hydroxy propyl cellulose > sodium starch glycolate. Among the formulations, FF-11, containing 6% croscarmellose sodium, exhibited the highest in vitro dissolution. Based on these findings, it was concluded that croscarmellose sodium at a concentration of 6% is suitable for the preparation of immediate-release mouth dissolving tablets of Flurbiprofen.