MANAGEMENT OF PERIOPERATIVE PAIN IN ANTERIOR CRUCIATE LIGAMENT SURGERY PATIENTS RECEIVING OXYCODONE, GABAPENTIN, NSAID AND PLACEBO: CLINICAL TRIAL STUDY
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Keywords
Perioperative pain, Anterior Cruciate Ligament Surgery, oxycodone, Gabapentin. NSAIDs, Placebo, Postoperative pain
Abstract
Anterior cruciate ligament reconstructions (ACLR) are a common orthopedic sports medicine procedure, with around 130,000 arthroscopic cases annually, mostly performed on an outpatient basis. While ACLR boasts success rates of up to 95%, postoperative pain remains a significant obstacle to timely patient discharge, leading to prolonged care and increased costs. Despite its prevalence and high success rates, there is a lack of consensus and clear protocols regarding the most effective perioperative pain management strategies. This parallel clinical trial involved 200 participants undergoing ACL surgery, randomly assigned to receive placebo, oxycodone, gabapentin, or NSAIDs one hour prior to surgery. Pain levels were assessed using the Visual Analog Scale (VAS) at various post-operative time intervals, and pethidine usage was recorded. Findings indicated gender-based discrepancies in post-operative pain, with females experiencing higher intensity, particularly at three and 6hours post-surgery. Oxycodone demonstrated superior immediate relief, while placebo recipients were more likely to seek additional pain relief, indicating perceived ineffectiveness. The study emphasizes the evolving nature of post-operative pain and underscores the necessity for effective long-term pain management strategies, offering significant insights for optimizing pain relief approaches in ACL surgery patients
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Ramin Abrishami
Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran
Seyed Hadi Aghili
Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran.
Cyrus Afshar
Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran
Mehri Farhang Ranjbar
Neuroscience Lab, Anatomy and Cell Biology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ibrahim Mohammadzadeh
Neuroscience Lab, Anatomy and Cell Biology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Farzin Dehghani Mahmoodabadi
Shahid Beheshti University of Medical Science, Tehran, Iran