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Dr. V. Vijaya Lakshmi
Dr. V. Madhu Priya
Dr. E. Lokeswara Reddy
Dr. G. Sarada


Pre-oxygenation, Peripheral Oxygen Saturation, Elective Surgeries, General Anesthesia


Background: In this study, we wanted to study the comparison of the effects of different periods of pre-oxygenation on peripheral oxygen saturation (SpO2), to find out the optimal duration of pre-oxygenation.

 Methods: This was a prospective, randomised, double-blind, controlled study that was carried out over a period of one-year in the Department of Anesthesiology and Critical Care Medicine at ACSRGMC, Nellore, involving 75 ASA I and 2 physical status patients who were posted for elective surgeries. The patients were in the age range of 20 to 50 years. The study was approved by the institutional ethics committee, and the participant’s gave written informed consent.

 Results: All of the GROUPs had similar demographics. The mean SpO2 levels after one minute of apnoea were 97.44±2.95 in GROUP A, 98.20±2.59 in GROUP B, and 99.96 ± 0.20in GROUP C, comparable between GROUPs A, B but revealed a significant difference between GROUPs A and B. The difference in SPO2 between GROUP B, C and GROUP A, C suggests that the drop in saturation in GROUP A, B was significant compared to GROUP C. The mean PR in GROUP A was 107.16 ±10.71, which was significantly higher than the mean pulse rates in GROUP B, C which were 101.04 ± 7.55and 99.24 ± 9.02, respectively and, GROUP B, C scores were substantially closer to baseline levels. Based on our findings, pre oxygenation for five minutes protects against saturation drops better than pre oxygenation for three minutes or 1 minute.

 Conclusion: The best way to pre-oxygenate is to use the Magill circuit and tidal volume breathing technique for five minutes. Moreover, pre-oxygenation significantly postpones by three and a half minutes the commencement of apnea-induced decrease in peripheral oxygen saturation during tidal volume breathing.

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