THE ASSOCIATION BETWEEN ARTERIAL STIFFNESS AND OBESITY IN YOUNG ADULTS: A CASE CONTROL STUDY

Main Article Content

Dr. Ayesha Mustafa
Tabassam Zia
Shagufta Tasneem
Khadija Tul Kubra
Mawa Latif

Keywords

Arterial Stiffness, Obesity, Young Adults, BMI

Abstract

Background: The world is concerned about the rapid increase in overweight and obesity prevalence and the rising burden of disease, particularly in developing nations like Pakistan.


Objective: The objective of the current study was to find out the he levels of arterial stiffness among obese subject and healthy subjects.


Material and Methods: A total of 80 participants were included with age groups between 18-30 years and participants were divided into two groups. The group I-obese (n=40) and group II non-obese (n=40). Arterial stiffness was investigated by pulse wave velocity (Brachial ankle pulse wave velocity) and Augmentation index (ALX).


Results: Pulse wave velocity and Augmentation Index shows significantly positive correlation with BMI.


Conclusion: The increase in arterial stiffness was closely correlated to the body mass index, which indicating that adult obesity has an adverse impact on vascular adaptation.

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References

1. WHO (2020) Obesity. World Health Organization.
2. Ranjani H, Mehreen TS, Pradeepa R, Anjana RM, Garg R, et al. (2016) Epidemiology of childhood overweight & obesity in India: A systematic review. Indian J Med Res 143(2): 160-174.
3. WHO (2020) Overweight and obesity. World Health Organization.
4. Luhar S, Timæus IM, Jones R, Cunningham S, Patel SA, et al. (2020) Forecasting the prevalence of overweight and obesity in India to 2040. PLoS ONE 15(2): e0229438.
5. Akil L, Ahmad HA (2011) Relationships between obesity and cardiovascular diseases in four southern states and Colorado. J Health Care Poor Underserved 22(S4): 61-72.
6. V. Z. Rocha and P. Libby (2009) “Obesity, inflammation, and atherosclerosis,” Nature Reviews Cardiology, vol. 6, no. 6, pp. 399–409.
7. R. Ross (1999) “Atherosclerosis–an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126.
8. Han JC, Lawlor DA, Kimm SY (2010) Childhood obesity. Lancet. 2010; 375:1737-1748.
9. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents (2011); National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics. 2011; 128(suppl 5):S213-S256.
10. Cote AT, Harris KC, Panagiotopoulos C, Sandor GG, Devlin AM (2013) Childhood obesity and cardiovascular dysfunction. J Am Coll Cardiol. 62:1309-1319.
11. Mozos I, Malainer C, Horbańczuk J, et al (2017) Inflammatory markers for arterial stiffness in cardiovascular diseases. Front Immunol. 8:1058.
12. Zieman SJ, Melenovsky V, Kass DA (2005) Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 25:932-943.
13. Ochi M, Kohara K, Tabara Y et al (2010) Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men. Atherosclerosis; 212: 327–332.
14. Abbatecola AM, Chiodini P, Gallo C et al (2012) Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age (Dordrecht, Netherlands); 34: 469–478.
15. Sherwood, L. (2008). Human Physiology: From Cells to Systems. Boston: Cengage Learning.
16. Sakuma K, Yamaguchi A (2013) Sarcopenic obesity and endocrinal adaptations with age. Int J Endocrinol; 2013: 1–12. Available from: http://dx.doi.org/10.1155/ 2013/204164.