INVESTIGATION OF CHEMICAL COMPOSITION AND THERAPEUTIC POTENTIAL OF CAESALPINIA CRISTA POWDER IN DIABETIC MALE PATIENTS

Abstract

Around 60% of the world's population uses traditional medicines derived from medicinal plants. Diabetes is a metabolic disorder that manifests as either a lack of insulin production by pancreatic beta cells or a failure of the body to properly use the insulin that is generated. Fever nut is an herb that has been used in herbal treatments for many years to manage a range of diseases due to its antioxidants, phytochemical, saponin, and polyphenol content The present study was carried out to investigate the chemical composition and therapeutic potential of Caesalpinia crista powder in diabetic male patients. Physicochemical screening, including proximate profile, minerals, and antioxidant potential, was also investigated for this purpose. The percentages of fat, protein, and fibre in fever nut (Caesalpinia Crista) were found to be 29.3%, 9.5%, and 3.6%, respectively. The DPPH and FRAP levels were found to be 102.3112.06 and 56.3411.27, respectively. Furthermore, the anti-diabetic effects of fever nut powder were evaluated on human male subject. Male Diabetic Patients were divided into three equal groups based on inclusion and exclusion criteria. One group was considered control group G₀ given no treatment and the other two groups were considered as treatment groups G₁ and G₂ received 500mg/day and 1000mg /daycapsules of Caesalpinia crista powder orally every day for the duration of 2 months. After each week, both treatment groups G₁ and G₂ had minute significant reductions in fasting blood glucose levels and random blood glucose levels. After two months, the overall decline in the G₁ group was from 196.50±10.32 to 195.01±9.05 in fasting blood glucose levels and from 197.989±.24 to 197.031±5.21 in random glucose levels. At the end of the study, the fasting blood glucose level in G2 was reduced from 194.11±10.67 to 192.01±8.03, and the random blood glucose level was reduced from 219.96a11.01 to 218.01b15.02. HBA1C levels reduced considerably in treatment groups G₁ and G₂, with values lowering from 9.57±1.95 to 9.512±.04 in G₁ and from 10.85±1.95 to 9.851.70 in± G₂. According to the findings of this study, Caesalpinia crista has a significant amount of antioxidants and polyphenols both of which have therapeutic potential and can be used to treat and control diabetes mellitus.