TO DEDUCE THE CHANGES IN LIPID PROFILE AND BMI, THAT LEADS TO CARDIOVASCULAR DISEASES IN POSTMENOPAUSAL WOMEN

Main Article Content

Kiran Lohana
Jai Parkash
Muhammad Zain Shaikh
Mubashir Ghani
Naina lohana
Dr Arsalan Ahmed Uqaili

Keywords

Cardiovascular diseases, menopause, risk factor, women

Abstract

Aim: The present observation, case report study was conducted during the period of one year in Hyderabad to observe the changes in the lipid profile of postmenopausal women that make them vulnerable to cardiovascular diseases.


Materials and Methods: Venous blood samples of 320 postmenopausal women were taken to see changes in lipid profile. Lifestyle and food habits were noted by filling out the questionnaire. Women with diagnosed cardiovascular diseases, on hormone replacement therapy or lipid-lowering drugs, were excluded from the study.


Results: Weight, BMI, and stature ranged greatly between groups. Body changes after menopause; overweight women had higher weight, BMI, and height than normal women. Both normal-weight and overweight postmenopausal women had considerable lipid changes. Postmenopausal women of normal weight had lower HDL cholesterol, higher LDL cholesterol, and increased total cholesterol and triglycerides. VLDL levels did not decrease (p > 0.05), but other lipid fractions did, suggesting cardiovascular risk in this cohort.


Conclusion: Studies show that unfavorable lipid alterations at this age increase cardiovascular disease risk. Postmenopausal women must regulate lipids to reduce risk and improve cardiovascular health.

Abstract 98 | pdf Downloads 36

References

1. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
2. https://ourworldindata.org/grapher/cardiovascular-disease-death-rates?tab=chart&country=PAK. Available from:
https://ourworldindata.org/grapher/cardiovascular-disease-death-rates?tab=chart&country=PAK
3. https://www.aku.edu/news/Pages/News_Details.aspx?nid=NEWS-002437. Available from: https://www.aku.edu/news/Pages/News_Details.aspx?nid=NEWS-002437
4. Pardhe BD, Ghimire S, Shakya J, Pathak S, Shakya S, Bhetwal A, et al. Elevated Cardiovascular Risks among Postmenopausal Women: A Community Based Case Control Study from Nepal. Biochem Res Int [Internet]. 2017;2017:1–5. Available from:
https://www.hindawi.com/journals/bri/2017/3824903/
5. Harrison-Bernard LM, Raij L. Postmenopausal hypertension. Curr Hypertens Rep. 2000 Mar;2(2):202–7.
6. Tandon VR, Mahajan A, Sharma S, Sharma A. Prevalence of cardiovascular risk factors in postmenopausal women: A rural study. J Midlife Health. 2010 Jan;1(1):26–9.
7. Kumar S, Shah C, Oommen ER. Study of cardiovascular risk factors In pre and postmenopausal women. Int J Pharma Sci Res. 2012;3(12):560–70.
8. Schulze PC, Drosatos K, Goldberg IJ. Lipid Use and Misuse by the Heart. Circ Res [Internet]. 2016 May 27;118(11):1736–51. Available from:
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.306842
9. . CAOU, . CCA, . INU, . ACN. Lipid Profile of Postmenopausal Women in Calabar, Nigeria. Pakistan Journal of Nutrition [Internet]. 2005 Dec 15;5(1):79–82. Available from: https://www.scialert.net/abstract/?doi=pjn.2006.79.82
10. Lippi G, Plebani M. Statins for Primary Prevention of Cardiovascular Disease. Trends Pharmacol Sci [Internet]. 2017 Feb;38(2):111–2. Available from:
https://linkinghub.elsevier.com/retrieve/pii/S0165614716301821
11. Currie H, Williams C. Menopause, Cholesterol and Cardiovascular Disease. US Cardiology Review [Internet]. 2008 May 1;5(1):12–4. Available from:
https://www.uscjournal.com/articles/Menopause-cholesterol-cardiovascular-disease
12. Wadhera RK, Steen DL, Khan I, Giugliano RP, Foody JM. A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality. J Clin Lipidol [Internet]. 2016 May;10(3):472–89. Available from:
https://linkinghub.elsevier.com/retrieve/pii/S1933287415004493
13. Godsland IF. Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000. Fertil Steril. 2001 May;75(5):898–915.
14. Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, et al. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol [Internet]. 2015 Jul;3(7):507–13. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2213858715001266
15. Mayoclinic. Triglycerides level [Internet]. Available from:
https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/triglycerides/art-20048186#:~:text=Normal — Less than 150 milligrams,5.7 mmol%2FL or above)
16. Rabkin SW, Mathewson FAL, Hsu PH. Relation of body weight to development of ischemic heart disease in a cohort of young north American men after a 26 year observation period: The manitoba study. Am J Cardiol [Internet]. 1977;39(3):452–8. Available from:
https://linkinghub.elsevier.com/retrieve/pii/S0002914977801045
17. Khan SS, Ning H, Wilkins JT, Allen N, Carnethon M, Berry JD, et al. Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity. JAMA Cardiol [Internet]. 2018 Apr 1;3(4):280. Available from:
http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2018.0022
18. Zubair F, Nawaz SK, Nawaz A, Nangyal H, Amjad N, Khan MS. Prevalence of cardiovascular diseases in Punjab, Pakistan: a cross-sectional study. J Public Health (Bangkok) [Internet]. 2018 Oct 31;26(5):523–9. Available from: http://link.springer.com/10.1007/s10389-018-0898-4
19. Jafar TH, Jafary FH, Jessani S, Chaturvedi N. Heart disease epidemic in Pakistan: Women and men at equal risk. Am Heart J [Internet]. 2005 Aug;150(2):221–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S000287030400657X