VITAMIN D SUPPLEMENTATION IN DRY EYE DISEASE: A SYSTEMATIC REVIEW
Main Article Content
Keywords
dry eye disease, ophthalmology, vitamin D, treatment, eye disease
Abstract
Background: Dry eye disease (DED) is a multifactorial ocular condition characterized by a disruption in the tear film. This review aims to elucidate the potential mechanisms underlying the relationship between Vitamin D and DED, evaluate the consistency of findings across diverse studies, and identify areas for future research and clinical applications.
Methods: A systematic review was performed by searching relevant studies until November 2023 using the PubMed, MEDLINE, and EMBASE databases. Studies involving individuals with DED and has vitamin D supplementation were included in this review.
Results: The systematic literature search identified 12 studies meeting the inclusion criteria, covering various aspects of vitamin D and DED. The results of this systematic review shed light on the diverse aspects of vitamin D supplementation in the context of DED. By synthesizing findings from selected studies, the review examines the influence of vitamin D on DED symptomatology, clinical outcomes, and relevant biochemical markers. The results contribute to a nuanced understanding of the potential benefits or limitations of vitamin D supplementation in the management of DED. Detailed analysis of the selected studies offers valuable insights into the current state of knowledge and highlights areas that warrant further investigation.
Conclusion: In conclusion, this systematic review provides a comprehensive overview of the existing literature on vitamin D supplementation and its relevance to dry eye disease. The findings collectively suggest that vitamin D supplementation holds potential as a therapeutic intervention for DED, impacting symptoms, clinical outcomes, and associated biochemical markers. However, further research is warranted to elucidate optimal dosage, duration, and specific patient populations that may benefit most from this intervention.
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Muhammad Nur Agung Mappatanga
Department of Opthalmology, Faculty of Medicine, Hasanuddin University, Hasanuddin University Hospital, Makassar, Indonesia
Junaedi Sirajuddin
Department of Opthalmology, Faculty of Medicine, Hasanuddin University, Hasanuddin University Hospital, Makassar, Indonesia
Hasnah Eka
Department of Opthalmology, Faculty of Medicine, Hasanuddin University, Hasanuddin University Hospital, Makassar, Indonesia