HIGHER PREVALENCE OF ESBL PRODUCING ACINETOBACTER SPECIES AT ROHILKHAND REGION IN U.P.

Main Article Content

Dr Ved Prakash Sharma
Nigar Fatima
Dr Vashishth Mishra
Dr Rajesh Bareja

Keywords

Increased Prevalence, ESBL, Acinetobacter Species and Double Disc Synergy Test

Abstract

Introduction: Acinetobacter is an opportunistic pathogen that has evolved into important bacteria associated with nosocomial infections worldwide and is known to develop multidrug resistance (MDR), extensive drug resistance (XDR) and pan drug strains resistance (PDR) including the carbapenem group.


Methods: This study was a hospital cross-sectional study conducted at the Department of Microbiology, Rohilkhand Medical College Bareilly Utter Pradesh on 350 specimens of Acinetobacter species. All clinical specimens of Acinetobacter species were obtained from the microbiology laboratory of Rohilkhand medical college Bareilly. Antimicrobial susceptibility tests (AST) were performed according to the disk diffusion method of scientist Kirby Bauer and based on CLSI guidelines. Extended-spectrum β-lactamase (ESBL)-producing Acinetobacter species were identified using DDST.


Results: Out of 350 samples, 88% of the samples showed resistance to ceftazidime, 78.6% to cefepime and 89.7% to ceftriaxone. Of these, 53% of Acinetobacter isolates were phenotypically found to be ESBL producers.


Conclusion: This current study concluded an alarming level of ESBL producing Acinetobacter spp. in various clinical specimens in the Rohilkhand region. Prevalence of ESBL producing Acinetobacter spp. increasingly threatens health care settings and clinical patient outcomes worldwide and points to the overuse of antibiotics. Detection of an ESBL producer requires active surveillance. This will help prevent the spread of infection.

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