PATIENT-CENTERED OUTCOMES OF THERAPEUTIC STRATEGIES IN TREATMENT OF CHRONIC ULCERS

Main Article Content

Iqra Suleman
Dr. Momina Tuz Zobia Malik
Dr. Syeda Shehar Bano
Dr. Atiqa Ali
Mehwish Idrees
Dr. Ayesha Iqbal Shehzad

Keywords

chronic ulcers, dressings, compression cure, biological skin substitutes.

Abstract

Background: Chronic ulcers pose significant challenges in dermatological therapy. Understanding the etiology of these ulcers is pivotal for effective treatment. Local therapy is often indispensable, focusing on cleaning, debridement, infection control, and the application of various topical agents, including medications and dressings.


Methods: This review explores recent therapeutic advancements for chronic ulcers, considering both established and emerging approaches.


Results: A growing area of research focuses on the development and application of biological skin substitutes. These substitutes offer potential solutions for enhancing wound healing and tissue regeneration. Investigations into the role of growth factors in ulcer healing have shown promise. Identifying the most effective growth factors and methods for their delivery is essential to optimize treatment outcomes. Laser therapy is gaining attention as a viable option for ulcer management. Researchers are exploring the mechanisms and safety considerations associated with laser treatments for chronic ulcers. Hyperbaric oxygen therapy's potential to expedite wound healing is under scrutiny. Determining optimal treatment protocols and understanding its influence on tissue regeneration are key areas of focus. Electrical stimulation has emerged as a potential adjunctive treatment for chronic ulcers. Investigating the mechanisms by which electrical stimulation promotes healing and its parameters for effective application is a critical research area. The use of negative pressure wound therapy is showing promise in ulcer management. Research efforts are directed towards understanding its mechanisms and identifying patient populations that benefit most from this therapy.


Cost-Effectiveness Analysis: Evaluating the economic viability and accessibility of novel therapeutic strategies compared to traditional approaches is a vital component of current research. Patient-Centered Outcomes: Studies are assessing the impact of various ulcer treatments on patient quality of life, pain management, and overall well-being, considering patient-reported outcomes. Combination Therapies: Investigating the synergistic effects of combining multiple therapeutic strategies, such as growth factors with electrical stimulation or biological skin substitutes with hyperbaric oxygen therapy, is a significant area of inquiry.


Conclusion: This comprehensive review of therapeutic advances in chronic ulcer management highlights the significance of ongoing research to improve treatment efficacy, patient outcomes, and the accessibility of innovative approaches. It also underscores the enduring value of traditional therapies.

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References

1. Carter, M. J., et al. (2023). "Chronic wound prevalence and the associated cost of treatment in Medicare beneficiaries: changes between 2014 and 2019." Journal of Medical Economics 26(1): 894-901.
2. Carter, M. J., et al. (2023). "Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis." Advances in Wound Care 12(4): 177-186.
3. Herruzo, R., et al. (2023). "Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers." Wound Repair and Regeneration 31(3): 401-409.
4. Holubová, A., et al. (2023). "The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study." Antibiotics 12(9): 1364.
5. Li, S., et al. (2023). "The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of Personalized Medicine 13(3): 430.
6. Rayate, A. S., et al. (2023). "Current scenario of traditional medicines in management of diabetic foot ulcers: A review." World Journal of Diabetes 14(1): 1.
7. Saboia-Dantas, C. J., et al. (2023). "Progressive Platelet Rich Fibrin tissue regeneration matrix: Description of a novel, low cost and effective method for the treatment of chronic diabetic ulcers—Pilot study." Plos one 18(5): e0284701.
8. Shapira, E., et al. (2023). "The efficacy of combined ultrasound and electric field stimulation therapy in the treatment of venous leg ulcers." Scars, Burns & Healing 9: 20595131231174225.
9. Carter, M. J., et al. (2023). "Chronic wound prevalence and the associated cost of treatment in Medicare beneficiaries: changes between 2014 and 2019." Journal of Medical Economics 26(1): 894-901.
10. Carter, M. J., et al. (2023). "Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis." Advances in Wound Care 12(4): 177-186.
11. Herruzo, R., et al. (2023). "Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers." Wound Repair and Regeneration 31(3): 401-409.
12. Holubová, A., et al. (2023). "The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study." Antibiotics 12(9): 1364.
13. Li, S., et al. (2023). "The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of Personalized Medicine 13(3): 430.
14. Rayate, A. S., et al. (2023). "Current scenario of traditional medicines in management of diabetic foot ulcers: A review." World Journal of Diabetes 14(1): 1.
15. Saboia-Dantas, C. J., et al. (2023). "Progressive Platelet Rich Fibrin tissue regeneration matrix: Description of a novel, low cost and effective method for the treatment of chronic diabetic ulcers—Pilot study." Plos one 18(5): e0284701.
16. Shapira, E., et al. (2023). "The efficacy of combined ultrasound and electric field stimulation therapy in the treatment of venous leg ulcers." Scars, Burns & Healing 9: 20595131231174225.
17. Carter, M. J., et al. (2023). "Chronic wound prevalence and the associated cost of treatment in Medicare beneficiaries: changes between 2014 and 2019." Journal of Medical Economics 26(1): 894-901.
18. Carter, M. J., et al. (2023). "Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis." Advances in Wound Care 12(4): 177-186.
19. Herruzo, R., et al. (2023). "Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers." Wound Repair and Regeneration 31(3): 401-409.
20. Holubová, A., et al. (2023). "The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study." Antibiotics 12(9): 1364.
21. Li, S., et al. (2023). "The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of Personalized Medicine 13(3): 430.
22. Rayate, A. S., et al. (2023). "Current scenario of traditional medicines in management of diabetic foot ulcers: A review." World Journal of Diabetes 14(1): 1.
23. Saboia-Dantas, C. J., et al. (2023). "Progressive Platelet Rich Fibrin tissue regeneration matrix: Description of a novel, low cost and effective method for the treatment of chronic diabetic ulcers—Pilot study." Plos one 18(5): e0284701.
24. Shapira, E., et al. (2023). "The efficacy of combined ultrasound and electric field stimulation therapy in the treatment of venous leg ulcers." Scars, Burns & Healing 9: 20595131231174225.
25. Carter, M. J., et al. (2023). "Chronic wound prevalence and the associated cost of treatment in Medicare beneficiaries: changes between 2014 and 2019." Journal of Medical Economics 26(1): 894-901.
26. Carter, M. J., et al. (2023). "Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis." Advances in Wound Care 12(4): 177-186.
27. Herruzo, R., et al. (2023). "Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers." Wound Repair and Regeneration 31(3): 401-409.
28. Holubová, A., et al. (2023). "The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers—A Prospective Case-Control Study." Antibiotics 12(9): 1364.
29. Li, S., et al. (2023). "The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of Personalized Medicine 13(3): 430.
30. Rayate, A. S., et al. (2023). "Current scenario of traditional medicines in management of diabetic foot ulcers: A review." World Journal of Diabetes 14(1): 1.
31. Saboia-Dantas, C. J., et al. (2023). "Progressive Platelet Rich Fibrin tissue regeneration matrix: Description of a novel, low cost and effective method for the treatment of chronic diabetic ulcers—Pilot study." Plos one 18(5): e0284701.
32. Shapira, E., et al. (2023). "The efficacy of combined ultrasound and electric field stimulation therapy in the treatment of venous leg ulcers." Scars, Burns & Healing 9: 20595131231174225.