HISTOLOGICAL FINDINGS ON FORMULATION AND STABILITY OF AA-21 IN ALOPECIA ON CHEMOTHERAPY INDUCED ALOPECIA MODEL OF RAT.

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Shumaila Shaikh
Sadaf Ibrahim
Mirza Tasawer Baig
Aneela Atta Ur Rahman

Keywords

Animal Model, Chemotherapy, Alopecia

Abstract

Introduction:  Hair  is  the  human  body’s  major  esthetic display part,  especially  in  cultural  and  social  interactions. Hair serves many vital functions which includes defense from contaminants and sweat-gland dispersion substances e.g. pheromones. Alopecia is a common term for loss of hair, the hair matrix comprised (inside and outside) medulla, cortex and hair cuticle. The inner root sheath composed of the cuticle of the inner root sheath, the sheet of Huxley and the sheet of Henley (inside to out). The occurrence of hair loss is reported to increase gradually with increasing age in each of these males and females in populous-based surveys of White people aged 20-70 aged.


Methodology: This pre-clinical animal study was performed on wistar albino rats at animal house of faculty of pharmacy Ziauddin University Karachi. The duration of this study was eight to ten months. The successful induction of Alopecia was done, the animals were divided into three groups with six animals per group and all the CIA wistar rats were tested for effects of AA-21 on Alopecia as topical formulations and H&E was performed and our


Results were satisfactory.

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References

1. Al-joda, A. M., & Zalzala, M. H. (2019). Inhibition of NF-kB Pathway by Gggulsterone in the Protective Effects of Cyclophosphamide-Induced Renal Toxicity. Iraqi Journal of Pharmaceutical Sciences (P-ISSN: 1683-3597, E-ISSN: 2521-3512), 28(2), 180-185.
2. Ellis, J. A., & Harrap, S. B. (2001). The genetics of androgenetic alopecia. Clinics in dermatology, 19(2), 149-154.
3. Gordon, K. A., & Tosti, A. (2011). Alopecia: evaluation and treatment. Clinical, cosmetic and investigational dermatology, 4, 101.
4. Hassan, R. H., & Jwaid, A. H. (2021). The Use of Pentoxifylline Topical in the Treatment of Alopecia in Rats. Indian Journal of Forensic Medicine & Toxicology, 15(2), 3241.
5. Kyriakis, K. P., Paltatzidou, K., Kosma, E., Sofouri, E., Tadros, A., & Rachioti, E. (2008). Alopecia areata prevalence by gender and age. Journal of the European Academy of Dermatology and Venereology: JEADV, 23(5), 572-573.
6. Liu, Y., Lyle, S., Yang, Z., & Cotsarelis, G. (2003). Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. Journal of Investigative Dermatology, 121(5), 963-968.
7. Madani, S., & Shapiro, J. (2000). Alopecia areata update. Journal of the American Academy of Dermatology, 42(4), 549-566. 16. Kranseler, J. S., & Sidbury, R. (2017). Alopecia areata: Update on management. Indian Journal of Paediatric Dermatology, 18(4), 261.(new refrence)
8. Ohtani, T., Nakamura, T., Toda, K. I., & Furukawa, F. (2006). Cyclophosphamide enhances TNF-α-induced apoptotic cell death in murine vascular endothelial cell. FEBS letters, 580(6), 1597-1600.
9. Ramos, P. M., & Miot, H. A. (2015). Female pattern hair loss: a clinical and pathophysiological review. Anais brasileiros de dermatologia, 90, 529-543.
10. Strazzulla, L. C., Wang, E. H. C., Avila, L., Sicco, K. L., Brinster, N., Christiano, A. M., & Shapiro, J. (2018). Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis. Journal of the American Academy of Dermatology, 78(1), 1-12.
11. Tilg, H. E. R. B. E. R. T., Eibl, B. R. I. G. I. T. T. E., Pichl, M. A. R. I. O. N., Gächter, A. N. N. E., Herold, M. A. N. F. R. E. D., Brankova, J. U. L. I. A. N. A., ... & Niederwieser, D. I. E. T. G. E. R. (1993). Immune response modulation by pentoxifylline in vitro. Transplantation, 56(1), 196-201.
12. Zarbo, A., Belum, V. R., Sibaud, V., Oudard, S., Postow, M. A., Hsieh, J. J., ... & Lacouture, M. E. (2017). Immune‐related alopecia (areata and universalis) in cancer patients receiving immune checkpoint inhibitors. British Journal of Dermatology, 176(6), 1649-1652.

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