Main Article Content

Ayush Kartikey
Anshita Gupta
Dr. Vivek Gupta


Dapagliflozin and Vildagliptin, Diabetes, Bi layer tablet, Fast dissolving, Gastroretentive


Diabetes is a chronic illness that results from insufficient insulin production by the pancreas or from inefficient insulin usage by the body. Combination therapy employing two antidiabetic medications effectively manages these numerous problems. The creation of the bi-layer tablet, which combines several qualities with a controlled release formulation, is a new chapter in the successful delivery of medication. The goal of the current study was to create bi-layer tablets containing Dapagliflozin fast dissolving and Vildagliptin gastro retentive tablets. At first, about nine formulations of Dapagliflozin instant release tablets were prepared Result of pre compression parameter for these nine formulations were found to be within limits. The result of post compression parameter revealed that maximum drug content in formulation IF7 which is 99.45±0.26. Further about eight formulations of Vildagliptin tablets were prepared. The post compression properties of Vildagliptin tablets revealed that maximum drug content of 99.45±0.14 in F7 formulation. The post compression parameter of bilayer tablet was then performed. The hardness & friability was estimated to be 6.8 kg/cm2 & 0.658 % respectively while the thickness was found to be 5.12mm.  The drug content in bilayer tablet was observed to be 99.18% for Dapagliflozin and 99.45% for Vildagliptin. According to dissolution rate studies of bilayer tablets it was observed that within 1.5 hour the % drug release with respect to Dapagliflozin was 98.65% while for Vildagliptin it was 98.14% in 12 hours. The current investigation found that bilayer tablets containing Dapagliflozin and Vildagliptin may be a preferable option than standard dosage forms

Abstract 216 | pdf Downloads 99


1. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress—A concise review. Saudi pharmaceutical journal. 2016 Sep 1;24(5):547-53.
2. Padhi S, Nayak AK, Behera A. Type II diabetes mellitus: a review on recent drug based therapeutics. Biomedicine & Pharmacotherapy. 2020 Nov 1;131:110708.
3. Bailey CJ, Day C. Antidiabetic drugs. British journal of cardiology. 2003 Mar;10:128-36.
4. Gimenes HT, Zanetti ML, Haas VJ. Factors related to patient adherence to antidiabetic drug therapy. Revista Latino-Americana de Enfermagem. 2009;17:46-51.
5. Prabhakar PK, Kumar A, Doble M. Combination therapy: a new strategy to manage diabetes and its complications. Phytomedicine. 2014 Jan 15;21(2):123-30.
6. Yki-Järvinen H. Combination therapies with insulin in type 2 diabetes. Diabetes care. 2001 Apr 1;24(4):758-67.
7. Panchal HA, Tiwari AK. A novel approach of bilayer tablet technology: a review. International Research journal of pharmacy. 2012 May;3(5):44-9.
8. Rameshwar V, Kishor D, Tushar G. Bi-layer tablets for various drugs: A review. Scholars Academic Journal of Pharmacy. 2014;3(3):271-9.
9. Deshpande RD, Gowda DV, Mahammed N, Maramwar DN. Bi-layer tablets-An emerging trend: a review. International journal of pharmaceutical sciences and research. 2011 Oct 1;2(10):2534.
10. Plosker GL. Dapagliflozin: a review of its use in patients with type 2 diabetes. Drugs. 2014 Dec;74:2191-209.
11. Dhillon S. Dapagliflozin: a review in type 2 diabetes. Drugs. 2019 Jul 1;79(10):1135-46.
12. Keating GM. Vildagliptin: a review of its use in type 2 diabetes mellitus. Drugs. 2010 Nov;70:2089-112.
13. Halimi S, Raccah D, Schweizer A, Dejager S. Role of vildagliptin in managing type 2 diabetes mellitus in the elderly. Current medical research and opinion. 2010 Jul 1;26(7):1647-56.
14. Suresh S, Pandit V, Joshi HP. Preparation and evaluation of mouth dissolving tablets of salbutamol sulphate. Indian journal of pharmaceutical sciences. 2007 May 1;69(3).
15. Rane DR, Gulve HN, Patil VV, Thakare VM, Patil VR. Formulation and evaluation of fast dissolving tablet of albendazole. International Current Pharmaceutical Journal. 2012 Sep 5;1(10):311-6.
16. Hardikar S, Bhosale A. Formulation and evaluation of gastro retentive tablets of clarithromycin prepared by using novel polymer blend. Bulletin of Faculty of Pharmacy, Cairo University. 2018 Dec 1;56(2):147-57.
17. Bomma R, Naidu RA, Yamsani MR, Veerabrahma K. Development and evaluation of gastroretentive norfloxacin floating tablets. Acta pharmaceutica. 2009 Jun 1;59(2):211-21.
18. Raza A, Hayat U, Wang HJ, Wang JY. Preparation and evaluation of captopril loaded gastro-retentive zein based porous floating tablets. International Journal of Pharmaceutics. 2020 Apr 15;579:119185.
19. Payghan SA, Disuza JI. Formulation, evaluation and development of bilayer tablet. Int. J. Pharmaceut. Res. Dev.. 2011;3:80-7.
20. Maddiboyina B, Hanumanaik M, Nakkala RK, Jhawat V, Rawat P, Alam A, Foudah AI, Alrobaian MM, Shukla R, Singh S, Kesharwani P. Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension. Heliyon. 2020 Nov 1;6(11).
21. Bijank G, Rabindra D, Soumyadeep G, Manas C, Amitava B. Formulation development studies of bilayer tablet glipizide: A novel and evolutionary approach in the treatment of diabetes. Asian J. Pharm. Clin. Res. 2013