EFFICACY OF SOFOSBUVIR/DACLATASVIR IN CIRRHOTIC AND NON-CIRRHOTIC PATIENTS WITH HCV GENOTYPE 4 INFECTION AT A SPECIALIST HOSPITAL.

Main Article Content

Dr. Shivananda Murgod E
Dr Sumaira Ahmed
Dr Ahmed Shoqueer
Dr. Majed Alharbi
Dr Nawaf Almutairi
Dr. Abdullah Alqifari

Keywords

Hepatitis, Cirrhosis, Daclatasvir, Sofosbuvir, Sustained virological response

Abstract

Introduction: Untreated Hepatitis C virus infection can lead to cirrhosis, hepatocellular cancer and even death and increases liver disease related morbidity and mortality worldwide. Treatment with Direct Acting Antivirals offer cure over 90% with fewer side effects. Daclatasvir (DCV) and Sofosbuvir (SOF) combination in HCV GT4 infection has imparted higher rates of SVR after treatment with great tolerability.


This study assesses the effectiveness of this regimen in eradication of the HCV GT4 infection in treatment-naïve patients.


Methods: A retrospective study, conducted in our center between June 2017 and December 2020. Treatment protocol was given in treatment-naive HCV GT4 infected cirrhotics and noncirrhotics participants who were later followed for a total of 24 weeks for safety and efficacy of SOF-DCV. Data was analyzed using SPSS, and figures created using MS-Excel.


Results: We analyzed data of 124 participants with HCV GT 4 infection. Mean age was (54.04 +/- 16.39) Treatment regimen was given to 39 cirrhotic (F4) and  85 non-cirrhotic(F0-F3). SVR was seen in 98% of participants with tolerable side effects and improved MELD scores as fall in percentage seen from 46.1% to 40.5% in participant’s with MELD>10.


Discussion: This retrospective study confirms that SOF-DCV is safe and effective treatment regimen in HCV GT4 patients. The findings are consistent with findings of multiple clinical trials. Our study was conducted exclusively on HCV genotype 4 with good number of participants. Treatment completion was followed by high SVR12 rated and improvement in prognostic markers of liver disease in participants with compensated cirrhosis.


Conclusion: SOF-DCV combination showed efficacy in achieving the SVR12 in Child-Pugh B cirrhotic and noncirrhotic population with a favorable safety profile.

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