PREVALENCE AND GEOGRAPHICAL BURDEN OF SCRUB TYPHUS DISEASE IN CENTRAL INDIA: A CROSS-SECTIONAL STUDY

Main Article Content

Santosh kumar
Sohan lal
Suraj Yadav
Ankur Pandey
Sapna Kushwah

Keywords

Scrub typhus disease, MP, Orientia tsutsugamushi

Abstract

 Background and objectives: Scrub typhus, a vector – borne zoonotic disease is produced through
bacteria Orientia tsutsugamushi, a potentially lethal re-emerging infectious disease in India. Scrub
typhus, produce severe multiorgan failure and has a circumstance fatality rate of up to 70% if not
treated properly. The geographical burden of the disease remains unclear in this region. Our goal is to
present the geographical burden and prevalence of scrub typhus in Madhya Pradesh Central India with
the management of scrub typhus in both long standing endemic regions and newly identified infection
foci and to identify the integration with the effectiveness of various available serological diagnostic
methods, ELISA, rapid immunochromatography test, weil Felix test, clinical and medical laboratory
results to support the diagnosis of scrub typhus patients.
Methodology: A total 524 patients undiagnosed acute undifferentiated febrile illness (AUFI) >5 days
with the age of 3 yrs to 75 yrs included in the study with suspected scrub typhus. Various serological
diagnostic methods rapid immunochromatography test, ELISA, Weil Felix test applied for the
detection of scrub typhus cases with the clinical features, medical laboratory parameter and final result
analyzed.
Principal findings: Scrub typhus epidemiology varies due to Climate conditions, etiological agents
and arthropod vectors involved in transmission. Scrub typhus is a disease with a unique epidemiology
in MP and its regional distribution were found to be varied in this study, with the highest percentage
of cases recorded (66.6%) in Mandsaur (22.2%)in Ratlam and (11.1%) in Betul districts of Madhya
Pradesh, Central India.Theseroprevealencewas increases during the month of August (48.1%),
September (40.7%) and October (11.1%). The study shows that 5.1% (n=524) positive cases of scrub
typhus through the various serological diagnostic methods.
Conclusion: Our study revealed an increasing trend of scrub typhus in MP, Central India, Morbidity
and Mortality will be reduced if diagnosed early through ICT, ELISA and treated appropriately. The
general population's awareness of the patterns of disease transmission and the implementation of
preventive measures like insect repellents and protective clothing are crucial in decreasing the
prevalence of disease.

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