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Hemakshi Chaudhari
Chandrakant Gawli
Anoop Kumar
Dr. Chandragouda R. Patil.


Neonatal Jaundice, Oxidative Stress, Malondialdehyde, Total Antioxidant Capacity, Total Oxidative Stress, Cytokines, TNF-α, IL-6


Purpose: Phototherapy is used in the treatment of neonatal hyperbilirubinemia. There are contravening reports on its its adverse effect. This meta-analysis was conducted to substantiate the impact of phototherapy on the parameters indicating oxidative stress and pro-inflammatory cytokines.

Methods: The relevant clinical studies were searched on PubMed, Google Scholar, Stanford University High-Wire Press, Clinical trial registry, and on Semantic Scholar published up to 30th July 2022. Newcastle-Ottawa Scale was used to assess the study qualities. The overall estimate was calculated in terms of odds ratio with 95% confidence interval using random effect model. The sensitivity and subgroup analysis were carried out along with the qualitative assessment of the publication bias. All the analysis was carried out using RevMan 5.

Results: Total 1735 participants from 31 pertinent studies were used for the quantitative analysis. The pooled estimates of the phototherapy-exposed group were compared with the control group. Our analysis revealed that phototherapy used in treating neonatal jaundice induced significant oxidative stress and increased the levels of inflammatory cytokines. Overall estimate measure i.e., mean difference was found to be significant [1.39 (0.79 1.99)] for MDA (nmol per ml), [-0.87 (-1.35 -0.39)] for MDA (nmol per litre) [-0.25 (-0.34 -0.15)] for TAC, [-81.68 (-105.50 -57.85)] for TNF-α, and non-significant for TOS and IL-6 i.e [1.36(-2.67 5.39)] and [1.96 (-0.89 4.81)] respectively                                                                                               

Conclusion: Therapeutic exposure to phototherapy in treating neonatal jaundice induces a rise in oxidative stress and inflammatory cytokine levels. The short and long-term clinical outcomes may have clinical significance.


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