SLEEP QUALITY IN COVID 19 PATIENTS AND ITS ASSOCIATION WITH SEVERITY OF COVID

Abstract

Introduction: Bad sleep quality is associated with deregulated immune response; therefore an individual is prone to develop various viral infections.

 Aim: of the study was to assess quality of sleep in COVID 19 patients and its association with severity of disease.

Methods: this was a prospective questionnaire based study. One hundred and twenty three subjects with microbiologically confirmed COVID 19 were administered Pittsburgh Sleep Quality Index (PSQI) questionnaire. Disease severity was assessed with HRCT thorax. Demographic data and co morbidities were noted. Correlation between quality of sleep parameters and disease severity determined.

Results: Analysed data of 123 subjects. Mean age was 51.69 ± 13.17 years. Male: Female ratio was 2.1:1. Co-morbidities were found in 41%; among which Diabetes mellitus, Hypertension, combined DM and HTN, CAD, Hypothyroidism and Airway diseases were 39%, 37%, 22%, 23%, 14% and 10% respectively. Out of 118 patients with HRCT, based on CT Severity Index, subjects with mild, moderate and severe disease were 46% (54), 37% (44) and 17% (20) respectively. Based on global PSQI, 51% (62) had bad quality of sleep. Good or bad quality of sleep doesn’t have association with age and gender. Bad subjective sleep quality was reported in 21% subjects and it’s not related to disease severity grades. Insomnia (Sleep latency of >30 min) reported in 22% of the subjects and it’s correlated with severe COVID disease (P value: 0.095; <0.10).

Conclusion: In this study we observed severe COVID is associated with bad quality and reduced sleep duration. Global PSQI can be used as a screening instrument to predict severity of COVID 19.Validation of global PSQI as a screening instrument for development of severe COVID 19 is recommended.