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Sheetal Lodhi
Vinit Kumar
Amit Pal
Abhsihek Kumar
Rahul Vishwakarma
Bobby Rawat
Vipin Kesharwani
Pranki Shukla
Aman Agrahari
Akash Patel


Cytochrome P450, Antioxidant, Acaricidal, Nematocidal


Eucalyptus globulus, a well-known species, has a wealth of therapeutic potential. The Eucalyptus globulus species, sometimes known as blue gum, thrives well in the Nilgiris, Annamalai, Palani, and Shimla hills. It has a high concentration of phytochemical elements like as flavonoids, alkaloids, tannin, and propanoid, which are found in the plant's leaves, steam, and root. Eucalyptus is extensively planted for pulp, plywood, solid wood production but its leaf aromatic oil has astounding wide spread biological activities including antimicrobial, antiseptic, antioxidant, chemotherapy agent, anticancer Cytochrome p450, Hepatoprotective effect, respiratory and gastrointestinal disorders treatment, wound healing, and insecticidal/insect repellent, herbicidal, acaricidal, nematocidal, and perfumes, soap making and grease remover. In this study, we attempted to compile the biological components of leaf essential oil, leaf oil as a natural medicine, and the pharmacological and toxicological properties of several Eucalyptus species from around the world. The elements of Eucalyptus will disclose secrets beyond the traditional benefits for treating a wide range of diseases.

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1. Vecchio, M. G., Loganes, C., & Minto, C. (2016). Beneficial and healthy properties of Eucalyptus plants: A great potential use. The Open Agriculture Journal, 10, 52–57
2. Kantvilas, G. (1996). The discovery of tasmanian eucalypts: An historical sketch. Tasmanian Herbarium, 8
3. Sebei, K., Sakouhi, F., Herchi, W., Khouja, M. L., &Boukhchina, S. (2015). Chemical composition and antibacterial activities of seven Eucalyptus species essential oils leaves. Biological Research, 48, 1–5.
4. Sharifi-Rad, J., Salehi, B., Varoni, E. M., Sharopov, F., Yousaf, Z., Ayatollahi, S. A., et al. (2017). Plants of the melaleuca genus as antimicrobial agents: From farm to pharmacy. Phytotherapy Research. https://doi.org/10.1002/ptr.5880.
5. Mohamed, S. B., Amine, F. M., Kameli, A., Walid, K., Boukhatem, M. N., & Saidi, F. (2015). Quality assessment of the essential oil from Eucalyptus globulus Labill of blida (Algeria) origin international Letters of chemistry. Physics and Astronomy, 36, 303–315.
6. Barra, A., Coroneo, V., Dessi, S., Cabras, P., &Angioni, A. (2010). Chemical variability, antifungal and antioxidant activity of Eucalyptus camaldulensis essential oil from Sardinia. Natural Product Communications, 5, 329–335
7. Ben Jemâa, J. M., Haouel, S., Bouaziz, M., & Khouja, M. L. (2012). Seasonal variations in chemical composition and fumigant activity of five Eucalyptus essential oils against three moth pests of stored dates in Tunisia. Journal of Stored Products Research, 48, 61–67
8. Abubakar, E. M. M. (2010). Antibacterial potential of crude leaf extracts of Eucalyptus camaldulensis against some pathogenic bacteria. African Journal of Plant Science, 4, 202–209.
9. Gómez-Estrada, H., Díaz-Castillo, F., Franco-Ospina, L., Mercado-Camargo, J., GuzmánLedezma, J., Medina, J. D., et al. (2011). Folk medicine in the northern coast of Colombia: An overview. Journal of Ethnobiology and Ethnomedicine, 7, 1–10
10. Nordqvist, J. (2017). Eucalyptus: What are the health benefits? Medical news today: MediLexicon, intlhttps://www.medicalnewstoday.com/articles/266580.php.
11. Van Wyk, B. E., & Wink, M. (2017). Medicinal plants of the world. Pretoria: Briza Publications.
12. Qabaha, K., Abu Ras, S., Abbadi, J., & Al-Rimawi, F. (2016). Anti-inflammatory activity of Eucalyptus spp. and Pistascia lentiscus leaf extracts. African Journal of Traditional, Complementary, and Alternative Medicines, 13, 1–6.
13. Salari, M. H., Amine, G., Shirazi, M. H., Hafezi, R., &Mohammadypour, M. (2006). Antibacterial effects of Eucalyptus globulus leaf extract on pathogenic bacteria isolated from specimens of patients with respiratory tract disorders. Clinical Microbiology and Infections, 12, 194–196
14. Kluthe, B. M. G., & Chen, D. K. (2017). Eucalyptus sp. at the intersection of environment and culture in Kenya. Ethnobiology Letters, 8, 15–22.
15. Knezevic, P., Aleksic, V., Simin, N., Svircev, E., Petrovic, A., & Mimica-Dukic, N. (2016).
16. Pennacchio, M., Jefferson, L., & Havens, K. (2010). Uses and abuses of plant-derived smoke: Its ethnobotany as hallucinogen, perfume, incense and medicine. United Kingdom: Oxford University Press Inc.
17. Williams, C. (2011). Medicinal plants in Australia. Vol. 2Australia: Rosenberg Publishing Pty Ltd.
18. Adamu, U., & Yushau, M. (2018). In vitro antibacterial activity and toxicity study of Eucalyptus camaldulensis leaf extract against clinical isolates of Salmonella spp. Dutse Journal of Pure and Applied Sciences, 4, 213–220
19. Lewington, A. (2003). Plants for people. Random House.
20. Elaissi, A., Salah, K. H., Mabrouk, S., Larbi, K. M., Chemli, R., &Harzallah-Skhiri, F. (2011). Antibacterial activity and chemical composition of 20 Eucalyptus species' essential oils. Food Chemistry, 129, 1427–1434
21. Bouzabata, A., Bighelli, A., Abed, L., Casanova, J., & Tomi, F. (2014). Composition and chemical variability of Eucalyptus bosistoana essential oil from Algerian Sahara. Natural Product Communications, 9, 701–702
22. Barbosa, L. C. A., Filomeno, C. A., & Teixeira, R. R. (2016). Chemical variability and biological activities of Eucalyptus spp. essential oils. Molecules, 21, 1671.
23. Abd El-Mageed, A. A., Osman, A. K., Tawfik, A. Q., & Mohammed, H. A. (2011). Chemical composition of the essential oils of four Eucalyptus species (Myrtaceae) from Egypt. Research Journal of Phytochemistry, 5, 115–122
24. Marzoug, H. N. B., Bouajila, J., Ennajar, M., Lebrihi, A., Mathieu, F., Couderc, F., et al. (2010). Eucalyptus gracilis, oleosa, salubris, and salmonophloia essential oils: Their chemical composition and antioxidant and antimicrobial activities. Journal of Medicinal
25. Maciel, M. V., Morais, S. M., Bevilaqua, C. M. L., Silva, R. A., Barros, R. S., Sousa, R. N., et al. (2010). Chemical composition of Eucalyptus spp. essential oils and their insecticidal effects on Lutzomyia longipalpis. V
26. Marzoug, H. N. B., Romdhane, M., Lebrihi, A., Mathieu, F., Couderc, F., Abderraba, M., et al. (2011). Eucalyptus oleosaessential oils: Chemical composition and antimicrobial and antioxidant activities of the oils from different plant parts (stems, leaves, flowers and fruits). Molecules, 16, 1695–1709.
27. Bachir, R. G., & Benali, M. (2012). Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pac J Trop Biomed, 2, 739–742.
28. Ghalem, B. R., & Mohamed, B. (2008). Antibacterial activity of leaf essential oils of Eucalyptus globulus and Eucalyptus camaldulensis. African Journal of Pharmacy and Pharmacology, 2, 211–215.
29. Gakuubi, M. M., Maina, A. W., &Wagacha, J. M. (2017). Antifungal activity of essential oil of Eucalyptus camaldulensis Dehnh. against selected Fusarium spp. International Journal of Microbiology, 1–7 2017.
30. Vimalanathan, S., & Hudson, J. (2014). Anti-influenza virus activity of essential oils and vapors. American Journal of Essential Oils and Natural Products, 2, 47–53.
31. Döll-Boscardin, P. M., Sartoratto, A., De Noronha Sales Maia, B. H. L., Padilha De Paula, J., Nakashima, T., Farago, P. V., et al. (2012). In vitro cytotoxic potential of essential oils of Eucalyptus benthamii and its related terpenes on tumor cell lines. Evidence-based Complementary and Alternative Medicine. 2012 https://doi.org/10.1155/2012/ 342652.
32. Mirzaalizadeh, B., Sharif, M., Daryani, A., Ebrahimzadeh, M. A.,., Zargari, M., Sarvi, S., et al. (2018). Effects of Aloe vera and Eucalyptus methanolic extracts on experimental toxoplasmosis in vitro and in vivo. Experimental Parasitology, 192, 6–11.
33. Ahlem, S., Khaled, H., Wafa, M., Sofiane, B., Mohamed, D., Jean-Claude, M., et al. (2009). Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats. Chemico-Biological Interactions, 181, 71–76.
34. Takasaki, M., Konoshima, T., Etoh, H., Singh, I. P., Tokuda, H., & Nishino, H. (2000). Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis. Cancer Letters, 155, 61–65.
35. Silva, J., Abebe, W., Sousa, S. M., Duarte, V. G., Machado, M. I. L., & Matos, F. J. A. (2003). Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. Journal of Ethnopharmacology, 89, 277–283
36. Upreti, A., Byanju, B., Fuyal, M., Chhetri, A., Pandey, P., Ranjitkar, R., et al. (2018). Evaluation of a-amylase, lipase inhibition and in-vivo pharmacological activities of Eucalyptus camaladulensisDehnh leaf extract. Journal of Traditional and Complementary Medicine, 1–7
37. Tiwari, A., Singh, P., Jaitley, P., Sharma, S., Prakash, A., Mandil, R., et al. (2018). Eucalyptus robusta leaves methanolic extract suppresses inflammatory mediators by specifically targeting TLR4/TLR9, MPO, COX2, iNOS and inflammatory cytokines in experimentally-induced endometritis in rats. Journal of Ethnopharmacology, 213, 149–158.
38. Park, B., Hwang, E., Seo, S. A., Cho, J. G., Yang, J. E., & Yi, T. H. (2018). Eucalyptus globulus extract protects against UVB-induced photoaging by enhancing collagen synthesis via regulation of TGF-β/Smad signals and attenuation of AP-1. Archives of Biochemistry and Biophysics, 637, 31–39.