FORMULATION AND EVALUATION OF CHITOSAN MICROSPHERES OF COMBINED DRUG (ISONIAZID AND PYRIDOXINE) RELEASE PROFILE BY IONOTROPIC GELATION METHOD.

Main Article Content

Alka Maral
Pooja Gupta
Prerna Gupta
Alok Semwal

Keywords

Microspheres, Gluteraldehyde, tripolyphosphate (TPP), formaldehyde (FA) Neuropathy

Abstract

Tuberculosis is an infectious disease that mainly affects the lungs. For the treatment of tuberculosis conventional drug delivery system fails to achieve efficient drug delivery at the target site. Now a days Chitosan microspheres become a topic of great interest as a novel drug delivery system. Chitosan microspheres for improving  therapeutic action of drug increasing prolongs action, lowering dose frequency of dosage form and to improve patient complies. The aim of this combined study was to overcome the side effect of antitubercular drug (Isoniazid) which is neuropathy and influence of the molar mass and deacetylation degree of chitosan microspheres at the different concentration of three different cross-linking agents viz, tripolyphosphate (TPP), formaldehyde (FA) and Gluteraldehyde (GA) has been prepare by Ionotropic gelation method.The influence of these cross- linking agent on the properties of chitosan microsphers was extensively investigated. The the partical size and encapsulation efficiencies of thus preparation chitosan microspheres ranged mainly between


Areas covered This research article Isoniazid/Pyridoxin combination therapy for the treatment of tuberculosis. The reduction of side effect of Isoniazid (neuropathy) and patients compliance of Isoniazid/pyridoxine in tubercular patients are discussed based on the available literature.


Expert opinion: It was found that Isoniazid/pyridoxine combination therapy for the treatment of tuberculosis combination therapy could significantly improve bioequivalence studies. It also reduces side effect of isoniazid nuropathy.

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