Main Article Content

Sachin Gulia
Vipin kumar
Megha Thakur
Dr Ashwani Kumar


Epileptogenesis, Epilepsy, Neurotransmitters, Pathophysiology, Signaling


There are several neurological disorders that can cause recurrent seizures. Epilepsy is one of them, and is characterized by a persistent predisposition to seizures caused by abnormal neuronal activity in the brain. The relative imbalance between excitatory and inhibitory neurotransmitters may result in epileptic seizures. Pathogenesis of epilepsy can be influenced by changes in the expression of receptors and ion channels regulated by neurotransmitters. A neurotransmitter metabolism error affects the synthesis, breakdown, transport or the cofactors of neurotransmitters. The impairment of neuronal receptors, intracellular signaling, vesicle release, or other synaptic abnormalities can also cause neurotransmitter dysfunction. The main clinical hallmark of some diseases is epilepsy. The purpose of this comprehensive review is to describe the epileptogenic mechanisms as well as the implications arising from mutations in neurotransmitter-mediated receptors and ion channels in epilepsy.

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