DETERMINATION OF CHEMICAL COMPOSITION AND THERAPEUTIC POTENTIAL OF CHICORY (CHICHORIUM INTYBUS) LEAVES POWDER IN MANAGEMENT OF HYPERLIPIDEMIA IN HUMAN SUBJECTS: A RANDOMIZED CONTROL TRIAL
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Keywords
hypolipidemic effect, Chichorium intybus,, lipid profile, phytochemical analysis
Abstract
Introduction: Hyperlipidemia is characterized as elevated lipid profile parameters. These parameters include cholesterol, triglycerides, low- and high-density lipoprotein this research was done to find out how chicory (Chichorium intybus) leaves powder affected hyperlipidemia.
Objectives: This study's goal was to analyses the chicory leaves powder's chemical make-up along with phytochemical contents.
Material and methods: Three groups were taken for the study with the name of control and treatment groups. Each group contain the equal no of hyperlipidemic patients on the basis of their inclusion and exclusion criteria. Treatment groups I and II received encapsulated doses of 20 mg and 40 mg of chicory leaves powder while control group were not taking anything. Biochemical profiles with special reference to lipid profile values of studied subjects were assessed and compared at 0 and 8 weeks. In IBM SPSS Statistics 20, ANOVA was used to assess each result.
Results: Proximate tests revealed that chicory leaves powder had 6.50.08 protein, 30.191.02 fiber, 5.010.23 ash, and 8.090.31 moisture, whereas nitrogen free extract comprised 44.311.17. Calcium and manganese were found to be the most abundant minerals in chicory leaf powder, according to mineral analysis. Chicory leaf powder contained 11.9 and 9.01 mg/g of total phenolic and total flavonoids compounds (TCF & TFC), respectively.
Conclusion: Phytochemicals and proximate analysis of chicory leaves confirmed that its use can cause a significant reduction in lipid profile indices triglycerides, cholesterol, and low-density lipoproteins with an increase in high density lipoproteins. At p0.05, all results were considered significant.
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Dr. Sajeela Akram
Department of Human Nutrition and Dietetics, University of Chakwal. Pakistan
Dr. Saira Zafar
Deaprtment of Public Health, Health Services Academy. Islamabad. Pakistan.
Dr. Samina Naeem Khalid
Department of Public Health, Health Services Academy. Islamabad. Pakistan
Dr. Umar Farooq
Department of Nutrition and Dietetics, National University of Medical Sciences. Rawalpindi. Pakistan
Dr. Hassan Bin Usman Shah
The Kirby Institute, University of New South Whales, Sydney, NSW, Australia
Dr. Madiha Ghazanfar
Department of Diet and Nutritional Sciences, Ibadat International University, Islamabad, Pakistan,
Dr. Abdul Momin Rizwan Ahmad
Department of Nutrition and Dietetics, National University of Medical Sciences. Rawalpindi. Pakistan.
Dr. Juweria Abid
Department of Nutrition and Dietetics, National University of Medical Sciences. Rawalpindi. Pakistan.