THE STUDY OF RELATIONSHIP BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM AND GESTATIONAL DIABETES MELLITUS AND ITS PREGNANCY OUTCOMES
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Keywords
Single nucleotide polymorphism, Gestational diabetes mellitus, Pregnancy outcomes, cardio metabolic risk factors
Abstract
GDM is a major cause for perinatal morbidity and mortality complications such as shoulder dystocia, macrosomia, hyperbilirubinemia, hypoglycemia, long term type 2 diabetes mellitus, maternal death, Pre-eclampsia. Hence it is one of the most important global health problems to be addressed. Pregnancy is a physiological state which can significantly alter both the maternal and fetal metabolic processes bringing in an insulin resistance (IR) like state. During Pregnancy insulin resistance may develop which can lead to increased maternal adiposity, impaired beta cell.
AIM: This study is designed to find the association of SNPs of genes related to Insulinresistance (KCNQ1, IGFBP2) with the biochemical markers of GDM and to correlate thisassociationwiththematernalandfetaloutcomesinGestationaldiabetesmellitus.
MATERIAL AND METHODS: The molecular and biochemical markers was investigated in 419 pregnant women (Pregnant women with GDM (group 1-case, n=210), Pregnant women without GDM (group 2-control, n=209). A total of 5ml of venous blood was collected from the pregnant women with GDM. REPORTS: There was association between KCNQ1 gene and IGF2BP2 gene polymorphism in Gestational diabetes mellitus. CONCLUSION: which could identify at-risk patients in early stages and designing new therapeutics which will thus help in diagnostics, treatment and eventually prevention of this disease further studies are needed to confirm these findings in different functional genes and their associated microRNA and protein expression in pregnant women with GDM.
References
2. Vani K. Alterations in lipid profile in gestational diabetes mellitus (GDM) and type 2 DM women during pregnancy. Int J Med Res Rev [Internet]. 2015 Sep 30 [cited 2017 May 26];3(08). Available from: http://medresearch.in/index.php/IJMRR/article/view/351
3. Gopalakrishnan V, Singh R, Pradeep Y, Kapoor D, Rani AK, Pradhan S, et al. Evaluation of the prevalence of gestational diabetes mellitus in North Indians using the International Association of Diabetes and Pregnancy Study groups (IADPSG) criteria. Journal of postgraduate medicine. 2015 Jul;61(3):155.
4. Kalra P, Kachhwaha CP, Singh HV. Prevalence of gestational diabetes mellitus and its outcome in western Rajasthan. Indian journal of endocrinology and metabolism. 2013 Jul;17(4):677.
5. Mitanchez D. Foetal and neonatal complications in gestational diabetes: perinatal mortality, congenital malformations, macrosomia, shoulder dystocia, birth injuries, neonatal complications. Diabetes & metabolism. 2010 Dec;36(6 Pt 2):617-27.
6. Kongnyuy EJ, Nana PN, Fomulu N, Wiysonge SC, Kouam L, Doh AS. Adverse Perinatal Outcomes of Adolescent Pregnancies in Cameroon. Matern Child Health J. 2008 Mar 1;12(2):149–54.
7. Sonagra AD, Biradar SM, Dattatreya K, DS JM. Normal pregnancy-a state of insulin resistance. Journal of clinical and diagnostic research: JCDR. 2014 Nov;8(11):CC01.
8. Al-Noaemi MC, Shalayel MH. Pathophysiology of gestational diabetes mellitus: the past, the present and the future. InGestational Diabetes 2011. InTech.
9. Moore DJ, Gregory JM, Kumah-Crystal YA, Simmons JH. Mitigating micro-and macro- vascular complications of diabetes beginning in adolescence. Vascular health and risk management. 2009;5:1015.
10. Yoon HJ, Cho YZ, Kim JY, Kim BJ, Park KY, Koh GP, et al. Correlations between glucagon stimulated C-peptide levels and microvascular complications in type 2 diabetes patients. Diabetes & metabolism journal. 2012 Oct 1;36(5):379-87.
11. Mudaliar S, Edelman SV. Insulin therapy in type 2 diabetes. Endocrinol Metab Clin North Am. 2001 Dec;30(4):935–82.
Hodson K, Robson S, Taylor R. Gestational diabetes: emerging concepts in pathophysiology. Obstetric medicine. 2010 Dec;3(4):128-32.
13. Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest. 2016 Jan 4;126(1):12.
14. Herath H, Herath R, Wickremasinghe R. Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women—A community based retrospective cohort study. PloS one. 2017 Jun 23;12(6):e0179647.
15. Rojas LB, Gomes MB. Metformin: an old but still the best treatment for type 2 diabetes. Diabetology & metabolic syndrome. 2013 Dec;5(1):6.
16. Hostalek U, Gwilt M, Hildemann S. Therapeutic use of metformin in prediabetes and diabetes prevention. Drugs. 2015 Jul 1;75(10):1071-94.
17. Feig DS, Zinman B, Wang X, Hux JE. Risk of development of diabetes mellitus after diagnosis of gestational diabetes. Canadian Medical Association Journal. 2008 Jul 29;179(3):229-34.
18. Franzago M, Fraticelli F, Nicolucci A, Celentano C, Liberati M, Stuppia L, et al. Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women. Journal of diabetes research. 2017; Jan 4;31(2):568-7.
19. Li Q, Tang TT, Jiang F, Zhang R, Chen M, Yin J, et al. Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes. Acta Pharmacologica Sinica. 2017 Jan;38(1):80.
20. Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A, Nilsson P, et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes. 2009 Jul 7.
21. Khadem N, Rahmani ME, Sanaei A, Afiat M. Association between preterm and low-birth weight with periodontal disease: a case-control study. Iranian journal of reproductive medicine. 2012 Nov;10(6):561.
22. Khadem N, Rahmani ME, Sanaei A, Afiat M. Association between preterm and low-birth weight with periodontal disease: a case-control study. Iranian journal of reproductive medicine. 2012 Nov;10(6):561.
23. Lukasova P, Vcelak J, Vankova M, Vejrazkova D, Andelova K, Bendlova B. Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations. Physiological research. 2008 Jan 1;57(1):S99.
24. Van Hoek M, Langendonk JG, de Rooij SR, Sijbrands EJ, Roseboom TJ. A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism. Diabetes. 2009 Feb 28.
25. Popova PV, Klyushina AA, Vasilyeva LB, Tkachuk AS, Bolotko YA, Gerasimov AS, et al. Effect of gene-lifestyle interaction on gestational diabetes risk. Oncotarget. 2017 Dec 19;8(67):112024
26. Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. The Journal of clinical investigation. 2006 Jul 3;116(7):1767-75.
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Dr. M. Lenin
Assistant Professor, Sri Lakshmi Narayana Institute of Medical science Puducherry
Dr. S. Selvakumar
Assistant professor, Department of Physiology, Dhanalakshmi Srinivasan Medical college and Hospital, Perambalur, Tamil Nadu,
Dr. A. Swathika
Assistant Professor, Sri Lakshmi Narayana Institute of Medical science Puducherry
Dr. Ramesh Ramasammy
Professor, JIPMER, Puducherry
Mohana Valli. V
Tutor, Sri Lakshmi Narayana Institute of Medical science Puducherry